Xavier Musketeers vs Creighton Bluejays Picks, Prediction, Odds, and Line Movement for Wednesday January 21 2026
Xavier vs Creighton picks headline Wednesday night in Omaha as the Musketeers head to CHI Health Center to face a Bluejays team priced as a strong home favorite. I am breaking this matchup down strictly from a betting perspective for readers looking to find value in tonight’s college basketball picks.
TLDR - Picks and Prediction
- Spread Pick: Xavier +7.5
- Total Pick: Over 155.5
- Projected Final Score: Creighton 82, Xavier 76
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Stats to Know and Betting Trends for Xavier vs Creighton
- Creighton is laying a full 7.5 points at home after beating Xavier by 41 in the earlier meeting.
- Xavier has scored 89 and 97 points in its last two home wins.
- Xavier’s last five games have featured fast tempos and high possession counts.
- Creighton has played multiple games that have pushed past 150 total points, including recent overtime and road shootouts.
- Both teams have been involved in Big East games where defensive consistency has lagged behind offensive execution.
Odds and Line Movement
Current Odds
| Team | Spread | Total |
|---|---|---|
| Xavier | +7.5 (-110) | Over 155.5 (-115) |
| Creighton | -7.5 (-110) | Under 155.5 (-105) |
Line Movement - Spread
| Date | Time | Xavier | Creighton |
|---|---|---|---|
| 01/20 | 04:37 PM | +7.5 (-102) | -7.5 (-120) |
| 01/20 | 09:23 PM | +7.5 (-110) | -7.5 (-110) |
| 01/21 | 04:06 AM | +6.5 (-102) | -6.5 (-120) |
| 01/21 | 09:04 AM | +7.5 (-110) | -7.5 (-110) |
Line Movement - Total
| Date | Time | Over | Under |
|---|---|---|---|
| 01/20 | 04:37 PM | 154 (-110) | 154 (-110) |
| 01/20 | 05:13 PM | 155 (-115) | 155 (-105) |
| 01/20 | 06:15 PM | 156 (-115) | 156 (-105) |
| 01/21 | 04:06 AM | 155 (-115) | 155 (-105) |
Team vs Team Game Preview and Analysis
Xavier vs Creighton sets up as another Big East game where pace and shot-making are likely to decide the outcome. Xavier’s recent stretch shows just how high the offensive ceiling can be when the Musketeers are making shots and pushing tempo. The flip side is that their defense has struggled on the road, which is why the spread is sitting north of seven.
Creighton has been just as volatile. The Bluejays have been involved in multiple games where scoring snowballed quickly, especially at home when the threes start falling and the whistle becomes part of the game. That style creates separation, but it also leaves the door open for underdogs that can trade buckets.
The earlier blowout between these teams looms large in the number, but Xavier’s recent scoring form makes it harder to expect another runaway. If the Musketeers can rebound well enough and avoid extended empty stretches, they have a realistic path to stay within the number even if Creighton controls the game.
XU and CREI Key Injuries and Notes
- Gabriel Pozzato is out for Xavier.
- Kason Westphal is out and redshirting for the season.
- Creighton is not listing a major rotation injury for this matchup.
Final Score Prediction
Creighton 82, Xavier 76
ATS and Total Picks
- ATS Pick: Xavier +7.5
- Total Pick: Over 155.5
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