Arizona Diamondbacks vs. Minnesota Twins Prediction and Picks - September 13, 2025
Diamondbacks vs. Twins Prediction and Picks - September 13, 2025
The Diamondbacks are facing off against the Twins in game two of their series at Target Field in Minneapolis, Minnesota; keep reading for our Diamondbacks versus Twins prediction. Arizona is fourth in the NL West with a record of 73-75. Minnesota is fourth in the AL Central with a record of 65-82. The Diamondbacks had a 1-2 record versus the Twins in 2024. The first pitch is scheduled for 7:10 p.m. EDT. Need some winners this baseball season? Check out our Free MLB Picks.
Diamondbacks’ Pitching Picks Up A Loss
The Diamondbacks are coming off a loss on Friday versus the Twins with a final score of 9-8. This would be the fourth loss for the Diamondbacks in their last five games. Arizona sits three spots out from a wild card position with their winning percentage of .493, trailing the Mets with a percentage of .514.
Arizona would need a lot of help to make the playoffs and after yesterday’s loss, it did not get much better. The Diamondbacks have been one of the more dominant offenses this season, ranking fifth overall in runs and 10th overall in batting average at .250. However, due to their poor pitching, much like we saw yesterday, the Diamondbacks have been unable to take advantage of their impressive scoring. Arizona ranks 23rd this season in ERA at 4.51 and have an ERA of 6.80 in their last five games.
Right-handed pitcher Ryne Nelson will be starting for the Diamondbacks on Saturday.
- is 7-3 with an ERA of 3.48, 118 strikeouts and 1 save in 30 appearances this season.
- is 0-2 with an ERA of 16.20 and 8 strikeouts in 2 appearances versus the Twins in his career.
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Twins’ Comeback Win
The Twins picked up an impressive win yesterday against the Diamondbacks with a final score of 9-8. This is only the third win for the Twins in their last 11 games. Minnesota is far removed from any chance at the postseason, but has been using the rest of their season as a chance to rotate in younger players for next season.
Minnesota grabbed a huge comeback loss yesterday against Arizona as they were down 6-2 at the end of the sixth inning. However, once the Twins faced off against the struggling Diamondbacks’ bullpen, they were capable of running up the score and grabbing the win. This is impressive as the Twins have struggled most of this season at the plate, ranking 23rd overall in runs and 22nd in batting average at .240.
Right-handed pitcher Joe Ryan will be starting for the Twins on Saturday.
- has a record of 13-8 with an ERA of 3.32 and 176 strikeouts in 28 appearances this season.
- has given up 4 runs on 6 hits with 5 strikeouts in 6 innings against the Diamondbacks in his career.
Arizona Diamondbacks vs. Minnesota Twins Prediction and Picks
Money Line Pick for Diamondbacks vs. Twins
- Twins Money Line (-136) (4 units)
The Twins are 3-0 as favorites against the NL West at home this season. The Diamondbacks have a record of 2-7 in their last nine games versus the Twins. Ryne Nelson seems to have a huge issue when facing off against the Twins as he has a record of 0-2 in two appearances with an ERA of 16.2. Nelson has allowed six runs per game in his two games against the Twins and will likely struggle against a Twins’ team that has looked confident at the plate in recent games.
Over/Under Pick for Diamondbacks vs. Twins
- Over 8.5 (+102) (5 units)
The Twins have an over/under record of 8-1 in their last nine games at home. The Diamondbacks have an over/under record of 7-3-1 in their last 11 games against the Twins. I do not doubt that Ryne Nelson will struggle against the Twins as he has in the past but Joe Ryan has also had issues in his career against Arizona, allowing four runs in his one game against them. With the starting pitchers looking unreliable as well as the bullpens, I have to take the over.
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