Arizona State Sun Devils vs Colorado Buffaloes Prediction and Picks - November 22, 2025
Saturday evening Big 12 College football action, and we have an Arizona State vs Colorado prediction locked and loaded for you. Arizona State comes in at 7-3 on the season, and they are off a 25-23 home win over West Virginia. The Buffaloes are off a 29-22 road loss to West Virginia, and they are now at 3-7 on the year. These teams last met back in 2023, and Colorado won that game on the road by a score of 27-24. Will Arizona get some revenge in this one? Read on to see our Arizona State vs Colorado prediction.
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Sun Devils Win Tight One Against West Virginia
Arizona State’s most recent game came on November 15, when the Sun Devils edged West Virginia 25-23 in Tempe. Quarterback Jeff Sims accounted for 288 total yards and three touchdowns, while kicker Jesus Gomez nailed a 49-yard field goal in the final minutes to secure the win. The defense sealed it with a late interception, keeping ASU’s Big 12 title hopes alive despite blowing a 12-point lead in the fourth quarter.
Sims has stepped in admirably with Sam Leavitt out for the year, throwing for 566 yards and five touchdowns while rushing for 411 yards and two scores. Running back Raleek Brown has been the steady force in the backfield, piling up 823 yards at 5.5 yards per carry. In the passing game, Jordyn Tyson (628 yards, 8 TDs) has been the big-play threat when healthy, while Chamon Metayer (370 yards, 4 TDs) and Derek Eusebio (197 yards, 1 TD) provide depth. ASU averages 401.2 yards per game, with a strong balance between the run and pass, though their scoring output sits at 24.7 points per game.
Defensively, the Sun Devils have been solid, allowing just 343.4 yards per game. Their run defense has been a strength, ranking 28th nationally at 117.7 yards allowed per contest, while the secondary has been more vulnerable at 225.7 yards per game. They’ve held opponents to 23.6 points per game and forced seven takeaways, showing resilience in tight contests. Against Colorado, ASU will look to lean on Sims’ dual-threat ability and Brown’s consistency, while trusting their defense to contain a Buffaloes offense that has struggled to find rhythm.
Colorado Fights Hard But Comes Up Short In Loss To West Virginia
Colorado last played on November 8, 2025, falling 29-22 at West Virginia. Freshman quarterback Julian Lewis threw for 299 yards and two touchdowns in his first start, but the Buffaloes couldn’t overcome a shaky offensive line and a defense that allowed 421 total yards. Despite a late rally, Colorado dropped to 3-7 overall and 1-6 in Big 12 play, eliminating them from bowl contention.
The Buffaloes’ offense has been inconsistent all season, averaging just 22 points per game. Quarterback Kaidon Salter has thrown for 1,242 yards and 10 touchdowns but also six interceptions, while Lewis has shown promise with 428 yards and three scores in limited action. Wideouts Omarion Miller (652 yards, 7 TDs) and Jimmy Williams (450 yards, 4 TDs) headline the receiving corps, while Seth Brown has added 316 yards and two scores. The rushing attack has been limited, with Micah Welch leading at 313 yards and two touchdowns, leaving much of the offensive burden on the passing game.
Defensively, Colorado has struggled, allowing 420.7 yards per game and 30 points per contest. Their run defense has been particularly porous, giving up 210.9 yards per game, ranking 132nd nationally. The secondary has been better, allowing 209.8 yards per game, but with only five takeaways all season, the Buffs have struggled to flip momentum. Against Arizona State, Colorado will need Lewis to continue showing poise while hoping their defense can slow down Sims and Brown enough to keep the game competitive in their final home appearance of 2025.
Arizona State vs Colorado Pick
Arizona State vs Colorado Spread Pick
- Colorado +7 (3 Units)
Colorado +7 looks very strong with Julian Lewis as the starter. He’s given the Buffaloes’ offense a spark, completing nearly 59% of his passes for 428 yards and three touchdowns in limited action. With Lewis under center, Colorado can lean on its best weapons—Omarion Miller (652 yards, 7 TDs) and Jimmy Williams (450 yards, 4 TDs)—to attack an Arizona State secondary that’s allowing over 225 passing yards per game. That vertical threat makes the Buffs more dangerous than the line suggests, especially against a Sun Devils team averaging just 24.7 points per game.
The situational angle also favors Colorado. ASU’s defense is solid against the run, but they haven’t consistently put opponents away, and their offense isn’t built to create separation. Colorado’s defense has struggled, but if Lewis sustains drives and avoids turnovers, the Buffs have enough firepower to keep this game close. With the added boost at quarterback and a full touchdown cushion, backing Colorado +7 feels like value in a matchup that profiles as competitive throughout.
Arizona State vs Colorado Over/Under Pick
- Under 46.5 (1 Unit)
The Under 46.5 makes sense because neither offense has shown the consistency to push this game into a shootout. Arizona State averages just 24.7 points per game, leaning on Jeff Sims’ dual-threat ability and Raleek Brown’s ground production, while Colorado has been even less reliable, scoring only 22 points per game and struggling to establish balance. The Buffaloes haven’t topped 30 points since early in the season, and their run game ranks outside the top 100 nationally. On the other side, ASU’s defense is strong against the run, and Colorado’s defense—though leaky—has at least kept opponents from completely blowing games open. With both teams prone to long, grinding drives and stalled possessions, the matchup profiles as a lower-scoring battle that stays under the number.