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USC at San Diego Prediction, Picks and Odds for Tuesday December 9 2025

By: Kyle Kargel Published 12/09/2025, 09:48 AM ET
USC guard Chad Baker-Mazara defends

USC vs San Diego prediction for Tuesday night’s West Coast clash at Jenny Craig Pavilion, where the Trojans look to continue their dominant offensive start against a Toreros squad trying to halt a four game skid. Full odds, line movement tables, matchup insights, and our projected final score are below. For more breakdowns and analytics-driven previews, visit the latest college basketball picks.

Quick Picks and Prediction

  • Side: USC -16.5
  • Total: Over 159.5
  • Projected Final Score: USC 91, San Diego 72

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Odds and Line Movement

USC has opened as a significant road favorite, and the market has held firm around the mid teens as bettors anticipate a pace-heavy offensive showcase. Totals have climbed steadily, reflecting USC’s fast tempo and San Diego’s defensive struggles.

Opening Odds

Market USC San Diego
Spread -16 (-110) +16 (-110)
Total Over 162 (-110) Under 162 (-110)

USC vs San Diego Current Odds

Market USC San Diego
Spread -16.5 (-110) +16.5 (-110)
Total Over 159.5 (-105) Under 159.5 (-115)

Line Movement - Spread

Date Time USC San Diego Public ($, #)
12/08 10:32:17pm -16 (-110) +16 (-110)
12/08 10:30:02pm -15.5 (-110) +15.5 (-110)
12/08 10:31:49pm -16.5 (-102) +16.5 (-120)
12/08 08:21:42pm -16 (-110) +16 (-110)
12/08 08:20:57pm -17 (-102) +17 (-120)
12/08 08:20:33pm -17.5 (-110) +17.5 (-110)
12/08 03:06:08pm -17 (-102) +17 (-120)
12/08 03:05:29pm -16 (-110) +16 (-110)

Line Movement - Total

Date Time Over Under Public ($, #)
12/09 09:06:01am 159.5 o(-105) 159.5 u(-115)
12/09 09:05:44am 159 o(-110) 159 u(-110)
12/09 09:04:33am 160 o(-110) 160 u(-110)
12/08 10:43:09pm 161 o(-110) 161 u(-110)
12/08 04:08:26pm 162 o(-110) 162 u(-110)
12/08 03:57:55pm 162 o(-110) 162 u(-110)
12/08 03:05:29pm 162 o(-110) 162 u(-110)

USC vs San Diego Key Matchups and Handicap

USC enters Tuesday night looking every bit like a rising Big Ten contender, armed with elite scoring talent and a blistering tempo that has overwhelmed mid major defenses all season. Eric Musselman’s 8–1 squad has already posted 94+ points three times and topped 80 in seven of nine contests, riding a perimeter and wing trio that few teams can match.

Chad Baker-Mazara (20.9 ppg) and Rodney Rice (20.3 ppg) headline a Trojans attack that thrives in transition and isolation, while Ezra Ausar (15.9 ppg) brings power scoring inside. Jacob Cofie anchors the interior defensively with 7.0 rebounds and 2.4 blocks per game, giving USC enough rim protection to fuel its runout game.

Against that profile, San Diego faces a steep challenge. The Toreros limp in at 3–5 with a four game losing streak, surrendering 76+ in each outing. Their offense revolves around perimeter creation from Juan Sebastián Gorosito, Ty-Laur Johnson, and Toneari Lane, all scoring around 11 points per game, but the unit lacks USC’s athleticism and shot making depth.

USC’s biggest concern entering the matchup is health. Freshman phenom Alijah Arenas remains out until roughly mid January after knee surgery, but more pressing is the status of Rodney Rice, who re aggravated a shoulder injury in late November and remains day to day. Even if available, Rice may see reduced minutes, placing more creation burden on Baker-Mazara and Ausar.

San Diego’s roster appears near full strength, with forward Gavin Ripp returning from ankle issues, but the matchup remains lopsided. The Toreros have been outmuscled on the glass and have not faced an offense anywhere near USC’s level of shot creation and transition pressure.

  • USC is 5–4 ATS this season.
  • San Diego is 2–5 ATS during its 3–5 start.
  • Six of USC’s nine games have gone over the total.

USC vs USD Key Injuries and Notes

  • USC remains without Alijah Arenas (knee, mid January timeline).
  • Rodney Rice is day to day with a shoulder injury.
  • San Diego enters mostly healthy but remains overmatched in size and athleticism.

ATS and Total Picks

San Diego has dropped its last four contests by margins of 4, 15, 14, and 17 points, but none of those opponents bring USC’s combination of length, pace, and scoring efficiency. The Trojans should overwhelm USD’s guards, generate a steady diet of transition chances, and dominate the paint.

With USC pushing pace and San Diego capable of hitting enough threes to avoid extended scoring droughts, the over remains attractive despite the lofty number.

  • Side Pick: USC -16.5
  • Total Pick: Over 159.5

USC vs San Diego Final Score Prediction

Projected Final Score: USC 91, San Diego 72

Stats to Know for USC vs San Diego

  • USC averages 89.0 points per game.
  • The Trojans allow 78.2 points per game, contributing to a 6–3 O/U mark.
  • San Diego has surrendered 76+ points in four straight games.
  • USC has topped 80 points in seven of nine matchups this season.
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