Kansas vs. Arizona, Picks, Preview, Prediction and Picks for Saturday, November 8th, 2025

By: Trenton Pruitt Published 11/06/2025, 08:44 PM ET
Kansas vs. Arizona Prediction
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A couple of mid-tier Big 12 schools will get together this weekend, and this should be a fun matchup between the Kansas Jayhawks (5-4, 3-3 B12) and the Arizona Wildcats (5-3, 2-3 B12). We’ve got you covered with our Kansas vs. Arizona prediction. Kickoff is scheduled for 3:30 ET from Arizona Stadium in Tucson, AZ. Don’t get sacked this football season! Try our College Football Picks!

Jayhawks Bounce Back, Beat Cowboys

This is the fifth season that Coach Lance Leipold has been in charge of the Kansas Jayhawks, and he has posted an underwhelming 27-32 (16-26 B12) record thus far. That includes this year’s 5-4 (3-3 B12) mark. Kansas doesn’t really have a notable win, as the Jayhawks have picked off bottom feeders like West Virginia (41-10), UCF (27-20), and Oklahoma State (38-21), most recently. As for their sports betting numbers, Kansas is 3-6 ATS and 5-4 to the over.

Veteran QB Jalon Daniels is back under center this season, and he has looked impressive. The senior has thrown for 1,991 yards on a 66.7% completion rate, adding 20 touchdowns and three interceptions. WR Emmanuel Henderson Jr. is his top target, hauling in 36 passes for 573 yards and four touchdowns. RB Leshon Williams has spearheaded the rushing attack, gaining 391 yards and six touchdowns on 71 carries (5.5 YPC).

  • Kansas’ offense has been decent this season, ranking 49th in scoring (29.5 PPG), while putting up 361.3 yards per game (79th).
  • On the defensive side, the Jayhawks are 80th this season, allowing 27.6 points per game. In terms of yardage, they’re 100th, conceding 413.1 yards per contest.

Wildcats Decimate Buffs in Boulder

Coach Brent Brennan is now in his second season in Tucson, and his Arizona Wildcats are emerging as a mid-tier team in the Big 12. They enter the weekend at 5-3, sporting an 11th-place record of 2-3 in the conference. Arizona had recently dropped back-to-back games to #18 BYU (33-27) and Houston (41-28), but they bounced back by hammering Colorado 52-17 last time out. The Wildcats have gone 5-3 ATS and split their totals 4-4 to the over/under.

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QB Noah Fifita continues to be a serviceable option at quarterback in Tucson, and he’s putting together another solid season. The signal caller has thrown for 2,042 yards on a 65.4% completion rate, adding 21 touchdowns and four picks. WRs Javin Whatley (404 yards, 4 TD) and Kris Hutson (355 yards, 3 TD) lead the way out wide. RB Ismail Mahdi has picked up 530 yards and two touchdowns on 80 totes (6.6 YPC).

  • Offensively, the Wildcats are scoring 32.1 points per game (31st), while averaging 396.4 yards per week (54th).
  • Defensively, they are 34th in the country this year, conceding 22.3 points per game. They’re allowing 309.3 yards per contest, which is 16th.

Kansas vs. Arizona Pick

Spread Pick for Kansas vs. Arizona

  • Arizona Wildcats -5.0 (-110) (5 units)

Even though neither of these teams is competing for a conference title, this should still be an electric matchup between two top-tier quarterbacks. However, I really just have one gripe with Kansas, and it’s that they fail to win every time they step up in competition. The Jayhawks are 5-4, but their wins are against Fresno St., Wagner, West Virginia, UCF, and Oklahoma State. They haven’t beaten one notable opponent this year.

The defense appears to be the big issue for me as well, as Kansas has allowed 37+ points in all four of its losses. That’s not a great recipe when heading on the road to take on Noah Fifita and a solid Arizona offense. I think it’ll be a decent game, but until I see Kansas prove that it can beat an opponent of equal or greater value, then I’m going to continue betting against them. I’ll take the Wildcats to win by 7+ points.

Over/Under Pick for Kansas vs. Arizona 

  • Over 56.5 (-105) (5 units)

This is one of those games where I’m going to kick my feet up and watch two veteran, explosive quarterbacks go to work. Noah Fifita enters with a 21/4 TD/INT ratio, while Jalon Daniels has a 20/3 ratio. As I mentioned above, Kansas’ defense has faltered when stepping up in competition, so I’m expecting Fifita & Co. to feast in this one. Both teams have been profitable to the over recently, each going 4-1 to the over in their last five games. It’s a lofty total, but I think it’s best to side with the over.

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