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Creighton at Xavier Prediction, Picks, and Odds Movement for December 17 2025

By: Kyle Kargel Published 12/17/2025, 09:32 AM ET

Tonight we have a battle on our hands in the Big East, and we will provide you with our Creighton vs Xavier picks and break down the matchups, a few stats to know, and provide a final score prediction.

Remember be sure to check out our hub for college hoops for more college basketball picks. Let's dive into the Creighton vs Xavier matchup for tonight.

TLDR - Picks and Prediction

  • Spread Pick: Xavier -2.5
  • Total Pick: Under 151
  • Projected Final Score: Xavier 72, Creighton 67

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Stats to Know for Creighton vs Xavier

  • Creighton has made at least one three-pointer in 1,066 straight games.
  • The Bluejays have hit five or more three-pointers in 81 consecutive games.
  • Xavier enters Big East play with an 8-3 record compared to Creighton’s 5-5 mark.

Odds and Line Movement

Team Spread Total
Creighton +2.5 (-115) Under 151 (-110)
Xavier -2.5 (-105) Over 151 (-110)

Line Movement - Spread

Date Time Creighton Xavier
12/17 09:04:20AM +3 (-102) -3 (-120)
12/17 09:03:08AM +3.5 (-114) -3.5 (-106)
12/17 09:02:44AM +3.5 (-115) -3.5 (-105)
12/16 10:01:29PM +2.5 (-106) -2.5 (-114)
12/16 09:46:30PM +2.5 (-115) -2.5 (-105)
12/16 09:45:37PM +1.5 (-106) -1.5 (-114)

Line Movement - Total

Date Time Over Under
12/16 09:29:56PM 150 (-110) 150 (-110)
12/16 02:37:27PM 149 (-110) 149 (-110)

Creighton vs Xavier Game Preview and Analysis

Creighton opens Big East play on the road at Xavier in a matchup that feels like an early tone-setter for both programs. The Musketeers are 8-3 entering conference action, while the Bluejays sit at 5-5 and are looking for consistency as league play begins.

The matchup begins with Creighton’s offensive profile. The Bluejays’ spacing and perimeter shooting can travel, and their long-standing three-point streaks introduce volatility into a short-spread road spot where a few made shots can swing the outcome late.

Injuries play a meaningful role in this handicap. Creighton is without Hudson Greer and Jackson McAndrew, thinning the rotation and making foul trouble more punitive if Xavier can extend possessions. Xavier’s injury list is lighter, but Gabriel Pozzato remains out and Kason Westphal is redshirting, placing added pressure on the primary rotation to control the glass and limit empty trips.

With Xavier owning the cleaner start to the season and holding home-court advantage, I trust the Musketeers to win the efficiency battle in a lower-tempo Big East opener.

Key Injuries and Notes (CRE and XAV)

  • Creighton: Hudson Greer out, Jackson McAndrew out.
  • Xavier: Gabriel Pozzato out, Kason Westphal is out (redshirt).

Final Score Prediction

Xavier 72, Creighton 67

ATS and Total Picks

  • Against the Spread: Xavier -2.5
  • Total: Under 151
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