Arizona State vs Kansas Picks and Prediction for Saturday September 19 2026

The Arizona State Sun Devils face the Kansas Jayhawks at Wembley Stadium in London, England, on Saturday, September 19, 2026. Kickoff is scheduled for 12:00 PM ET. Arizona State enters needing a response after suffering a 48-20 road loss to No. 10 Texas A&M, while Kansas is also trying to rebound after falling 38-21 to No. 23 Missouri. With both Big 12 teams coming off losses, the neutral-site setting adds another variable to an important early-season matchup. At the time of this writing the odds were not released. Be sure to check out our free college football picks for more NCAAF predictions throughout the season.

Arizona State Needs a Defensive Response

Arizona State's trip to Texas A&M produced a difficult result, with the Sun Devils falling 48-20. Giving up 48 points immediately raises questions entering another matchup against a Big 12 opponent capable of creating offensive pressure.

There is an important difference this week. Arizona State won't be dealing with the same hostile road environment it faced in College Station. Wembley Stadium makes this a neutral-site game, removing the conventional home-field advantage Kansas would normally receive.

The Sun Devils still need substantial defensive improvement. If Arizona State allows Kansas to consistently generate explosive plays and establish an early lead, the game could resemble last week's loss. Keeping the Jayhawks within one possession becomes critical.

Kansas Looks to Rebound After Rivalry Loss

Kansas also enters off a disappointing result after losing 38-21 to Missouri. The Jayhawks entered that rivalry matchup undefeated but couldn't keep pace once Missouri took control.

This becomes an important early test of Kansas' ability to respond. The Jayhawks aren't playing in Lawrence, meaning the normal home-field edge disappears. Traveling internationally also creates unusual preparation demands for both programs.

Kansas nevertheless draws the more favorable matchup based on what happened last week. Arizona State surrendered 48 points, and the Jayhawks should have opportunities to attack a defense coming off a difficult performance.

Arizona State vs Kansas Picks and Prediction

Pick: Kansas -3 or Better

Take Kansas if the Jayhawks are favored by -3 or less. Neither team deserves a huge amount of trust after last week's losses, but Arizona State's defensive performance against Texas A&M is the larger concern. Kansas should have enough offensive capability to exploit those issues, and laying no more than a field goal keeps the price manageable despite the neutral field. Kansas is my straight-up winner as well.

Pick: Over 55.5

Take the Over if the total is set at 55.5 or lower. Arizona State just participated in a 68-point game, while Kansas and Missouri combined for 59. Both defenses showed vulnerabilities against stronger competition, and the neutral-site environment makes me less interested in assuming either defense suddenly controls this matchup. A projected Kansas 31, Arizona State 27 puts this narrowly above the target.

Final Picks: Kansas -3 or Better and Over 55.5