Miami-Oh RedHawks vs Buffalo Bulls Prediction and Picks - November 19, 2025

By: Dean Whitaker Published 11/18/2025, 03:31 PM ET
Ta'Quan Roberson looks to lead the Bulls over the RedHawks
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Wednesday evening MAC-tion, and we have a Miami-Oh vs Buffalo prediction locked and loaded for you. The Redhawks enter this contest at 5-5 on the year and off a 24-3 home loss to Toledo. The Bulls come in off a 38-19 road loss to Central Michigan, which puts them at 5-5 on the year. The Home team has won the last seven games in this series. Read on to see our Miami-Oh vs Buffalo prediction.

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Offense Struggles In Loss To Toledo

Miami (OH) comes into this matchup after a rough 24-3 loss to Toledo, where Henry Hesson got the start and struggled mightily. He completed just 11 of 38 passes for 147 yards with three interceptions, and the RedHawks never managed to find the end zone. The offense was bottled up throughout, with running back Jordan Brunson limited on the ground and wideout Kenny Perry held without his usual explosive plays. Miami’s lone points came on a field goal, and the defeat underscored the team’s offensive inconsistency when they can’t establish rhythm through the air.

On the season, Hesson has thrown for 489 yards with three touchdowns and six interceptions, while dual-threat quarterback Dequan Finn remains their more productive option overall but did not feature in the Toledo game. Perry continues to be the focal point of the passing attack, with 726 yards and four touchdowns at an eye-popping 25 yards per catch. Cade Weaver adds reliability underneath with 386 yards on 30 receptions, while Brunson leads the rushing attack with 488 yards on 111 carries. Defensively, Miami has been much stronger, ranking 32nd nationally in total yards allowed (326.3 per game) and forcing 12 turnovers. Their ability to hold opponents to just 21.9 points per game has kept them competitive even when the offense stalls.

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For Miami to bounce back against Buffalo, they must protect the football and lean on Perry to generate chunk plays downfield. Establishing Brunson on the ground will be critical to avoid becoming one-dimensional, especially against a Bulls defense that has been steady against the run. The RedHawks’ defense will again be asked to carry the load, and if they can force Roberson into mistakes, Miami has a path to keep this game close despite their offensive struggles

Bulls Fold In 2nd Half Vs Chippewas

Buffalo comes into this matchup off a 38-19 loss at Central Michigan, where the offense showed flashes but couldn’t overcome turnovers and defensive breakdowns. Quarterback Tyler Roberson finished 16-of-33 for 208 yards with one touchdown and one interception, but his struggles on the ground (10 carries for -13 yards) highlighted the pressure he faced all afternoon. The rushing attack leaned on Taj Shelton Jr., who posted 59 yards on 11 carries, while Victor Snow added a 44-yard burst on a gadget play. The passing game was more productive, with Nick McMillan hauling in seven catches for 122 yards and two touchdowns, and Jalen Gathings contributing six receptions for 85 yards. Despite those efforts, Buffalo was outscored 24-9 in the second half as the Chippewas pulled away.

On the season, Roberson has thrown for 1,947 yards and 13 touchdowns, though his nine interceptions remain a concern. Henderson, normally the workhorse, was limited to just 39 yards on nine carries against CMU but still leads the team with 702 rushing yards and five scores. Snow has been a versatile weapon, adding 622 receiving yards and seven touchdowns to go with his occasional rushing contributions. McMillan continues to be the most consistent target, now up to 712 yards and three scores, giving Buffalo one of the MAC’s most dangerous receiving tandems. The Bulls average 361 total yards per game, but their 18 turnovers have been a glaring issue, often undoing otherwise productive offensive stretches.

Defensively, Buffalo has been solid overall, ranking 33rd nationally in total yards allowed (327 per game) and holding opponents to just 190.5 passing yards. Their run defense has been steady at 136.5 yards allowed per contest, but the lack of takeaways — only six all season — has limited their ability to flip momentum. Against Miami, the Bulls will need to keep Henry Hesson contained and force the RedHawks to sustain long drives. If Roberson avoids mistakes and McMillan continues to produce at a high level, Buffalo has the balance to control tempo. But after the setback at Central Michigan, ball security and red-zone execution will be the deciding factors in whether the Bulls can bounce back.

Miami-Oh vs Buffalo Pick

Miami-Oh vs Buffalo Spread Pick

  • Miami -1.5 (2 Units)

Miami -1.5 makes sense given how their defense has consistently kept them in games, even when the offense sputters. Despite the ugly 24-3 loss to Toledo, the RedHawks still rank top-40 nationally in points allowed (21.9 per game) and have forced 12 turnovers on the season. That kind of defensive stability matches up well against a Buffalo team that has been plagued by giveaways, coughing it up 18 times already. If Miami can pressure Tyler Roberson into mistakes and limit Al-Jay Henderson’s impact on the ground, they’ll tilt the field in their favor and give Henry Hesson shorter, manageable drives to work with.

Buffalo’s offense has weapons, but their inconsistency and turnover issues make them vulnerable in a tight spread. Miami doesn’t need explosive scoring to cover here — they need efficiency, ball security, and a couple of big plays from Kenny Perry downfield to stretch the defense. With the RedHawks’ ability to control tempo through Jordan Brunson’s rushing and their defense’s knack for timely stops, Miami is positioned to grind out a close but controlled win. That combination of defensive reliability and Buffalo’s turnover-prone offense makes laying the small number with Miami -1.5 a logical play.

Miami-Oh vs Buffalo Over/Under Pick

  • Under 39.5 (3 Units)

The Under 39.5 feels like the right angle because both offenses have struggled with consistency and turnovers, while their defenses have been the steadier units. Miami is coming off a 24-3 loss where Henry Hesson threw three interceptions and the RedHawks managed just a field goal, highlighting their inability to finish drives. Buffalo, meanwhile, has averaged only 24.2 points per game and just put up 19 against Central Michigan despite solid production from Nick McMillan. With Miami’s defense ranking top-40 nationally in points allowed and Buffalo’s unit holding opponents under 22 per game, this matchup sets up as a grind where mistakes and field position dictate the pace, making a low-scoring outcome very realistic.

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