Indiana Hoosiers vs Maryland Terrapins Prediction and Picks - November 1, 2025

By: Dean Whitaker Published 10/30/2025, 06:35 PM ET
Malik Washington looks to lead the Terps over the Hoosiers
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Saturday afternoon College Football action within the Big 10, and we have an Indiana vs Maryland Prediction locked and loaded for you. The Hoosiers come in ranked 2nd in the nation at 8-0, and they are off a 56-6 home win over UCLA. Maryland comes in off a 20-17 loss at UCLA two weeks ago, to fall to 4-3 on the year. Is Indiana the best team in the nation? Can Maryland keep this one close or pull the outright upset? Read on to see our Indiana vs Maryland prediction.

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Hoosiers Are Most Complete Team In The Nation

Indiana comes into this matchup looking every bit the part of a national title contender. Sitting at 8-0 and ranked No. 2 in the country, the Hoosiers are fresh off a 56-6 demolition of UCLA that showed just how complete this team is right now. The defense set the tone immediately with a pick-six from linebacker Aiden Fisher, and quarterback Fernando Mendoza once again looked sharp, throwing three touchdown passes and adding a rushing score before exiting late in the third quarter. Running back Roman Hemby chipped in with 81 yards and two touchdowns on the ground, while wideout E.J. Williams Jr. torched the Bruins for 109 yards and two scores. It was the kind of performance that reinforced Indiana’s balance and depth on both sides of the ball.

Offensively, the Hoosiers have been nearly unstoppable. Mendoza has been efficient and explosive, completing nearly 73 percent of his passes with 24 touchdowns against just three interceptions on the season. He’s also added three rushing scores, giving defenses headaches with his ability to extend plays. Hemby has been steady as the lead back, averaging almost five yards per carry, while Omar Cooper Jr. and Elijah Sarratt have been reliable targets alongside Williams. Indiana is averaging 45.4 points per game, good for third nationally, and they’ve shown they can score in bunches whether through the air or on the ground.

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Defensively, Indiana has been just as dominant. The Hoosiers are allowing only 10.9 points per game, ranking third in the nation, and they’ve been particularly stingy against the run, giving up just 85 yards per contest. The pass rush has been relentless, with Rolijah Hardy and Isaiah Jones combining for double-digit sacks, while the secondary has been opportunistic with multiple interceptions from Louis Moore. This is a unit that thrives on pressure and discipline, and against a Maryland offense that has struggled to finish drives, Indiana will look to suffocate the Terps early and force them into uncomfortable passing situations.

Maryland Falls Short Against UCLA

Maryland enters at 4-3 overall and 1-3 in the Big Ten, but the Terrapins have been more competitive than their record suggests. Their most recent outing was a 20-17 loss to UCLA, a game that slipped away late on a last-second field goal. Quarterback Malik Washington threw for 210 yards and a touchdown while also rushing for 67 yards, showing his dual-threat ability. Running back DeJuan Williams was active both on the ground and through the air, finishing with 133 total yards, while Shaleak Knotts added 54 receiving yards on three catches. The Terps moved the ball but couldn’t capitalize enough in scoring situations, and that’s been a recurring theme this season.

Offensively, Maryland has leaned heavily on Washington, who has thrown for over 1,700 yards with 11 touchdowns while also contributing three rushing scores. He’s been streaky at times, but his ability to extend plays and create with his legs gives the Terrapins a fighting chance against stronger opponents. Williams has been the lead back, though the run game has been inconsistent, averaging just over 100 yards per game. Knotts has been the most reliable receiver, already with five touchdown grabs, while Octavian Smith Jr. has provided another steady option. The challenge for Maryland has been sustaining drives against top-tier defenses, and that will be tested again against Indiana’s elite front seven.

Defensively, the Terrapins have been better than their offensive numbers suggest. They’re allowing just 17.3 points per game, ranking inside the top 20 nationally, and they’ve been excellent at generating pressure, sitting ninth in the country in sacks. Linebacker Daniel Wingate has been the anchor with over 60 tackles, while defensive linemen Sidney Stewart and Zahir Mathis have combined for double-digit sacks. The secondary has also been opportunistic, with Jalen Huskey recording three interceptions. Maryland’s defense has kept them in games, but the question is whether they can hold up for four quarters against an Indiana offense that rarely takes its foot off the gas.

Indiana vs Maryland Pick

Indiana vs Maryland Spread Pick

  • Indiana -21.5 (5 Units)

Indiana -21.5 looks like the right side because the Hoosiers have been steamrolling opponents with a mix of offensive firepower and defensive dominance. Fernando Mendoza has been in complete command of the offense, spreading the ball around to multiple playmakers while Roman Hemby keeps defenses honest on the ground. They’re averaging over 45 points per game and have shown no hesitation in putting teams away early, which matters when you’re laying a big number. Against a Maryland team that has struggled to finish drives and protect the football, Indiana’s balance and efficiency should create separation quickly.

On the other side, Indiana’s defense has been just as impressive, holding opponents under 11 points per game and thriving on turnovers. Maryland’s Malik Washington has flashed playmaking ability, but he’s also been inconsistent, and facing this Hoosiers front seven is a tall order. Indiana’s ability to control both lines of scrimmage means Maryland will likely be playing from behind, which only increases the chances of mistakes and short fields for the Hoosiers’ offense. With their current form and motivation, Indiana has all the tools to cover a three-touchdown spread on the road.

Indiana vs Maryland Over/Under Pick

  • Over 50.5 (4 Units)

The over 50.5 looks like a strong angle because Indiana’s offense has been relentless, averaging more than 45 points per game, and they’ve shown no hesitation in running up the score once they get rolling. Maryland, while inconsistent, has enough playmaking ability with Malik Washington’s dual-threat skills and DeJuan Williams out of the backfield to contribute their share, especially in garbage-time situations if the Hoosiers build a big lead. With Indiana’s explosive passing attack and Maryland’s tendency to give up chunk plays but also sneak in points late, this matchup has all the ingredients for a game that pushes past the number.

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