LSU vs Kentucky Picks and Prediction for Saturday October 10, 2026
The LSU Tigers will travel to Lexington, Kentucky, Saturday night for an SEC matchup against the Kentucky Wildcats. Kickoff is scheduled for 7 PM with television coverage on ESPN. LSU enters the weekend ranked No. 10 nationally and will look to continue its pursuit of an SEC championship. The Tigers have another opportunity to improve their conference standing but will need to handle a difficult road environment. Kentucky will welcome LSU to Kroger Field, looking to pick up a significant victory against a nationally ranked opponent. The Wildcats will attempt to use their home-field advantage to challenge the Tigers and get back on track in conference play. LSU is listed as a 9.5-point favorite, with the total set at 50.5 points. The Tigers are -345 on the money line, while Kentucky comes in at +275. Stay in the groove with our College Football Picks.
LSU looks for the conference road win
Sam Leavitt leads the LSU offense this season with 1,221 passing yards and eight touchdowns on 92 completions, along with 220 rushing yards and six touchdowns on 45 carries. Dilin Jones leads the Tigers rushing attack with 426 yards and five touchdowns on 94 carries. Harlem Berry has added 196 yards and one touchdown on 27 carries, while Stacy Gage has chipped in 166 yards and two scores on 21 carries. Winston Watkins Jr. leads all LSU receivers with 354 yards and two touchdowns on 23 catches. Jackson Harris has added 317 yards and two touchdowns on 15 receptions, while Trey'Dez Green has contributed 222 yards and one score on 14 catches.
LSU dominated last week, scoring 63 points on 731 total yards. Defensively, LSU was just as stout, giving up fourteen points on 196 total yards. Sam Leavitt led the show for the LSU offense a week ago, completing 18 passes for 177 yards and three scores in the game. Landen Clark added seven completions for 126 yards, and Husan Longstreet chipped in six completions for 62 yards. Harlem Berry led the team with 125 yards and one touchdown on 15 carries. Stacy Gage added six carries for 110 yards and two scores. Corey Barber Jr. led the team with 83 yards and two touchdowns on 7 receptions.
Kentucky goes for 4 in a row
Kenny Mincey leads the Kentucky offense this season with 1,148 passing yards and 11 touchdowns on 97 completions. CJ Baxter leads the Wildcats rushing attack with 361 yards and six touchdowns on 68 carries. Jason Patterson has added 355 yards and three touchdowns on 45 carries, while Jovantae Barnes has chipped in 126 yards and one score on 20 carries. Kenny Darby leads all Kentucky receivers with 322 yards and three touchdowns on 25 catches. Willie Rodriguez has added 194 yards and one touchdown on 22 grabs.
The Kentucky Wildcats did just enough a week ago, scoring 35 points, including eight in overtime on 394 total yards. Defensively, Kentucky did have their issues, giving up 34 points on 458 yards and just 7 points in overtime to seal the victory. Kenny Mincey led the show for the Kentucky offense a week ago, completing 28 passes for 272 yards and three scores. CJ Baxter led the way on the ground for Kentucky with 48 yards and one touchdown on 13 carries. Kenny Darby led the team with 96 yards and one touchdown on 12 catches, and Nic Anderson added 80 yards and one touchdown on five catches.
LSU vs Kentucky Picks and Prediction
Pick: LSU Tigers -9.5 (-108)
LSU has the talent to take control Saturday night when the Tigers visit Kentucky for an important SEC matchup. The Wildcats will have the advantage of playing at home and should be motivated to pull off an upset against a top-10 opponent. Kentucky will need to establish its offense early and avoid falling behind against a talented LSU team. The Tigers should be able to find success moving the football and create scoring opportunities throughout the game. LSU will also need its defense to make plays and keep Kentucky from extending drives. The Wildcats could keep things interesting for a while, but LSU has enough talent on both sides of the football to pull away and secure the road victory.
Pick: Over 50.5 (-118)
Points could come at a steady pace Saturday night when LSU and Kentucky meet in Lexington. The Tigers have enough offensive weapons to create problems for the Kentucky defense, especially if they establish their passing game early. Kentucky will need to answer offensively and should be willing to take chances to keep pace with LSU. The Wildcats could find success against the Tigers if they protect the football and take advantage of scoring opportunities. LSU should be able to put together several productive drives, while Kentucky could contribute enough points to keep the total moving. Look for the Tigers to lead the way offensively in a game that finishes above the posted number.