NC State vs. Notre Dame Prediction and Picks for Saturday, October 11th, 2025

By: Trenton Pruitt Published 10/09/2025, 06:00 PM ET
NC State vs. Notre Dame Prediction
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After an ugly 0-2 start, the #16 Notre Dame Fighting Irish (3-2) have bounced back with three straight wins. They’ll host the NC State Wolfpack (4-2, 1-2 ACC) on Saturday, and they’re sizable 23.5-point home favorites against the ACC foe. We’ve got you covered with our NC State vs. Notre Dame prediction. Kickoff is scheduled for 3:30 ET from Notre Dame Stadium in Notre Dame, IN. Looking to win big this football season? We have the best College Football Picks to help you out!

Wolfpack Maul the Camels

The NC State Wolfpack are one of the few teams that has played six games thus far, and Coach Dave Doeren’s squad is off to a solid 4-2 start. That includes their 1-2 ACC record, which puts them in 11th place in the conference standings. NC State opened the year with three straight victories over East Carolina (24-17), Virginia (35-31), and Wake Forest (34-24), but then dropped consecutive outings to Duke (45-33) and Virginia Tech (23-21). They bounced back with a blowout win over FCS Campbell (56-10) last weekend. The Wolfpack are 3-3 ATS and they’ve gone 4-2 to the over.

NC State has a pretty lethal backfield, which is led by sophomore quarterback CJ Bailey. The signal caller has thrown for 1,660 yards on a 74.6% completion rate, adding 13 touchdowns and four interceptions. RB Hollywood Smothers has been a workhorse, logging 693 rushing yards and five touchdowns on 100 carries (6.9 YPC). Out wide, WR Terrell Anderson has emerged as the top target with 388 yards and three touchdowns on 21 receptions.

  • Offensively, the Wolfpack are scoring 29.4 points per game (51st), while averaging 415.8 yards per week (38th).
  • Defensively, they are 83rd in the country this year, conceding 28.0 points per game. They’re allowing 412.4 yards per contest, which is 92nd.
  • Safety Rente' Hinton (undis) is questionable.

#16 Fighting Irish Win Third Straight Game

As for the Notre Dame Fighting Irish, they got out to an ugly 0-2 start, losing on the road to #10 Miami (27-24) and at home to #16 Texas A&M (41-40). Coach Marcus Freeman and his squad have bounced back with three straight wins, hammering Purdue (56-30), Arkansas (56-13), and Boise State (28-7), most recently. Even with two losses already, the Irish are priced as a -110 coin flip to make the CFP. They don’t have a conference championship game to worry about, which you can make the case for that being an advantage in this scenario. From a game-by-game betting perspective, Notre Dame is 2-3 ATS and they’ve gone 4-1 to the over.

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Notre Dame is rolling with a freshman quarterback this season in CJ Carr. The quarterback has thrown for 1,280 yards on a 67.7% completion rate, adding 11 touchdowns and two interceptions. WR Jordan Faison is the lead receiver, hauling in 25 passes for 327 yards and two touchdowns. The two-headed rushing monster of RBs Jeremiyah Love (444 yards, 6 TD) and Jadarian Price (356 yards, 7 TD) is arguably the most lethal duo in the nation.

  • Notre Dame’s offense has been elite this season, ranking ninth in scoring (40.8 PPG), while putting up 465.0 yards per game (17th).
  • On the defensive side, the Irish are 52nd this season, allowing 23.6 points per game. In terms of yardage, they’re 63rd, conceding 374.6 yards per contest.
  • Offensive guards Charles Jagusah (arm) and Peter Jones (ankle) are questionable.

NC State vs. Notre Dame Pick

Spread Pick for NC State vs. Notre Dame

  • NC State Wolfpack +23.5 (-110) (5 units)

Notre Dame is back on track after losing those opening games to ranked opponents at the beginning of the year. However, I’m still not convinced that the Irish are some juggernaut program in 2025 that is going to cruise past a respectable team like NC State. You can easily poke holes in all three of Notre Dame's wins, and I’d say that they still don’t have a quality win yet this year. Purdue (56-30) is atrocious, Arkansas’ (56-13) defense is one of the worst in the nation, and Boise State (28-7) is a shell of itself without Aston Jeanty leading the way.

23.5 points is just too lofty of a number for me to lay with this Notre Dame team that’s still figuring itself out with a freshman quarterback in CJ Carr. On the flip side, this NC State team has a dynamic offense. We’ve seen Notre Dame’s defense falter at times this season, and I think this CJ Bailey-Hollywood Smothers duo can keep it close.

Over/Under Pick for NC State vs. Notre Dame

  • Over 59.5 (-105) (5 units)

I’m locking in the over in this one. Picking it back up with NC State, they have a good enough offense to keep this game relatively close. They’re averaging 29.4 points per game (51st) and putting up more than 400 yards per contest. Notre Dame has conceded 27+ points in three out of their five games this year.

Meanwhile, Notre Dame’s offense is truly a juggernaut. CJ Carr still needs to refine his skills, with a top-tier offensive line and a two-headed monster in the rushing game, they have all of the weapons to mask Carr’s inexperience. They’re putting up 40.8 points per game, which is ninth in the country. They’re at home, which is favorable to Carr, and I think they hang another 40+ point performance this weekend. Both offenses should score with relative ease – give me the over.

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