Louisville vs. Arkansas, Picks, Odds, Line Movement, and Prediction, Wednesday, Dec. 3, 2025
The ACC/SEC Challenge returns on Wednesday in this Louisville vs. Arkansas prediction. John Calipari's No. 25 Razorbacks are 5-2, looking to remain undefeated at home. Pat Kelsey and his No. 6 Cardinals (7-0) are looking to stay undefeated. These teams will meet for the first time since 2022 at 7:15pmET from Fayetteville, Ark. Keep reading to find the prediction, spread and total below. We also have more free college basketball picks at Stat Salt.
Quick Picks and Prediction on Louisville vs. Arkansas
If you're in a rush, we have the guide to what you're looking for. Check out the prediction, pick and total along with line movements below.
- Arkansas 73-Louisville 68
- Under 165.5
- Arkansas +3.5
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Louisville vs. Arkansas Odds and Line Movement
Keep reading for more on the opening lines and current odds in the Louisville vs. Arkansas prediction. We also have the odds for the totals and money line.
Opening Odds for Louisville vs. Arkansas
- Spread: Louisville -3.5 (-110)/Arkansas +3.5 (-110)
- ML: Louisville -188/Arkansas +155
- Total: o165.5 (-110)/u16.5 (-110)
(odds from FanDuel)
Key Matchups for Louisville vs. Arkansas
Cards running on all cylinders
Louisville hasn't played since Nov. 26, when it defeated NJUIT 104-47 at home as a 44-point favorite. Ryan Conwell led the way with 32 points, nine rebounds and six assists. Louisville has won all seven games they've played, including defeating Kentucky by eight on Nov. 11 and Cincinnati on the road on Nov. 21. The No. 6 Cardinals also rank eighth on KenPom, second in Adjusted Offensive efficiency and 30th in Adjusted Defense.
The Cards have been winning without the help of 6-10 center Kasean Pryor, who was limited last year to 12 points and 6.1 rebounds in seven games due to injury. He's played in just four games and is listed as questionable with a concussion. Conwell leads the Carsd with 120.1 points and adds 5.4 rebounds, while shooting 46.5% from the field and 45.2% from long range.
Big test for Razorbacks
You can never count out a John Calipari team. They have two losses against elite programs. On Nov. 8, they fell to Michigan State 69-66 and on Nov. 27 lost to Duke from Chicago. Darius Acuff Jr. led the Hogs with 21 points and five assists, while Trevon Brazile added 11 points and 11 rebounds. Arkansas shot just 41% from the field and the Blue Devils shot 49%. Cam Boozer led Duke with 35 points and nine rebounds on 13-of-18 shooting.
Mark Thomas, a 6-5 freshman guard, leads the Razorbacks in scoring with 17.6 points with 3.9 assists, while Acuff Jr. adds 17.4 points and 4.4 assists, while shooting 45% from three-point range. Arkansas ranks 36th on KenPom, 47th in Adjusted Offense and 35th in Adjusted Defense.
Betting Trends for Louisville vs. Arkansas
Louisville:
- 4-1 ATS last 5 games.
Arkansas:
- 8-3 ATS last 11 games.
- 5-1 Under last 6 games.
Key Injuries and Analysis for Louisville vs. Arkansas
Louisville:
- F K. Pryor (concussion) is questionable. Has played in just four games this season.
Arkansas:
- no key injuries.
Louisville vs. Arkansas ATS and Over/Under Betting Picks
Check out the analysis below of the pick in the Louisville Cardinals vs. the Arkansas Razorbacks. We'll also have the total and analysis using logic, intangibles and stats.
Louisville vs. Arkansas Spread
- Arkansas +3.5 (4 units)
Total for Louisville vs. Arkansas
- Under 165.5 (4 units)
Louisville vs. Arkansas Final Score Prediction
- Arkansas 73-Louisville 68
Louisville is a very good basketball team, but Arkansas needs this game after competitive losses to Duke and Michigan State. As good as Louisville is, their strength of schedule is a weak one, ranking 345th in SOS on KenPom, while Arkansas is at 216. This is what teams are doing nowadays, playing a few really good squads and taking on low-ranked teams at home. Arkansas needs to put together a strong resume' and while they have plenty of chances in the SEC to do that, this would be a great non-conference win for Calipari's squad to add to it. Even though the pace should be fast, Arkansas has gone under in five of its last six games, while Louisville has gone under in three straight games.
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