Eastern Kentucky vs Jacksonville State Picks and Prediction for Saturday September 5 2026
Eastern Kentucky travels to Jacksonville, Alabama, to face Jacksonville State on Saturday, September 5. Both teams enter at 0-1, making this an immediate opportunity to rebound from opening-week defeats. Jacksonville State is currently favored by 20.5 points, while the total is set at 54.5. Get into the action with our free college football picks.
Eastern Kentucky Gets Three Scores
Eastern Kentucky has already played, but the Colonels now step up against an FBS opponent.
Getting 20.5 gives them almost three touchdowns of protection.
Their challenge is preventing Jacksonville State from using its depth advantage to create separation late in the game.
Jacksonville State Needs a Response
Jacksonville State also enters 0-1, so there should be little concern about the favorite overlooking its opponent.
The Gamecocks should be motivated to establish control early and avoid beginning the season with consecutive defeats.
The market reflects the talent advantage by making Jacksonville State roughly a three-touchdown favorite.
Eastern Kentucky vs Jacksonville State Picks and Prediction
Pick: Eastern Kentucky +20.5
I'm taking Eastern Kentucky +20.5. Jacksonville State should rebound and win, but almost three touchdowns gives the Colonels useful protection. A Jacksonville State 34, Eastern Kentucky 17 final produces a comfortable favorite victory while cashing the dog.
Pick: Under 54.5
I'll also take Under 54.5. Eastern Kentucky may have difficulty contributing enough offense to force the game into the upper 50s. Jacksonville State doesn't need to score 40-plus to win comfortably.
Final Picks: Eastern Kentucky +20.5 and Under 54.5