Illinois vs. Indiana Prediction and Picks - September 20, 2025
Illinois vs. Indiana Prediction and Picks - September 20, 2025
Illinois is traveling to Indiana University Memorial Stadium in Bloomington, Indiana for their week four matchup against Indiana; keep reading for our Illinois versus Indiana prediction. Illinois and Indiana are both tied for third in the Big 10 with a record of 3-0. Indiana lost their last game to Illinois in 2023 with a final score of 48-45. Kickoff is scheduled for 7:30 p.m. EDT. If you are struggling to pick winners, you've come to the right place. We have the strongest NCAAF Predictions.
Illinois’ Stalwart Defending
Illinois is coming off a win last week versus Western Michigan with a final score of 38-0. This would be their third win in a row as the Fighting Illini remain undefeated so far this season. This will be the first conference game for Illinois this season.
The Fighting Illini have been one of the better defenses so far this season in points allowed, as they sit seventh overall. The key to Illinois’ defense stems from their defensive line as they rank 19th in rushing yards allowed and yards per carry at 2.7. This, in combination with their pass rush that sits 15th in sacks, and you have a team that has reliably been able to stop most offenses thrown their way. Last season, the Fighting Illini finished 32nd in the country in points allowed.
Senior Luke Altmyer will be continuing his season as the starting quarterback for Illinois.
Luke Altmyer:
- has a passer rating of 182.0 with 709 yards and 8 touchdowns in 3 games this season.
- had a passer rating of 144.0 with 2,717 yards, 22 touchdowns and 6 interceptions in 13 games in 2024.
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Indiana Dominating The Run
Indiana picked up another win last week against Indiana State with a final score of 73-0. This is the third win in a row for the Hoosiers and they also remain undefeated this season. This will be the first conference game for Indiana this season.
The Hoosiers have kicked off their season with an impressive offense, much like last season. Last season, Indiana finished fourth overall in points and 30th in passing yards. This season, the Hoosiers are 29th in passing yards and fifth in points. We haven’t seen much change in the offensive prowess of Indiana during the offseason, and we should expect a similar team going into this season.
Junior Fernando Mendoza will be spearheading as quarterback for Indiana this season.
Fernando Mendoza:
- has a passer rating of 189.7 with 708 yards and 9 touchdowns in three games this season.
- had a passer rating of 144.6 with 3,004 yards, 16 touchdowns, and six interceptions in 11 games in 2024 with California.
Illinois vs. Indiana Prediction and Picks
Spread Pick for Illinois vs. Indiana
- Illinois +5.5 (-105) (4 units)
Indiana had a record against the spread last season of 0-2-0 against ranked opponents. As a road underdog last season, Illinois had a record against the spread of 3-1-0. In the last meeting between these two schools at Indiana, Indiana picked up the win but only narrowly in a 23-20 victory. Indiana may have an impressive pass game, but the Fighting Illini’s pass rush has been hard to get around so far this season, and as a result, I believe we will have a close game with neither defense allowing much.
Over/Under Pick for Illinois vs. Indiana
- Under 52.5 (-110) (4 units)
Illinois had an over/under record of 1-5-0 last season when facing off against ranked opponents. Both these schools have been hard to score points against. While both teams have a reliable offense and quarterback, I do not believe those will be the difference makers in this matchup, but rather the defenses. This will be a low-scoring game against two of the top teams in the country.
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