Florida State vs Louisville Picks and Prediction for Friday October 9, 2026
The Florida State Seminoles will be on the road Friday night for an ACC matchup in Louisville, Kentucky, against the Louisville Cardinals. Kickoff is scheduled for 7 PM with coverage on ESPN. Florida State comes into this game 3-2 overall and 1-1 in conference play following a convincing win over Virginia last weekend. The Seminoles will look to build on that victory as they continue their ACC schedule. Louisville will welcome the home crowd Friday night with a 2-3 overall record and a 1-2 mark in conference play. The Cardinals have lost two straight conference games and will look to get back in the win column against Florida State. Louisville is listed as a 3.5-point favorite, with the total set at 59.5 points. The Cardinals are -180 on the money line, while Florida State comes in at +150. Stay in the action with our College Football Picks.
Florida State looks to keep it rolling
Ashton Daniels is leading the Florida State offense through their first 5 games of the season with 1111 yards and 6 touchdowns on 70 completions, along with 278 yards and 9 scores on 57 carries. Ousmane Kromah is the top ball carrier on the roster with 477 yards and five touchdowns on 81 carries this season. Duce Robinson has bolstered a team with 280 yards and two touchdowns on 15 receptions. Jayvan Boggs has added 257 yards and 1 score on 13 carries, and Samuel Singleton Jr. has chipped in 162 yards and two touchdowns on 8 receptions.
Florida State was a better team a week ago in their matchup with Virginia, compiling 464 yards to score 38 points in the game. Defensively, Florida State was phenomenal, giving up 7 points on 205 yards and allowing no points across the final 3 quarters. Ashton Daniels carried Florida State a week ago, completing 12 passes for 183 yards and running the ball 17 times for 136 yards and five scores. Ousman Kromah added 80 yards on 17 carries. Micahi Danzy led the team with 70 yards on 4 receptions.
Louisville tries to defend home field
Lincoln Kienholz is leading the Louisville offense this season with 1394 yards and 9 touchdowns on 96 completions, along with 158 yards and six scores on 52 carries. Keyjuan Brown is the top ball carrier on the team with 367 yards and three scores on 38 carries, while Isaac brown has added 57 carries for 322 yards and 2 scores. Tre Richardson leads the team with 445 yards and two touchdowns on 28 receptions.
Offensively, Louisville moved the ball well a week ago, scoring 28 points on 485 total yards but turned the ball over 3 times in the loss. Defensively, Louisville was horrendous, giving up 31 points on 493 yards in the game. Lincoln Kienholz led the way for the Louisville offense last week with 254 yards and two touchdowns on 21 completions. Isaac brown led the team with 125 yards and one score on 9 carries, and Keyjuan Brown added 88 yards and 1 score on 8 carries. Tre Richardson led the team with 117 yards and 1 touchdown on 8 receptions.
Florida State vs Louisville Picks and Prediction
Pick: Louisville Cardinals -3.5 (-112)
Louisville should have the upper hand Friday night when Florida State comes to town. The Cardinals have an opportunity to take advantage of a Seminoles team that has struggled to find consistency, especially when things aren't going their way. Louisville has enough talent offensively to move the ball and keep pressure on Florida State need to avoid mistakes and find ways to finish drives with points. Playing on the road against a conference opponent is never easy, and Louisville should be able to take advantage of its home field. The Cardinals have a good opportunity to control this matchup and come away with a win.
Pick: Over 59.5 (-112)
Friday's matchup between Florida State and Louisville has the potential to produce plenty of points. Louisville should be able to move the football at home, while Florida State has enough offensive talent to answer with scoring drives of its own. Neither team can afford to give up explosive plays, but both offenses have opportunities to create problems for the opposing defense. If Florida State falls behind early, the Seminoles could find themselves throwing the football more often, which would create additional scoring chances. This game could turn into a back-and-forth battle with both teams finding the end zone several times. Look for the offenses to have success and the final score to finish above the posted total.