Nevada vs. Wyoming Picks and Prediction, Saturday, November 22, 2025
In a Mountain West Conference matchup on Saturday at War Memorial Stadium, Wyoming plays host to Nevada. Wyoming (4-6, 2-4 MWC) has lost two in a row and Nevada (2-8, 1-5 MWC) snapped their long losing streak with their first conference win in their last game. Check out all the info for this game in this in-depth Nevada vs. Wyoming prediction.
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Wyoming comes into this game as a seven-point favorite with the total sitting at 40.5.
Not the Same Nevada Team
Nevada had lost seven in a row, only averaging 13.6 ppg and they were a different team in their last game in a 55-10 home blowout win over San Jose State. It was their first MWC win and first win over an FBS team, forcing five turnovers and outgaining the Spartans 413 yards to 270 yards. Carter Jones was 16/19 for 195 yards with two TD and no INT, Caleb Ramseur rushed for 128 yards with a TD, and Dakota Thomas led the way with 85 receiving yards. The Wolf Pack easily covered the spread as a 9.5-point underdog, and they are 4-5-1 ATS on the season.
The 55 points scored in the last game were, by far, the most that Nevada has scored, and, on the season, they only rank 127th, averaging 18.1 ppg. They rank tied for 93rd in defensive scoring (28.1 ppg), only 125th in passing yards per game, and 84th in rushing yards per game.
Carter Jones (856 yards, 5 TD, 8 INT) is one of three QBs that has seen action this season and had five picks and no TD in his previous two starts. Ramseur i(500 yards, 3 TD) is the leading rusher and had only totaled 136 yards in four games before 128 in the last one. The Wolf Pack will face a Wyoming defense that ranks a solid 19th against the pass but only 107th against the run.
The Wolf Pack have several players listed as questionable, including their third-leading running back and third-leading WR.
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Wyoming’s Offense Falls Flat
Wyoming only ranks 128th in the nation, averaging 17.8 ppg, but their offense has even been worse in losing their last two games, only totaling 10 points. In their last game, they were on the road in a 24-3 loss to Fresno State, where they were outgained 311 yards to 184 yards and were shut out in the last three quarters. Two QBs saw action with Kaden Anderson passing for 64 yards with an INT and even in the bad loss, Samuel Harris had a good game with 108 rushing yards. The Cowboys failed to cover as a 3-point underdog and have not covered in the last two games after doing so for three in a row.
While Wyoming is one of the lowest-scoring teams in the nation, it ranks a respectable 33rd in defensive scoring (20.6 ppg). Anderson (1,791 yards, 11 TD, 10 INT) is the starter and in the last two games, he has failed to pass for over 93 yards and has no TD and four picks. Harris (546 yards, 1 TD) is one of three players with over 330 rushing yards and had only totaled 52 yards before 108 in the last game. The Cowboys face a Nevada team that ranks 66th in pass defense and 64th in run defense.
No key players for the offense are injured but four players on the defensive side of the ball are listed as questionable.
Nevada vs. Wyoming Pick
Spread Pick for Nevada vs. Wyoming
- Wyoming -7 (+4 Units)
Nevada is coming off their first FBS win and first MWC win, while Wyoming has lost two in a row. The Cowboys did play the top two teams in the conference in their last two games, and both were on the road, and they are 4-1 at home this season. The Wolf Pack are winless on the road this season and while they scored 55 points in their last game, they have not been a good offensive team on the season. They will not get much going on offense, facing a solid Wyoming defense. The Cowboys are a lower-scoring team but they have totaled 63 points in winning their last two home games. In terms of the Nevada vs. Wyoming prediction, the Cowboys will have a good game on defense, run the ball well, and play another good game at home, winning and covering the spread.
Over/Under Pick for Nevada vs. Wyoming
- Under 40.5 (+4 Units)
The last four games for Wyoming have gone Under, and that is the pick I am leaning towards in this game. Nevada lit it up for a season high, by far, 55 points in their last game, and one of the reasons was that they forced five turnovers. They also faced a San Jose State team that ranks tied for 123rd in the nation. The Wolf Pack will get nowhere near that many turnovers in this game and is facing a Wyoming team that ranks 33rd in defense, so they will struggle to score points. The Cowboys are also low low-scoring team and have only totaled 10 points in the last two games. They have played well on offense in their last two home games, but they will not light up the scoreboard in this one. Nevada has had issues on defense this season but has not given up more than 24 points in three of their last four games. This game will be a defensive battle and a low-scoring affair, so the Under is the pick.
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