Missouri vs Ole Miss Picks and Predictions for Saturday, October 17, 2026
The No. 13 Missouri Tigers (5-1, 2-1 SEC) visit the No. 9 Ole Miss Rebels (4-1, 2-1 SEC) on Saturday at Vaught-Hemingway Stadium in Oxford, Mississippi, with the opening kickoff at 3:30 PM ET on SEC Network. Both teams are tied for fourth in the SEC standings. Missouri defeated Texas A&M 27-6 last Saturday, while Ole Miss beat Vanderbilt 52-17. The Rebels are six-point home favorites, with the total at 59.5. Cash in a winning ticket with our free NCAAF picks.
Missouri Builds on Consecutive SEC Victories
Missouri has won two straight games since suffering its only defeat, a 31-24 loss at Mississippi State on September 26. The Tigers followed that setback with a 45-17 victory over Florida before holding Texas A&M to six points last weekend. Missouri also defeated Kansas 38-21 and Troy 27-17 earlier this season. The Tigers have scored 161 points across their last five games while allowing 92, averaging 32.2 points scored and 18.4 allowed during that stretch.
Quarterback Austin Simmons has thrown for 1,434 yards, 14 touchdowns, and just one interception while completing 64.8% of his passes. Running back Jamal Roberts has rushed for 828 yards and eight touchdowns on 147 carries, averaging 5.6 yards per attempt. Cayden Lee leads the receiving attack with 616 yards and five touchdowns, while Donovan Olugbode has 407 yards and six scores. Missouri has 1,090 rushing yards and 11 rushing touchdowns. Defensively, Nicholas Rodriguez leads the Tigers with 63 tackles, Daeden Hopkins has 6.5 sacks, and Trajen Greco has two interceptions.
Injuries: D. Smith (questionable); G. Hoffman, J. Brady, C. Green, A. Hardy (out).
Ole Miss Responds With Dominant Road Victory
Ole Miss bounced back from its first loss with a 52-17 victory at Vanderbilt on October 10. The Rebels had previously suffered a 52-28 defeat at Florida on September 26, their only setback through five games. Ole Miss defeated LSU 32-24, Charlotte 41-9, and Louisville 41-38 during its first three contests. The Rebels have scored at least 28 points in every game and have averaged 38.8 points per contest. However, Ole Miss has also allowed 52 points against Florida and 38 against Louisville.
Quarterback Trinidad Chambliss has completed 70.1% of his passes for 1,435 yards, 11 touchdowns, and four interceptions. Deuce Alexander leads Ole Miss with 503 receiving yards and five touchdowns, while Traylon Ray has added 231 yards. Running back Kewan Lacy has rushed for 230 yards and five touchdowns on 46 attempts, while Chambliss has contributed another five rushing scores. The Rebels have 666 yards rushing and 12 touchdowns on the ground. Defensively, Luke Ferrelli leads Ole Miss with 34 tackles, Blake Purchase has 3.5 sacks, and Nick Cull has two interceptions.
Injuries: I. Hartrup (questionable).
Key to the Game
Missouri's rushing attack presents a significant challenge for Ole Miss, with Roberts averaging 138 rushing yards per game. The Tigers also have a quarterback who has thrown only one interception through six contests. Ole Miss counters with Chambliss, who has completed over 70% of his passes, and Alexander, who averages 100.6 receiving yards per game. Missouri has recorded 18 sacks compared with nine for Ole Miss, making pressure on Chambliss another important part of this SEC matchup.
Missouri vs Ole Miss Game Pick
- Missouri +6 (-110)
Missouri has won five of six games, including consecutive SEC victories over Florida and Texas A&M. The Tigers have allowed just 23 points across those two contests, while Simmons has thrown 14 touchdowns against one interception this season. Roberts also provides a consistent rushing attack with 828 yards and eight touchdowns. Ole Miss has scored consistently, but the Rebels surrendered 52 points at Florida and 38 against Louisville. Missouri's defensive results and balanced offensive production make the Tigers an attractive choice getting six points on Saturday.
Missouri vs Ole Miss Over/Under Pick
- Over 59.5 (-110)
Ole Miss averages 38.8 points per game and has scored at least 28 in all five contests. Missouri has averaged 32.2 points over its last five games, with Simmons throwing 14 touchdowns this season. The Rebels have allowed 52 points against Florida and 38 against Louisville, while Missouri surrendered 31 at Mississippi State. Both offenses feature productive quarterbacks and multiple scoring options. With Roberts leading Missouri's rushing attack and Chambliss directing Ole Miss, the over at 59.5 is the play for this SEC matchup.