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Butler Bulldogs vs Villanova Wildcats Picks, Prediction, Odds, and Line Movement for Wednesday February 25 2026

By: Kyle Kargel Published 02/25/2026, 09:54 AM ET
Butler vs Villanova prediction

Butler vs Villanova picks are on my betting card as the Wildcats host the Bulldogs at Finneran Pavilion. If you are grinding through sharp college basketball picks, this Big East matchup stands out. Villanova is laying a solid number at home, and the first meeting gives us a clear blueprint of how this one can unfold.

TLDR - Picks and Prediction

  • Spread Pick: Villanova -9.5
  • Total Pick: Under 146.5
  • Projected Final Score: Villanova 78, Butler 66

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  • Villanova trailed 33-30 at halftime in the first meeting before winning the second half 55-34.
  • All five Villanova starters scored in double figures in that game.
  • Butler has won only one game all season when scoring fewer than 77 points.
  • The spread has moved from Villanova -11.5 to -9.5.
  • The total has dropped from 148.5 to 146.5.
  • Butler enters off two straight wins after a six-game losing streak.
  • Villanova shot just 40.7 percent overall and 25 percent from three in its last loss to UConn.

Odds and Line Movement

Current Odds

Market Butler Villanova
Spread +9.5 (-105) -9.5 (-115)
Total 146.5 (-115) 146.5 (-105)

Line Movement - Spread

Date Time Butler Villanova
02/24 03:43:39PM +9.5 (-105) -9.5 (-115)
02/24 02:51:30PM +10.5 (-105) -10.5 (-115)
02/24 02:51:24PM +10.5 (-110) -10.5 (-110)
02/24 02:35:38PM +11.5 (-110) -11.5 (-110)

Line Movement - Total

Date Time Over Under
02/25 03:49:33AM 146.5 (-115) 146.5 (-105)
02/24 02:55:20PM 147.5 (-110) 147.5 (-110)
02/24 02:35:38PM 148.5 (-110) 148.5 (-110)

Butler vs Villanova Game Preview and Analysis

Villanova enters at 21-6 overall and 12-4 in the Big East. In the first meeting, the Wildcats flipped a tight game into a blowout with a 17-2 run in the second half. They outscored Butler 55-34 after halftime. That kind of surge shows how quickly Villanova can separate when its defense locks in.

All five starters scored in double figures in that matchup. Bryce Lindsay had 18 points and Matt Hodge added 17. That balance makes Villanova tough to scheme against. When they share the ball and defend with discipline, they control pace and late-game possessions.

Butler comes in at 15-13 and 6-11 in conference play. The Bulldogs are playing better, winning two straight after a six-game skid. They just beat Xavier 80-75 behind 24 points from Michael Ajayi and 21 from Yohan Traore.

Still, Butler’s offense has a clear threshold. They have won only one game all season when scoring fewer than 77 points. That is a major concern against a Villanova team that can tighten up defensively at home, especially after a loss where they shot poorly from the field and from three.

Injuries matter here. Azavier Robinson is out for the season. Kevin Ndzie and Jack McCaffery are also out, and Evan Haywood is questionable. That trims depth and ball-handling. Villanova has no reported injuries, which is a big edge in a game where bench minutes can swing momentum.

The line has come down from -11.5 to -9.5. That gives me a better entry point on the home favorite. I see Villanova controlling tempo and limiting clean looks for Butler.

Key Injuries and Notes - BUT and NOVA

  • BUT: Azavier Robinson is out for the season with a wrist injury.
  • BUT: Kevin Ndzie and Jack McCaffery remain out.
  • BUT: Evan Haywood is questionable.
  • NOVA: No reported injuries.
  • Villanova had all five starters score in double figures in the first meeting.

Final Score Prediction

I expect Villanova to respond sharply at home after its loss to UConn. Butler will compete early, but depth and defensive control should decide it.

  • Projected Final Score: Villanova 78, Butler 66

ATS and Total Picks

  • ATS Pick: Villanova -9.5
  • Total Pick: Under 146.5
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