Baltimore Orioles vs. Chicago White Sox Picks and Prediction, Monday, September 15, 2025
In the series opener between two teams that are out of the playoff race, the Chicago White Sox (57-93) play host to the Baltimore Orioles (69-80). Both teams are in the basement of their respective divisions and each was swept in their last series. In this detailed Baltimore Orioles vs. Chicago White Sox prediction, you can see the full score info and pitching matchup as well as other free MLB picks.
The Orioles come into this series opener as a favorite posted at -140 with the White Sox at +125 and a total of 8 runs.
Orioles Swept After Sweep
The Orioles were swept in their last series on the road, facing the Toronto Blue Jays, while they were at home in their previous series, sweeping the Pittsburgh Pirates. In their last game, they lost to the Blue Jays 11-2, where Coby Mayo and Colton Cowser each had a solo HR. While Baltimore was swept in their last series, they are 6-4 in their last 10 games and tied with the L.A. Angels for the fourth-fewest wins in the AL.
- On the season, the Orioles rank tied for 21st in runs scored and 25th in team ERA.
- Gunnar Henderson (.271 16 HR 62 RBI) leads the team in RBI and batting average but is slumping this month, batting .143 with no HR and only one RBI.
- Jackson Holliday (.243 17HR 55 RBI) leads the club in HR and at bats and is riding a seven-game hitting streak and is batting .342 this month.
- On the season, the Orioles are 33-42 on the road.
Kyle Bradish (0-1 2.65 ERA 0.94 WHIP) gets the nod for Game 1 and in his last start was solid, giving up one run on four hits in seven innings in a 3-2 extra-inning win over the Pirates. This is only his fourth start of the season and the Orioles have won his last two where he gave up three runs in 11 innings of work.
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White Sox Lineup Struggles in Sweep
While the White Sox's pitching was not bad in their last series, they only totaled three runs in losing three road games to the Cleveland Guardians. In their last game, they lost 3-2, only had five hits, and Chase Meidroth had a solo HR, and Miguel Vargas had an RBI. Chicago is 5-5 in their last 10 games and has the fewest wins in the AL.
- On the season, the White Sox rank 26th in the Majors in runs scored and 20th in team ERA.
- Lenyn Sosa (.263 20 HR 68 RBI) leads the club in batting average, HR, and RBI and in 11 games this month is batting under the Mendoza line (.195) with two HR and seven RBI.
- Andrew Benintendi (.241 19HR 60 RBI) ranks second on the club in HR and RBI and has one HR and four RBI over the last six games.
- On the season, the Sox are 32-43 on the road.
Sean Burke (4-10 4.35 ERA 1.47 WHIP) takes the hill for Game 1 and in his last start, gave up three runs on five hits in 4 1/3 innings in a 6-5 win over the Tampa Bay Rays. The White Sox had lost his previous four starts even though he did not give up more than three runs in any of them.
Baltimore Orioles vs. Chicago White Sox Pick
Baltimore Orioles vs. Chicago White Sox
- Orioles -140 (4 units)
Both of these teams were swept in their last series and both are out of the playoff race. The White Sox only totaled three runs in the three losses in their last series and they will struggle at the dish again. Bradish has been solid in his three starts for the Orioles this season not giving up more than two runs in any of them and will pitch well again. Burke has given up three runs in each of his last two starts, where he totaled only eight innings. Regarding the Baltimore Orioles vs. Chicago White Sox prediction, Bradish will have the better outing and the Orioles will be better at the dish Add those things up, and you get a Baltimore win.
Over/Under Pick for Baltimore Orioles vs. Chicago White Sox
- Under 8 runs (4 units)
The total has gone Under for the last four games for the White Sox and that is the pick I am leaning towards in this series opener. The Sox only totaled three runs in their last three-game series and they will not score many runs in this game, facing Bradish, who has not given up more than two runs in any of his three starts this season. Burke has not been bad as of late, giving up three runs in his last two outings, but only lasted a total of eight innings. The Orioles will get some runs but not put up a high total and with Chicago continuing to struggle at the dish the Under is the pick for Game 1.
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