Arizona Diamondbacks vs. San Francisco Giants Prediction and Picks - September 10, 2025
The San Francisco Giants will continue their series against the Arizona Diamondbacks at Oracle Park, and we have you ready to go with the Diamondbacks vs the Giants prediction.
Opening Pitch is slated for 3:45 PM Eastern, and San Francisco took the first game of this series. Read on for the Diamondbacks vs Giants prediction and more free MLB picks.
This article was written before the completion of Tuesday's action.
Diamondbacks Look To Reclaim .500
Arizona got to work early, scoring four of its five runs over the first three innings. However, the offense did little work after that. The Diamondbacks finished with eight hits as two players finished with multiple hits at the plate. Ketel Marte led the way with three hits, and Gabriel Moreno added a home run in the 8th. Arizona struck out 10 times along the way. Nabil Crismatt got the start, and over four innings, he struck out three and allowed four runs.
LHP Eduardo Rodriguez is slated to start for the Arizona Diamondbacks. This season, Rodriguez has made 25 starts, posting a 7-8 record with a 5.22 ERA over 131.2 innings pitched. He has recorded 124 strikeouts and issued 53 walks, holding opposing hitters to a .248 batting average. While hits have been a problem, around six per start, Rodriguez has done well to limit the long ball, and he's averaging nearly seven strikeouts per game, and he's been tossing his best in daytime affairs.
On the road in 2025, Rodriguez holds the following splits:
- ERA: 5.14
- Opponent Batting Average (OBA): .308
- BB/K Ratio: 0.40
Arizona enters this contest averaging 5.48 runs per game, which lands them at 3rd in the league. The Diamondbacks hit well at the plate and are sitting 12th in overall batting average. That average has been higher on the road, with more than half of their extra-base hits coming away from their home crowd. They hit more in line with their season average in afternoon affairs, but home runs came at a much higher rate. Given that Arizona sits in the top five in home run rate and in the top 10 in doubles per game, they will look to continue their hot hitting here.
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Giants Vye Moving Up In NL West
San Francisco finished with 11 runs on 12 hits as they had three multi-run innings. The Giants struck out just six times as four batters finished with multiple hits at the plate. Jung Hoo Lee led the way with three hits, and he added a home run in the 2nd. In all, San Francisco finished with five home runs. Logan Webb got the start, and over six innings, he struck out seven and allowed one earned run.
RHP Carson Seymour is set to take the hump for the Giants on Wednesday. In 12 games and two starts, he currently holds a 4.25 ERA over 29.2 innings, with a 1.35 WHIP and 20 strikeouts to go with 12 walks issued. Home runs have been a problem at times this season, but Seymour has allowed just two over his last five contests. However, he's been his weakest both at home and in daytime contests.
At home this season, Seymour holds the following splits:
- ERA: 5.27
- Opponent Batting Average (OBA): .264
- WHIP: 1.61
San Francisco enters this contest averaging 5.0 runs per game, which lands them at 7th in the league. The Giants have struggled with consistency at the plate this season and are currently sitting in the bottom 10 in overall batting average. The Giants have been hitting even more weakly at home, but more than half of their home runs have come in front of their home crowd. San Francisco has been hitting their strongest in afternoon games this season. On the plus side, home runs have been coming at a much higher rate than the league average. San Francisco's problems begin at the plate, though. They are sitting in the bottom 10 in strikeout rate, but their ability to hit for extra bases has often made their offense lethal.
Diamondbacks vs. Giants Pick
Spread Pick for Diamondbacks vs. Giants
- Arizona ML
Arizona continues to hang around the top 10 in overall batting average, and that average has only climbed in daytime games over September. Seymour has been vulnerable to the long ball, and Arizona is launching over half of its home runs on the road this season. With the Giants struggling to find consistency at the plate and the Diamondbacks able to extend hits at a high rate, look for them to take care of business here.
Arizona ML
Total Pick for Arizona Diamondbacks vs San Francisco Giants
- Over 8.5
Rodriguez has been erratic all season long, and his road ERA sits above his season average. Not only that, but opponents were hitting around .275 for August. Seymour has seen his split high OBA when he's tossing at home, and he will face an Arizona team that has been red-hot at the plate this month. Look for both offenses to find their rhythm here early and push this number over the total.
Over 8.5
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