Duke Blue Devils vs Arkansas Razorbacks Picks and Prediction - November 27, 2025

By: Dean Whitaker Published 11/27/2025, 09:35 AM ET
Karter Knox looks to lead Arkansas over Duke
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It's the ACC vs the SEC in college hoops action on Thursday evening, and we have a Duke vs Arkansas prediction ready to rock and roll. This contest will take place at the United Center in Chicago. Arkansas enters this game at 5-1 on the year, and they are off a 115-61 home win over Jackson State. Duke enters off a 93-56 home win over Howard to move to a perfect 7-0 on the year. These teams last met back in 2023, and Arkansas won that game at home by a score of 80-75. Continue reading to see our Duke vs Arkansas prediction.

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Duke Off To A Perfect  Start

Duke rolls into Thanksgiving week unbeaten at 7-0, most recently handling Howard with ease in a 93-56 win on November 23 in Durham. Cameron Boozer led the way with 26 points and 12 rebounds, while Pat Ngongba chipped in 16 points and five boards. The Blue Devils’ defense suffocated Howard, holding them to 30% shooting and forcing 12 turnovers. That performance capped off a dominant opening stretch where Duke has already beaten Kansas and Indiana State by double digits, setting the tone for their neutral-site clash with Arkansas in Chicago.

The Blue Devils’ offense has been one of the most efficient in the country, averaging 93.6 points per game while shooting 52.4% from the field. Boozer has been the centerpiece, putting up 21.1 points and 9.9 rebounds per game, while Ngongba adds 13 points and nearly seven rebounds. Isaiah Evans has chipped in 13 points per contest, and Caleb Foster has been steady in the backcourt. Duke’s depth is notable, with multiple freshmen contributing, including Dame Sarr and Nikolas Khamenia, who provide perimeter shooting and defensive versatility. The Blue Devils rebound well at 40.9 boards per game, giving them second-chance opportunities that fuel their high-scoring attack.

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Defensively, Duke has been elite, allowing just 57 points per game, the best mark in the nation. Opponents are shooting only 33% from the field and 24.7% from three, numbers that reflect how suffocating their rotations have been. Boozer’s length and Ngongba’s rim protection anchor the interior, while Evans and Sarr pressure guards on the perimeter. This balance of offensive firepower and defensive discipline has made Duke look like a complete team early in the season. Against Arkansas, the challenge will be containing the Razorbacks’ dynamic backcourt while maintaining their own offensive rhythm in a high-profile neutral-site showdown.

Arkansas Crushes Jackson State

Arkansas improved to 5-1 with a commanding 115-61 win over Jackson State on November 21 in Fayetteville, a game where the Razorbacks shot an incredible 64% from the field and buried nine threes at a 50% clip. Meleek Ewin was the spark off the bench, going 8-for-9 from the floor and finishing with a team-high 21 points. Karter Knox added a double-double with 17 points and 10 rebounds, while D.J. Wagner was perfect from the field, hitting all six of his shots for 16 points and seven assists. The Hogs dominated every phase, winning the rebounding battle 36-29 and dishing out 24 assists on 39 made baskets.

The Razorbacks’ offense has been explosive early in the season, averaging 91 points per game while shooting 49.9% from the field. Wagner and Acuff Jr. form a dynamic backcourt, combining for over 25 points per game, while Knox and Trevon Brazile provide size and scoring in the frontcourt. Ewin’s breakout against Jackson State highlighted the team’s depth, as Arkansas has multiple players capable of stepping into big roles. Free-throw shooting has been a strength as well, with the team hitting nearly 80% from the line, ranking ninth nationally. That efficiency gives them a reliable edge in close games and complements their fast-paced attack.

Defensively, Arkansas has been solid but not elite, allowing 70.3 points per game and ranking 77th nationally. Opponents are shooting 38.6% from the field, but perimeter defense remains a concern, with teams hitting 30.2% from three against them. Brazile’s rim protection and Knox’s rebounding help stabilize the interior, but the Razorbacks will need sharper rotations against Duke’s balanced offense. The win over Jackson State showed what Arkansas looks like when everything clicks — efficient shooting, strong ball movement, and contributions across the roster. To keep pace with Duke, the Razorbacks will need that same level of execution while tightening up defensively in a marquee neutral-site matchup.

Duke vs Arkansas Pick

Duke vs Arkansas Spread Pick

  • Duke -10.5 (4 Units)

Laying the points with Duke at -10.5 makes sense given how dominant the Blue Devils have looked on both ends of the floor. They’re averaging nearly 94 points per game while shooting over 52% from the field, and Cameron Boozer has been a force with 21 points and 10 rebounds per game. Pat Ngongba adds interior scoring and rim protection, while Isaiah Evans and Caleb Foster provide perimeter balance. Arkansas has offensive talent, but Duke’s depth and efficiency make them difficult to keep pace with, especially in a neutral-site setting where the Blue Devils’ defense can dictate tempo.

On the defensive side, Duke has been suffocating, allowing just 57 points per game, the best mark in the nation. Opponents are shooting only 33% from the field and under 25% from three, which spells trouble for an Arkansas team that relies heavily on its freshman backcourt to generate offense. Even if the Razorbacks get hot, Duke’s ability to rebound and limit second-chance opportunities tilts the matchup. With Boozer and Ngongba controlling the paint and the guards forcing turnovers, Duke has the tools to stretch this game beyond double digits and cover the -10.5 spread.

Duke vs Arkansas Over/Under Pick

  • Under 158 (5 Units)

The Under 158 feels like the right angle because Duke’s defense has been suffocating, holding opponents to just 57 points per game on 33% shooting, while Arkansas, though explosive offensively, averages 91 points per game but has been inconsistent against disciplined defenses. Neutral-site games often slow down, and Duke’s ability to control tempo with Cameron Boozer and Pat Ngongba inside should limit Arkansas’ transition chances. With the Blue Devils grinding possessions and the Razorbacks likely struggling to maintain efficiency against elite defensive pressure, this matchup sets up for a total that stays below 158.

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