North Texas Mean Green at Charlotte 49ers Picks and Prediction for Friday, October 24, 2025
The North Texas Mean Green travel to Charlotte to face the 49ers at Jerry Richardson Stadium on Friday at 7:00 p.m. ET on ESPN2. North Texas enters at 6-1 overall and 2-1 in American Athletic Conference play after routing UTSA 55-17, while Charlotte sits at 1-6 and remains winless in conference play following a 49-14 home loss to Temple. Your Saturday scout: NCAAF predictions for North Texas Mean Green at Charlotte 49ers you can trust.
North Texas Mean Green Look to Keep Rolling
North Texas continues to rank among the most productive offenses in the country, averaging 456 total yards per game, which is 26th nationally. Quarterback Drew Mestemaker has thrown for 1,860 yards with 17 touchdowns and just three interceptions while completing 66 percent of his passes. The passing attack averages 274.7 yards per game, good for 27th in the nation. Running back Caleb Hawkins helps to balance the offense with 499 yards on 75 carries and seven touchdowns, helping the Mean Green average 181.3 rushing yards per game.
This balanced attack has powered North Texas to 45 points per game, the top scoring mark in the nation. Receiver Wyatt Young has become Mestemaker’s go-to target with 396 yards and six touchdowns on 26 receptions. The Mean Green’s offensive line has also protected well, limiting negative plays and sustaining drives. North Texas has a red zone success rate of 95.2 percent that ranks 16th in the FBS. Defensively, the unit has been opportunistic, producing a +10 turnover margin, which ranks second nationally.
North Texas was dominant in its most recent outing, defeating UTSA 55-17. Mestemaker threw for 277 yards and four touchdowns, while Hawkins contributed 133 rushing yards and another score. Young posted 102 yards receiving and three touchdowns. The defense limited UTSA to just 17 points, showing improved pressure, after struggling against USF the previous week.
Injuries:
- M. Coleman (WR) – Questionable,
- Z. Scott (DL) – Questionable
- C. Vaughn (TE) – Questionable
- J. Becks (RB) – Questionable
- D. Shaw (OG) – Out
- F. Vailea II (DL) – Out
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Charlotte 49ers Searching for Answers
Charlotte has struggled to find success on either side of the ball this season, ranking 122nd nationally with just 314.3 total yards per game. Quarterback Conner Harrell has thrown for 737 yards with four touchdowns and two interceptions while completing 67 percent of his passes, but he's out with a knee injury The offense averages 207.1 passing yards per game and just 107.1 on the ground, placing 120th in rushing offense. Rod Gainey Jr. leads the backfield with 201 yards on 51 carries and one touchdown, while receiver Javen Nicholas has produced 354 yards on 34 catches.
The 49ers’ scoring offense sits near the bottom of the FBS at 17.1 points per game. The defense has struggled even more, surrendering 438.4 yards per game, which is 124th nationally. Charlotte has allowed 34.9 points per game, ranking 127th. The biggest issues have come against the run, where opponents average 216.6 rushing yards per contest, and in the red zone, where the 49ers allow scores on 96 percent of opponent trips (131st in FBS). The 49ers' turnover margin of -10 ranks 133rd, a key factor in the current four-game losing streak.
Charlotte’s latest outing was a 49-14 home defeat to Temple. Quarterback Grayson Loftis completed just 10 of 22 passes for 108 yards, one touchdown, and one interception. Jake Davids led the ground game with 42 yards, while Nicholas caught five passes for 50 yards. The 49ers managed only 257 total yards and allowed 7.7 yards per play, continuing a trend of stalled drives.
Injuries:
- P. Startz (LB) – Questionable
- E. Mason (WR) – Questionable
- J. Bearns III (TE) – Questionable
- J. King (OG) – Questionable
- D. Wallace (DL) – Questionable
- G. Laskey (TE) – Out
- I. Bullerdick (OG) – Out
- U. Rockhead (OG) – Out
- O. Davis (OG) – Out
- A. Tifase (DL) – Out
- D. Kelley (OG) – Out
- A. Adair (OG) – Out
- J. Olson (WR) – Out
- H. Rutledge (RB) – Out
- C. Harrell (QB) – Out
- D. Burgess (DL) – Out
- J. McGowan (WR) – Out
North Texas Mean Green at Charlotte 49ers Pick
Spread Pick for North Texas vs. Charlotte
- North Texas -27.5 (4 Units)
North Texas brings one of the nation’s most productive offenses against a Charlotte defense ranked near the bottom in every major category. The Mean Green average 45 points per game and just held UTSA to 17, while Charlotte allows 34.9 per contest and has been outscored by an average of 18 points in conference play. The turnover disparity - +10 for North Texas versus -10 for Charlotte is further evidence of the gap between the two. Expect the Mean Green to control this game early behind Mestemaker’s passing and a potent red-zone attack.
Over/Under Pick for North Texas vs. Charlotte
- Under 62.5 (4 Units)
While North Texas can score in bunches, Charlotte’s offensive limitations make it unlikely this game reaches the mid-60s. The 49ers average only 17 points per game and have failed to score more than 26 in any of their last four contests. North Texas should build a comfortable lead and use the run in the second half, slowing the pace. The Mean Green’s improving defense, particularly against weaker opponents, should hold Charlotte under 20 points, keeping the total below the posted number.
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