Iowa State Cyclones vs. Cincinnati Bearcats Picks and Predictions, Saturday October 4, 2025

By: Nathan Smith Published 10/02/2025, 06:23 PM ET
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The 2025 College Football season is heating up in a big way, and with the pressures of every game mounting, we'll see two fantastic teams do battle on Saturday with our Iowa State Cyclones vs. Cincinnati Bearcats prediction.

The 14 Iowa State Cyclones (5-0) have been off to a dominant start in 2025, and with the team continuing to climb the rankings, a notable road win in this matchup could do them wonders as they target a place in College Football's top 10 teams.

On Saturday, they take on the Cincinnati Bearcats (3-1), a team that has bounced back to win three straight after an opening night loss, and now, they aim to cause the biggest upset of their season as they look to continue their impressive momentum. Read on to see our Iowa State Cyclones vs. Cincinnati Bearcats prediction.

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Can Iowa State continue their unbeaten start to the year?

The 14 Iowa State Cyclones have played just one game on the road this season, but with a 5-0 start, including a 1-0 record on the road and a 1-0 record against ranked opponents, people around college football are starting to take notice of this team. Offensively, the Cyclones rely heavily on their efficiency, with the team ranking top-30 in the nation in yards per attempt, completion percentage and QB rating, and with the team allowing just 309 yards of offense a game, when they're at their best, they're an incredibly balanced squad.

Under center, the Cyclones have gotten fantastic production from junior QB Rocco Becht, who has a 7/2 TD/INT ratio on the season thus far, and with five extra scores on the ground, this balanced attack can beat anyone in college football. Becht also has thrown for 1,103 yards and tossed for 240 yards in their win over Arizona last week. Last time out for Iowa State was a dominant home win over Arizona, with the team rushing for five touchdowns on the day as they limited their opponents to 360 total yards, winning 39-14 on the back of two massive turnovers. East Carolina transfer wide receiver Chase Sowell had a career-high 146 against the Wildcats.

Can Cincinnati pick up a massive upset win?

The Cincinnati Bearcats lost in their first game of the season, but since then, they've gone a perfect 3-0, with the offense blossoming into one of the best in all of college football during that span, with their most dominant victory of the year thus far coming at home. For Cincinnati, this success comes completely on the back of their offense, one that now ranks third in the nation in yards per play while being top-20 in total yards per game, rushing yards per play, as well as coming in seventh in quarterback rating this season.

That play at quarterback comes from Brendan Sorsby, who has tossed an impressive 10 touchdowns this season, and with the junior leading the team with four touchdowns on the ground as well, he's blossomed into one of the most dominant players at the position in college football. Last time out for the Bearcats was a tight road win over Kansas, with 388 passing yards and 215 yards on the ground showing just how high-powered this offense is, with the defense forcing one crucial turnover as they came away winners 37-34 despite allowing 597 yards on the day. Cyrus Allen leads the way with 23 catches for 273 yards and five touchdowns.

Iowa State Cyclones vs. Cincinnati Bearcats pick

Moneyline pick for Iowa State vs. Cincinnati

  • Iowa State +1.5 (4 units)

These two teams have played once a year for the past two seasons, and in that time, it's the Cyclones that have come away with a 2-0 record, outscoring the Bearcats by an average of 18 points across those two victories.

However, Cincinnati has found its offense as of late, putting up 30 or more in each of its last three games, but with the Cyclones being so incredibly balanced and also sitting at 1-0 on the road this season, expect them to keep their unbeaten start going in this one.

Over/Under pick for Iowa State vs. Cincinnati

  • Over 55.5 (4 units)

Both of these teams have shown their defensive potential in 2025, but for the most part, they both rely on their offenses to get the job done, as they both put up over 35 points a week ago in crucial victories.

For the Cyclones, the over sits at 3-2 in five games this season, with 32 points a game scored this season, and for the Bearcats, the over comes in at 3-1 this season, with all three coming in the past three games as they've averaged an impressive 47 points a game in that stretch.

Keep it simple, take the over.

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