Arizona Diamondbacks vs. Minnesota Twins Prediction and Picks - September 12, 2025
Arizona Diamondbacks vs. Minnesota Twins Prediction and Picks - September 12, 2025
The Diamondbacks are traveling to Target Field in Minneapolis, Minnesota for their series against the Twins; keep reading for our Diamondbacks versus Twins prediction. Arizona is fourth in the NL West with a record of 73-74. Minnesota is fourth in the AL Central with a record of 64-82. The Diamondbacks had a 1-2 record against the Twins in 2024. The first pitch is scheduled for 8:10 p.m. EDT. Don’t go down on strikes! Get our top MLB Betting Picks and increase your bankroll!
Diamondbacks Fall Short Of Playoffs Due To Pitching
The Diamondbacks are coming off a win on Wednesday versus the Giants with a final score of 5-3. Unfortunately, the Diamondbacks would still find a series loss against the Giants 1-2. This win, however, would break up a three-game losing streak as the Diamondbacks continue on their six-game road trip. Arizona is technically not out of the wild card race but it is unlikely they will make it as the Mets hold a tight grip on the final National League wild card spot with a winning percentage of .521 to the Diamondbacks’ .497.
Arizona looked great this season at the plate, ranking sixth overall in runs and 13th in batting average at .250. The key to their offense stems from their ability to get on base and bring home runners with their impressive hitting. The Diamondbacks had an on-base percentage of .323 (8th) and ranked third overall in slugging percentage at .434. Unfortunately, this was not enough to counter their poor pitching, which sat 23rd overall in ERA at 4.47 and 18th in home runs. Arizona will look to strengthen their pitching core and bullpen for next season to match the strength of their offense.
Right-handed pitcher Brandon Pfaadt will be starting for the Diamondbacks on Friday.
Brandon Pfaadt:
- has a 13-8 record with an ERA of 5.18 and 129 strikeouts in 29 appearances this season.
- has allowed 4 runs on 5 hits with 2 walks and 2 strikeouts in 6.1 innings versus the Twins in his career.
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Twins Unable To Find Consistency
The Twins picked up a loss on Wednesday versus the Angels with a final score of 4-3. This would lose them the series against the Angels 1-2 as they end a six-game road trip with a 2-4 record. Minnesota has no chance of making it to the playoffs and have been rotating in rookie players to get exposure for next season.
Minnesota has struggled at both offense and defense this season and as a result, has missed the playoffs. The Twins this season ranked 23rd in runs and 25th in batting average at .239. At the mound, the Twins were not much better, ranking 25th in ERA at 4.60 and 19th in home runs. The one upside to their pitching is they ranked third in walks; however, this would not prove to be good enough to help avoid runs. Minnesota will have to find more consistency at their plate and mound next season if it hope to find the playoffs.
Right-handed pitcher Pablo Lopez will be starting for the Twins on Friday.
Pablo Lopez:
- has a 5-4 record with an ERA of 2.84 and 65 strikeouts in 12 appearances this season.
- has a 0-2 record with an ERA of 5.40 and 22 strikeouts in 4 appearances versus the Diamondbacks in his career.
Arizona Diamondbacks vs. Minnesota Twins Prediction and Picks
Money Line Pick for Arizona Diamondbacks vs Minnesota Twins
- Twins Money Line (-132 ) (3 units)
The Diamondbacks are 3-7 in their last ten games versus the Twins. The Twins are 2-0 as favorites against the NL West at home this season. Neither team has much to play for in this series, but given the history between the two teams, I have to side with the Twins. Arizona has struggled this season at the mound and especially as of late. I believe the Twins will be able to take advantage of this and grab the close win.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,502.00 |
| 2 |  Pro Sports Picks | +1,421.00 |
| 3 |  Brick Haus Sports | +634.00 |
| 4 |  David Delano | +492.00 |
| 5 |  Michael Briggs | +355.00 |
Over/Under Pick for Arizona Diamondbacks vs Minnesota Twins
- Over 8 (-122) (4 units)
The Diamondbacks have an over/under record of 6-3-1 in their last ten games against the Twins. The Twins have an over/under record of 8-2 in their last ten games at home. Both teams this season are struggling at the mound but still finding some success at the plate. With neither team looking reliable at the mound I believe this will be a back and forth high scoring matchup.
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