Mississippi State Bulldogs vs Iowa State Cyclones Prediction and Picks - November 10, 2025
Monday evening on the college hardwood, and we have a Mississippi State vs Iowa State prediction ready to rock and roll. The Bulldogs are 1-0 on the year after a solid 86-62 home win over North Alabama. The Cyclones are off a 102-62 home win over Grambling, which pushed them to 2-0 on the year. These teams last met in 2021 and Mississippi State won that game at home by a score of 95-56. Read on to see our Mississippi State vs Iowa State prediction.
If you are struggling to pick winners, you've come to the right place. We have the best NCAAB Predictions available.
Bulldogs Rip North Alabama At Home
Mississippi State heads into Monday night with a 1–0 record after a strong second-half surge helped them pull away from North Alabama in their opener. The Bulldogs turned a slim halftime lead into a 24-point win, thanks to a breakout performance from junior guard Josh Hubbard, who poured in 27 points and dished out eight assists. Head coach Chris Jans praised the team’s ball security—just seven turnovers—and their dominance on the glass, where they posted a 53–36 rebounding edge. It’s early, but this group looks deeper and more composed than last year’s squad that faded late in SEC play.
Offensively, the Bulldogs shot 43.7% from the field and knocked down 8 of 27 from deep, with room to grow from the perimeter. Their free throw shooting was shaky at 66.7%, but they made up for it with hustle plays and second-chance points. Ja’Borri McGhee added 14 off the bench in his debut, and Quincy Ballard chipped in with 8 points on 4-of-5 shooting. The team’s ability to rotate 11 players and still maintain tempo could be a key factor against Iowa State’s pressure defense. Hubbard’s leadership and shot creation will be tested, but he’s shown he can carry the load.
Defensively, Mississippi State held North Alabama to just 36.9% shooting and forced 13 turnovers, including nine steals. They allowed only seven assists and limited transition chances, showing a commitment to half-court discipline. The Bulldogs will need that same intensity against an Iowa State team that’s averaging 95 points per game and shooting over 53% from the field. If Mississippi State can control the boards and keep the Cyclones out of rhythm early, they’ll have a chance to grind this one out. But they’ll need to be sharper from the arc and the stripe to keep pace if it turns into a shootout.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Sean Higgs | +1,222.00 |
| 2 |  Rob Vinciletti | +809.00 |
| 3 |  Joe Duffy | +666.00 |
| 4 |  Mark Ruelle | +579.00 |
| 5 |  David Hess | +572.00 |
Sign Up for StatSalt News Alerts, Get Free Picks and Discounts
Subscribe Now
Cyclones Off To A 2-0 Start
Iowa State comes in ranked No. 16 nationally and riding high after back-to-back blowout wins over Fairleigh Dickinson and Grambling. The Cyclones have averaged 95 points through two games and shot a blistering 53.4% from the field. Milan Momcilovic leads the way with 20 points per game, while Joshua Jefferson and Tamin Lipsey round out a trio that’s been efficient and aggressive. Lipsey, returning from a preseason knee injury, has looked sharp—shooting 60% from the floor with 11 assists and 10 rebounds through two games. Head coach T.J. Otzelberger has this group playing fast, connected, and confident.
The Cyclones have dominated on both ends, holding opponents to just 56 points per game and limiting them to 33% shooting from deep. Their defensive rotations have been crisp, and they’ve forced turnovers in bunches, including five steals from Lipsey in each of the first two games. Jefferson has been a force on the glass, averaging nine boards, and the team’s ability to push off rebounds has led to easy buckets in transition. Iowa State’s depth and conditioning have stood out early, and they’ll look to keep the tempo high against a Mississippi State team that prefers a more physical, half-court style.
This game marks Iowa State’s first road test of the season, though Otzelberger is no stranger to the Sanford Pentagon from his South Dakota State days. The Cyclones will need to stay composed if Mississippi State slows the pace and forces them into longer possessions. But if Lipsey continues to control the tempo and Momcilovic gets going early, Iowa State has the firepower to pull away. Expect a fast start and plenty of pressure defense as the Cyclones try to make a statement against a physical SEC opponent.
Mississippi State vs Iowa State Pick
Mississippi State vs Iowa State Spread Pick
- Iowa State -5 (2 Units)
Iowa State -5 looks like a sharp play given how dominant the Cyclones have been through their first two games. They’ve averaged 95 points per contest while shooting over 53% from the field, and their defensive pressure has been relentless—holding opponents to just 56 points per game. Tamin Lipsey’s return has stabilized the backcourt, and Milan Momcilovic has emerged as a go-to scorer with 20 points per game. Against a Mississippi State team that struggled from the free throw line and shot just 43.7% in its opener, Iowa State’s tempo and shot-making could create separation early.
Mississippi State has size and rebounding strength, but Iowa State’s ball movement and transition game are built to exploit slower, half-court defenses. The Cyclones have forced double-digit turnovers in both games and have the depth to keep pressure on for 40 minutes. If Lipsey controls pace and Jefferson continues to dominate the glass, Iowa State should be able to dictate tempo and wear down the Bulldogs. On a neutral floor, with momentum and offensive rhythm on their side, the Cyclones are well-positioned to cover the number.
Mississippi State vs Iowa State Over/Under Pick
- Under 151 (2 Units)
Under 151 feels like the right lean in a matchup where both teams bring defensive structure and physicality to the floor. Mississippi State held North Alabama to just 36.9% shooting in their opener and thrives on slowing the pace, crashing the glass, and forcing half-court possessions. Iowa State has looked explosive early, but they’ve also held opponents to just 56 points per game and pride themselves on ball pressure and forcing turnovers. With both teams likely to grind through stretches and limit transition opportunities, this one could settle into a defensive rhythm that keeps the total in check.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $200 in Bonus Bets Win or Lose
