Ohio State Buckeyes vs. Purdue Boilermakers, Preview, Odds, Prediction and Picks for Saturday, November 8, 2025
Make the big play on Saturday with our Ohio State vs. Purdue predictions. The No. 1-ranked Buckeyes (8-0 SU, 7-0-1 ATS) remained undefeated with a 38-14 win over Penn State at home last weekend as -18.5 favorites. The Boilermakers (2-7 SU, 3-5-1 ATS) played tough but could not get by No. 21 Michigan on the road last week, falling 21-16 as +21 underdogs. Kickoff from Ross-Ade Stadium in West Lafayette, Indiana, is scheduled for 1:00 EST. Do you need a boost in your handicapping? Try our NCAAF Betting Picks.
Ohio State can’t look ahead
The top-ranked Buckeyes are one of just four unbeaten teams remaining in the FBS. In defense of the National Championship, they’ve won eight games this season by an average of 29.8 points. They have three games left with bottom-half Big Ten teams before the regular season finale versus No. 21 Michigan.
Through their eight games, the Ohio State offense is averaging 36.6 points per game, fourth most in the Big Ten, and 437.5 total yards, fifth in the conference. They have the second-best passing offense in the Big Ten, averaging 284.3 yards per game. Freshman Justin Sayin threw for over 300 yards and 4 TDs for a second straight game last weekend, and on the year, he has 2,188 passing yards, 23 TDs, and 3 INTs. He’s also been sacked only three times. Jeremiah Smith has been his top target, catching 55 passes for 725 yards and 9 TDs. The Buckeyes are rushing for 153.3 yards per game, led by Bo Jackson’s 538 yards on 81 carries. CJ Donaldson has chipped in with 266 yards and 7 TDs on 67 rushes.
Ohio State possesses the top scoring defense in the land, allowing just 6.9 points per game. They are also tops in the country, allowing only 214.8 total yards each week. Against the run, they are giving up only 81.8 yards, and versus the pass, 133 yards per game. The Buckeyes are third in the conference with 25 sacks, complemented by 5 interceptions. Caden Curry is third in the Big Ten with 7 sacks, and Avrell Reese is tied for fourth with 6.5 sacks. Reese also leads the team with 54 tackles.
Sign Up for StatSalt News Alerts, Get Free Picks and Discounts
Subscribe Now
Team notes
- Reese earned the Chuck Bednarik National Defensive Player of the Week and Big Ten Defensive Player of the Week for his 12-tackle performance versus Penn State.
- Sayin was named a semifinalist for the Shaun Alexander Freshman of the Year Award.
- Four different tight ends have touchdown catches.
- The 55 total points allowed by the defense is the fewest through eight games since the 1973 team allowed only 20 points.
- The Buckeyes' 12-game winning streak is the longest in the country.
Purdue with chances to spoil
Tasked with finishing the season versus four straight Top 25 teams, including the two current top teams in the land, the Boilermakers are just looking to be respectable at this point. They come into this game having lost seven straight and they are 0-6 SU in the Big Ten.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Stephen Nover | +1,126.00 |
| 2 |  David Delano | +996.00 |
| 3 |  Rob Vinciletti | +740.00 |
| 4 |  Jackie Mack | +651.00 |
| 5 |  David Hess | +608.00 |
Purdue comes to the table with the third-lightest offense in the Big Ten, averaging 22.1 points per game. They are 10th in the conference with 376.4 total yards and 234.1 passing yards per game. Though he hasn’t thrown an interception over his last three games, Ryan Browne averaged just 93.7 passing yards. This season, the sophomore QB has 1,822 passing yards with 9 TDs, 7 INTs and has been sacked 14 times. Michael Jackson III is tied for third in the Big Ten with 50 catches, 456 yards, and a touchdown. The team ranks 11th in the conference with 142.3 rushing yards per game. Malachi Thomas had a season-high 15 carries last week for 68 yards. He is the team’s top active rusher with 206 yards.
Defensively, Purdue is 15th in the conference, giving up 27 points per game. They rank second-to-last in the Big Ten in yards, allowing 395 total yards each week. The Boilermakers have the third-worst pass defense in the conference, giving up 234.4 yards, and fourth fourth-worst rush defense, allowing 160.6 yards per game. They’ve been able to get to the opposing QB for 21 sacks, but their 3 interceptions are tied for second-fewest in the Big Ten. Tahj Ra-El and Mani Powell are tied for the conference lead with 81 tackles apiece, and Charles Correa is fourth with 78. CJ Nunnally IV leads the team with 5 sacks.
Team notes
- In conference games, Jackson has a Big Ten-best 39 catches for 315 yards.
- Devin Mockobee, fourth all-time on Purdue’s rushing yards leaderboard, had season-ending ankle surgery following a run of playing 37 straight games for the Boilers.
- Ra-El has three straight double-digit tackle performances.
- Spencer Porath is 10th in the country in field goal percentage (91.7%).
- Purdue allows 2.7 yards per punt return, the 12th-best punt return defense in the country.
Ohio State vs. Purdue Picks
Spread Pick for Ohio State vs. Purdue
- Ohio State -29 (5 units)
The Boilermakers couldn’t get off the mat when these two met last season as the Buckeyes took a 45-0 victory at home. Ohio State has a commanding 45-15-2 SU lead in the head-to-head with the Boilermakers. In conference play, the Boilermakers are 0-3 SU at home. Ohio State’s most recent road win was a 34-0 shutout at Wisconsin, so they can absolutely go on the road and win by this margin. They’ve won two of their last four games by at least that margin, so they are in full stride in all aspects of the game. Sayin has thrown for over 300 yards in three of the last four games and the defense allowed an average of 8.3 points per game. Purdue struggles enough to score; now they have to try and do so against the best scoring defense in the land. Ohio State is 5-1 SU and 4-2 ATS in their last six games against the Boilermakers.
Take the Buckeyes giving the points.
Over/Under Pick for Ohio State vs. Purdue
- Under 48.5 (4 units)
When these two teams met last season, they combined for 45 points, hitting the under against a 56-point total. Of course, all of those points were scored by Ohio State, and we might be in for another one of those one-sided affairs here. While I do have tons of faith in the Buckeyes' offense, they are still averaging just 34.4 points per game in conference play. Purdue doesn’t have the staunchest of defenses, but I also cannot see them yielding 49 points at home. On the flip side, I can see the Ohio State defense keeping the Boilers off the board. The under is 4-2 in the last six meetings.
Take the under.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $200 in Bonus Bets Win or Lose
