Ohio State vs. Washington Prediction and Picks for Saturday, September 27th, 2025
Big Ten football season is upon us, and two undefeated schools square off on Saturday when the Washington Huskies (3-0, 0-0 B1G) host the #1 Ohio State Buckeyes (3-0, 0-0 B1G). We’ve got you covered with our Ohio State vs. Washington prediction. Kickoff is scheduled for 3:30 ET from Husky Stadium in Seattle, WA. Don’t get sacked this football season! Try our College Football Picks!
#1 Buckeyes Looking Fierce in 2025
Coach Ryan Day and his Ohio State Buckeyes are coming off of a national championship victory in January 2025, and it appears they’re ready to defend the title. There were some questions surrounding the program, with a couple of coordinators departing and a freshman quarterback taking the wheel of the offense. However, first-year coordinator Matt Patricia and his defense have stood up well, while redshirt freshman quarterback Julian Sayin has looked serviceable. Ohio State is 3-0 out of the gate, taking care of #1 Texas (14-7), Grambling (70-0), and Ohio (37-9). They are coming off of a bye week in week 4.
Circling back to Sayin, he has looked solid so far this season. The signal caller has thrown for 779 yards on a 78.9% completion rate, adding eight touchdowns and three interceptions. His top target is none other than WR Jeremiah Smith, who has 315 yards and three touchdowns on 20 catches. RB Bo Jackson has spearheaded the rushing attack, gaining 217 yards and a touchdown on 18 carries (12.1 YPC).
- The Buckeyes have a current win total of 10.5 (-180/+140), and they’re the betting favorites (+200) to win the conference title.
- Ohio State’s offense has been solid this season, ranking 70th in scoring (25.5 PPG), while putting up 387.5 yards per game (59th).
- On the defensive side, the Buckeyes are third this year, allowing only 8.0 points per game. In terms of yardage, they’re 13th, conceding 258.5 yards per contest.
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Huskies are Perfect in 2025
This is the second year of the Jedd Fisch era for the Washington Huskies, and he’s looking to build on a 6-7 (4-5 B1G) campaign in 2024. His Huskies are a perfect 3-0 out of the gate, taking down Colorado State (38-21), UC Davis (70-10), and Washington State (59-24), most recently. Washington brought in two new coordinators this season, with Jimmie Dougherty running the offense and Ryan Walters taking over the defense. The Huskies are 2-1 ATS and they’ve seen all three of their games go over the total.
In terms of personnel, it’s QB Demond Williams Jr. leading the offense this season. The sophomore signal caller has logged 778 passing yards on a 73.5% completion rate, while adding six touchdowns and no interceptions. RB Jonah Coleman has handled a bulk of the rushing load, registering 347 yards and nine touchdowns on 51 carries (6.8 YPC). WRs Denzel Boston (249 yards, 3 TD) and Dezmen Roebuck (104 yards, 1 TD) lead the receiving group.
- Washington’s updated win total is 8.5 (-125/-105), and they’re priced at +4000 to win the conference title.
- Offensively, the Huskies are scoring 48.5 points per game (third), while averaging 491.0 yards per week (14th).
- Defensively, they are 48th in the country this year, conceding 22.5 points per game. They’re allowing 285.0 yards per contest, which is 22nd.
Ohio State vs. Washington Pick
Spread Pick for Ohio State vs. Washington
- Washington Huskies +8.5 (-110) (5 units)
I won’t be completely shocked if Washington manages to pull off the outright upset at home on Saturday afternoon. The Huskies are a perfect 20-0 SU in their last 20 home games. They’ve looked sharp on both sides of the ball, and they’ve yet to score fewer than 38 points in all three of their games this season.
There is a large travel disadvantage for Ohio State, which has to move across several different time zones to play this game. They’ll also turn to a freshman quarterback in Julian Sayin, who already has three interceptions in three games this year. This will be a hostile environment for the young quarterback, so if he turns the ball over a time or two, it’ll easily open the door for this explosive Huskies offense to cover the large number at home. I’ll take the points with Washington.
Over/Under Pick for Ohio State vs. Washington
- Over 51.5 (-110) (5 units)
I’ll play the over in Seattle on Saturday. The Huskies have been serviceable defensively this year, but not lights out. They’re conceding 22.5 points per game against FBS-level competition, and now they’ll welcome in a Buckeyes receiving group that’s one of the best in the nation.
As for Ohio State, they really haven’t been tested this year defensively. Their toughest game was Texas in week 1, but that was a spot where they were home and hosting a freshman quarterback as well. Now they’ll take on a Washington team that’s putting up 48.5 points per game against FBS-level opposition. Quarterback Demond Williams Jr. is a threat in both the passing attack and rushing attack, which could throw a wrench into things defensively for first-year coordinator Matt Patricia. I expect both offenses to score into the mid-20s and for this game to go over the number.
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