Iowa State Cyclones vs Oklahoma State Cowboys Prediction and Picks - November 29, 2025
Use Code SSWC Saturday afternoon Big 12 College football action, and we have an Iowa State vs Oklahoma State prediction locked and loaded for you. Iowa State enters this contest off a 38-14 home win over Kansas to move to 7-4 on the year. Oklahoma State has had a miserable 1-10 season so far, and they are off a 17-14 home loss to UCF. Read on to see our Iowa State vs Oklahoma State prediction.
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Cyclones Crush Jayhawks At Home
At 7-4 overall and 4-4 in Big 12 play, Iowa State comes into the regular-season finale riding momentum from a 38-14 win over Kansas on November 22 in Ames. Quarterback Rocco Becht was sharp, throwing for 241 yards and three touchdowns, with two scores going to Brett Eskildsen. Running back Carson Hansen added 120 rushing yards and a touchdown, while tight end Benjamin Brahmer caught a 12-yard score in the third quarter. The Cyclones controlled the game from start to finish, outgaining Kansas 462-323 and dominating time of possession.
Offensively, Iowa State has been balanced all season, averaging 400.6 yards per game and 28.1 points per contest. Becht has thrown for 2,471 yards and 15 touchdowns, while Hansen leads the ground game with 841 rushing yards and six scores. Abu Sama III has chipped in 645 rushing yards, giving the Cyclones a reliable one-two punch in the backfield. Eskildsen has emerged as the top receiver with 507 yards and five touchdowns, while Brahmer adds 422 yards and six scores at tight end. Iowa State’s ability to spread the ball around has made them difficult to defend, and their offensive line has provided steady protection.
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Defensively, the Cyclones have been one of the stronger units in the Big 12, allowing just 20.8 points per game and 368.1 yards per outing. Their run defense has been solid, giving up 148 yards per game, while the secondary has held opponents to 220 passing yards per contest. Iowa State has forced 17 turnovers, and their ability to get stops in key moments has been a difference-maker. Heading into Stillwater, the Cyclones will look to continue their defensive consistency while leaning on Becht and Hansen to control tempo and secure their eighth win of the season.
It's Finally Over For The Cowboys
Oklahoma State sits at 1-10 overall and 0-8 in Big 12 play, coming off a 17-14 road loss to UCF on November 22. The Cowboys led 14-0 at halftime behind touchdowns from quarterback Zane Flores and receiver Gavin Freeman, but the offense stalled in the second half. UCF rallied with two Dylan Wade touchdown catches and a late field goal to steal the win. Oklahoma State managed just 22 yards after halftime, punting five times and throwing a costly interception in the final minute.
Offensively, the Cowboys have struggled all season, averaging only 14.3 points per game, ranking near the bottom nationally. Flores has thrown for 1,288 yards and five touchdowns, but turnovers have been an issue with six interceptions. Running back Rodney Fields Jr. has been the most consistent weapon, rushing for 614 yards, while Freeman leads the receiving corps with 435 yards and four scores. Despite flashes of promise, Oklahoma State has lacked rhythm and efficiency, often failing to sustain drives.
Defensively, the Cowboys have allowed 34.5 points per game and nearly 425 yards per outing, making it difficult to stay competitive. Their run defense has given up 160 yards per game, while the secondary has surrendered 265 passing yards per contest. Oklahoma State has forced just 15 turnovers, and their inability to close out games has been a recurring theme. Facing Iowa State’s balanced attack, the Cowboys will need their defense to step up while hoping Flores and Fields can generate enough offense to keep things close.
Iowa State vs Oklahoma State Pick
Iowa State vs Oklahoma State Spread Pick
- Iowa State -13.5 (4 Units)
Taking Iowa State at -13.5 makes sense given the clear gap between these two teams right now. The Cyclones are averaging over 400 yards of offense per game and nearly 28 points per contest, with quarterback Rocco Becht throwing for more than 2,400 yards and 15 touchdowns. Their rushing attack, led by Carson Hansen and Abu Sama III, has combined for nearly 1,500 yards, giving them balance and control at the line of scrimmage. Against an Oklahoma State defense that’s surrendering 34.5 points per game and over 425 yards per outing, Iowa State’s ability to sustain drives and finish in the red zone should allow them to build a comfortable margin.
On the other side, Oklahoma State has been one of the least productive offenses in the country, averaging just 14.3 points per game and under 300 yards of total offense. Quarterback Zane Flores has thrown for 1,288 yards but with only five touchdowns and six interceptions, while the ground game has been inconsistent outside of Rodney Fields Jr.’s 614 rushing yards. That lack of firepower makes it difficult to envision the Cowboys keeping pace with Iowa State’s balanced attack. With the Cyclones also boasting a defense that allows just 20.8 points per game, the matchup tilts heavily in their favor, and laying the 13.5 looks like the right side.
Iowa State vs Oklahoma State Over/Under Pick
- Under 46 (5 Units)
The Under 46 feels like the right call because Iowa State’s defense has been one of the most reliable in the Big 12, holding opponents to just 20.8 points per game, while Oklahoma State’s offense has been among the least productive in the nation at only 14.3 points per contest. The Cowboys have struggled to sustain drives, averaging under 300 total yards per game, and Iowa State’s balanced attack tends to control tempo rather than push games into shootouts. With the Cyclones capable of limiting Oklahoma State’s scoring opportunities and the Cowboys unlikely to generate much offensive rhythm, this matchup sets up well for a lower-scoring outcome that stays beneath 46.
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