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Michigan State Spartans vs Purdue Boilermakers Picks, Prediction, Odds, and Line Movement for Thursday February 26 2026

By: Kyle Kargel Published 02/26/2026, 10:18 AM ET
Michigan State vs Purdue prediction

Michigan State vs Purdue picks are front and center in this Big Ten showdown, and if you are looking for sharp college basketball picks, this matchup between two projected protected seeds deserves a deep, numbers-driven look.

TLDR - Picks and Prediction

  • Spread Pick: Michigan State +7.5
  • Total Pick: Under 141.5
  • Projected Final Score: Purdue 69, Michigan State 65

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  • Purdue is just 4-9 against the spread in its last 13 games.
  • Purdue is 1-6 against the number at Mackey Arena in Big Ten play this season.
  • Michigan State allows just 66.1 points per game, ranking 20th nationally.
  • Jeremy Fears Jr leads the nation with 9.2 assists per game.
  • Purdue shot 65 percent from the floor in a 93-64 win over Indiana.
  • Trey Kaufman-Renn has scored 47 points over his last two games.

Odds and Line Movement

Current Odds

Market Michigan State Purdue
Spread +7.5 (-110) -7.5 (-110)
Total Over 141.5 (-110) Under 141.5 (-110)

Line Movement - Spread

Date Time Michigan State Purdue Public
02/25 11:44:48AM +6.5 (-120) -6.5 (-102)
02/26 09:03:35AM +7.5 (-110) -7.5 (-110) PUR 65%, PUR 58%

Line Movement - Total

Date Time Over Under Public
02/25 11:44:48AM 140.5 (-110) 140.5 (-110)
02/26 09:31:44AM 142.5 (-110) 142.5 (-110) OV 93%, OV 50%

Michigan State vs Purdue Game Preview and Analysis

Purdue may be eyeing a No. 1 seed with a strong finish. The Boilermakers are coming off dominant wins over Iowa, Michigan and Indiana. In the 93-64 blowout of Indiana, they shot 65 percent from the field. That was likely their best effort of the season.

Trey Kaufman-Renn has been on a tear, scoring 47 points over the last two games. That surge is important because Oscar Cluff has struggled to find consistency. Cluff has reached double figures just once in his last nine games.

Purdue still runs the offense through Braden Smith and Fletcher Loyer. However, Tom Izzo has shown he can contain those guards. The problem for Michigan State in past meetings was Zach Edey. He is no longer in the picture.

Michigan State has built momentum with wins over UCLA and Ohio State. The Spartans beat UCLA 82-59 and then grinded out a 66-60 win over Ohio State. Jeremy Fears Jr is the engine. His 9.2 assists per game lead the nation, and he controls tempo.

Izzo’s defense allows just 66.1 points per game. That matters in a game lined in the low 140s. Purdue has not covered consistently, especially at home in league play. Laying more than seven points against a disciplined defensive team is a big ask.

Key Injuries and Notes - MSU and PUR

  • No major injuries were noted for either side in the provided information.
  • Purdue relies heavily on Kaufman-Renn, Smith and Loyer for scoring balance.
  • Michigan State’s identity remains defense and playmaking from Fears.

Final Score Prediction

I expect a tight game where defense and half-court execution decide the outcome.

  • Purdue 69, Michigan State 65

ATS and Total Picks

  • Spread: Michigan State +7.5
  • Total: Under 141.5
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