Missouri vs. Oklahoma, Picks, Prediction, Preview and Odds, Saturday, Nov. 22, 2025
Use Code SSWC We have a former Big 12, now SEC matchup featuring two good teams from Norman in this Missouri vs. Oklahoma prediction. Mizzou is 7-3 overall and 3-3 in the SEC is ranked 22nd in the country. OU is 8-2 overall and 4-2 in the SEC with a long shot to make their first CFP appearance since 2019. They will need to beat both Tigers (Mizzou and LSU) to have a chance at the final 12. These teams match up on a Saturday at noon. Last year, the Tigers were victorious 30-23 at home as a 3.5-point dog. Check out more big college football and NFL games this weekend on Stat Salt.
Quick Picks and Prediction on Missouri vs. Oklahoma
We have your pick, the total and analysis down below with betting odds and key injuries. If you just want the pick and score, we have it here.
- Oklahoma 28-24
- Missouri +6.5
- Over 43.5
Missouri vs. Oklahoma Odds and Line Movement
Check below for the money line, spread, and total along with the line movements for Missouri vs. Oklahoma.
Opening Odds for Missouri vs. Oklahoma
- Missouri +9.5 (-105)/Oklahoma -9.5 (-115)
- ML: Missouri +310/Oklahoma -400
- Total: 043.5 (-110)/u43.5 (-110)
(odds from FanDuel)
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Missouri vs. Oklahoma Line Movement
- Missouri +9.5 (-105)/Oklahoma -9.5 (-115) moves to Missouri +6.5 (-110)/OU -6.5 (-110)
- ML: Missouri +310/Oklahoma -400 moves to Mizzou +198/OU -240
- Total: 043.5 (-110)/u43.5 (-110) move to o42.5 (-106)/u42.5 (-114)
Key Matchups for Missouri vs. Oklahoma
Mizzou hopes to continue to run the football
For Missouri to be successful, it needs to be able to run the football . That will be easier said than done against the nation's No .4 rush defense (82.2ypg). The Tigers average a lofty 241.7 yards per game on the ground. With starting QB Beau Pribula (dislocated ankle) still out after suffering an anjury against Vanderbilt (17-10 loss) on Oct. 25, the Tigers need a running game more than ever. They lost to Texas A&M 38-17 at home in their next game on Nov. 8, after a bye. Last week, they rebounded from a two-game losing streak to rout Mississippi State 49-27 at home as a 7-point favorite.
Though there is a reason why the line moved from Oklahoma -9.5 to -6.5. Pribula was medically cleared to play on Thursday and is considered a game-time decision. QB Matt Zoller has done a decent job filling in for Pribula, tossing for 402 yards with four TDs and one pick, but completing just 53% of his passes. Pribula offers more accuracy (69.6%), along with 1,685 passing yards (11 TDs, 7 INTs) with 220 rushing yards and five TDs. The real star on offense is RB Ahmad Hardy with 1,346 yards and 15 TDs. With an improved passing game, assuming Pribula plays, the Tigers hope they can get something going on the ground against the Sooners.
Sooners are back?
Oklahoma's win over Tennessee on the road, 33-27 on Nov. 1 opened some eyes, but that came after losses to Ole Miss at home by eight and to Texas (23-6) on the road. If you really want to open some eyes, especially those on the CFP poll, you need to beat a top 10 team. That's what the Sooners did last week when they edged then-No. 4 Alabama 23-21 on the road as a 6.5-point underdog. It's the jolt the program and it was the defense that got things done, holding the Tide to just 80 rushing yards on 33 attempts.
QB John Mateer managed the game with 138 yards passing, but the offense really never got it going as they amassed just 12 first downs and 212 yards. The defense allowed 326 passing yards, but they also picked off Ty Simpson, a potential Heisman Trophy candidate, early in the game thanks to Eli Bowen's 87-yard interception return for a touchdown. That would ultimately be the difference and it helped end Alabama's 17-game home winning streak.
The Sooners have a gutsy quarterback in Mateer, who has 2,087 passing yards, eight TDs passing and seven ITs, with 329 rushing yards and seven scores. The offense is solid, but they aren't very explosive, averaging just 28.3 points per game (64th) and 130.7 rushing yards (98th). The defense is elite and has helped them get to the point, forcing opponents to just 278.4 total yards per game (11th).
Betting Trends for Missouri vs. Oklahoma
Missouri:
- 12-5-1 ATS last 18.
- 10-5 Over last 15.
OU is:
- 6-3 ATS last 9 games.
- 9-2 Under last 11.
- 5-1 Over last 6 vs. Mizzou.
Key Injuries and Analysis for Missouri vs. Oklahoma
Missouri
- QB Beau Pribula (dislocated ankle) has missed the last two games but could play in this game.
Oklahoma
- DE R Mason Thomas (ankle) is questionable. Missed the Alabama game. Has 6.5 sacks and was injured on a fumble return against Tennessee.
- CB Gentry Williams (undisclosed) is questionable. Has made five starts in six games.
Missouri vs. Oklahoma ATS and Over/Under Betting Picks
Read on for more on why I like the spread and title, with analysis on both using logic and stats.
Missouri vs. Oklahoma Spread
- Missouri +6.5 (4 units)
Total for Missouri vs. Oklahoma
- Over 43.5 (4 units)
Mizzou vs. Oklahoma Final Score Prediction
- Oklahoma 28-Missouri 24
Yes, I think this will be a higher-scoring game than expected. As good as Oklahoma is, when you beat Alabama on the road, there has to be some sort of emotional letdown. Mizzoui put up 24 points against Alabama at home (lost by 3), 23 against Auburn and 29 against South Carolina with Pribula at quarterback. Without him, they scored just 17 against A&M and had 10 against Vandy when he was injured early on a 4th-and-1 play. Oklahoma's defense could also be without their best pass rusher in Thomas. The key for Mizzou is to throw the ball well enough to establish Hardy and the running game. Mateer is also do for a solid game and both of these teams are capable of putting their offenses ins great field position with turnovers. Take the over.
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