Colorado vs. West Virginia Prediction and Picks for Saturday, November 8th, 2025

By: Trenton Pruitt Published 11/06/2025, 08:53 PM ET
Colorado vs. West Virginia Prediction
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Neither the Colorado Buffaloes (3-6, 1-5 B12) nor the West Virginia Mountaineers (3-6, 1-5 B12) has a shot at the conference title this year, but this should still be an evenly-matched conference clash on Saturday. We’ve got you covered with our Colorado vs. West Virginia prediction. Kickoff is scheduled for 12:00 ET from Milan Puskar Stadium in Morgantown, WV. Don’t get sacked this football season! Try our College Football Picks!

Buffaloes Hammered By the Wildcats

It wasn’t long ago that Coach Deion Sanders and the Colorado Buffaloes were the talk of the town, but at this point, the program finds itself as a bottom-feeder in the Big 12. The Buffs enter the weekend at 3-6, which includes their 1-5 conference mark. That lone win came against Iowa State (24-17), but they’ve since dropped back-to-back games against Utah (53-7) and Arizona (52-17), more recently. From a sports betting perspective, Colorado is 3-5-1 ATS and 5-4 to the under.

It has been a revolving door at quarterback for the Buffaloes this season, but it’s confirmed that true freshman Julian Lewis will start this weekend. He has thrown for 129 yards on a 52.4% completion rate with one touchdown. RB Micah Welch has spearheaded the rushing attack, gaining 313 yards and two touchdowns on 78 carries (4.0 YPC). Out wide, WR Omarion Miller leads the way with 521 yards and six touchdowns on 28 catches.

  • Offensively, the Buffs are scoring 22.0 points per game (95th), while averaging 329.8 yards per week (104th).
  • Defensively, they are 97th in the country this year, conceding 30.1 points per game. They’re allowing 426.6 yards per contest, which is 113th.

Mountaineers Take Down the Cougars

Meanwhile, things haven’t gone much better for Coach Rich Rodriguez and his West Virginia Mountaineers this season. They come into the weekend at 3-6, with a 14th-place conference record of 1-5. However, the vibes may be shifting as WVU just beat Houston in a 45-35 road game last time out. The Mountaineers are 5-4 ATS and 5-4 to the under.

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QB Scotty Fox Jr. led the Mountaineers to the big win last weekend, and he has now thrown for 623 yards on a 59.1% completion rate, adding four touchdowns and two picks. WR Cam Vaughn is the top target out wide, hauling in 28 passes for 444 yards and four touchdowns. RB Diore Hubbard leads the rushing attack, registering 264 yards and four touchdowns on 78 carries (3.4 YPC).

  • West Virginia’s offense has been subpar this season, ranking 104th in scoring (20.5 PPG), while putting up 325.0 yards per game (108th).
  • On the defensive side, the Mountaineers are 118th this season, allowing 33.9 points per game. In terms of yardage, they’re 117th, conceding 442.1 yards per contest.

Colorado vs. West Virginia Pick

Spread Pick for Colorado vs. West Virginia

  • Colorado Buffaloes +6.5 (-112) (5 units)

These are two of the worst teams in the Big 12, so I just can’t justify laying nearly a touchdown’s worth of points in a battle of bottom feeders. I’m taking the points with the Buffs in this one.

Really, from a statistical standpoint, my biggest issue with West Virginia is its pass defense. The Mountaineers are allowing 278.1 passing yards per game, which is 128th in the nation. Opposing quarterbacks are completing 66.4% of their passes against them (107th). Colorado’s offense should be able to pass the ball at will in this game, and that’s going to be their path to covering the spread in this one. Heck, they may even win outright against this lowly West Virginia team. Give me Colorado.

Over/Under Pick for Colorado vs. West Virginia 

  • Under 53.5 (-105) (5 units)

I am going to play the under in this game. Both teams are rolling out depth quarterbacks, and for as bad as these defenses are, perhaps they’ll be able to confuse the opposing inexperienced quarterbacks. Plus, the Mountaineers should be able to lean on the run game quite a bit. They’re taking on a Buffs side that’s 130th in rushing yards allowed per game (215.9). This should keep the clock churning.

From a trends perspective, the under is 4-1 in West Virginia’s last five home games, as well as 8-4 in Colorado’s last 12 overall. Let’s take the under.

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