Ole Miss vs Vanderbilt Picks and Prediction for Saturday October 10 2026
Weather could play a major factor on Saturday, October 10, when the Ole Miss Rebels travel to FirstBank Stadium in Nashville to take on the Vanderbilt Commodores. The game is set to kick off at 12:30 PM EST. The Rebels are the favored team sitting at -9.5 and the total is sitting at 54.5. Make sure you are ready for all the college football action with our free college picks.
Ole Miss Looks To Avoid Defensive Lapses
The Ole Miss Rebels made it to the College Football Semifinals last season and have managed to put all the Lane Kiffin distractions in the rear view mirror. The ninth-ranked Rebels (3-1) have already notched ranked victories against Louisville (41-38) and LSU (32-24). Ole Miss is fresh off a bye and hopefully used the time to sort things out on a defense that surrendered 52 points in an ugly road loss against Florida.
Ole Miss trailed the 21st ranked Gators 17-6 at halftime, but were gashed for over 300 yards by a potent ground attack. Senior QB Trinidad Chambliss completed 25 of 34 passes for 298 yards and a touchdown. Chambliss added 44 rushing yards and two scores. Deuce Alexander caught seven passes for 134 yards and a touchdown.
Ole Miss leads the SEC Conference in passing at 440 yards per game and has no problem scoring (35.5 ppg). The Rebels are tied for first nationally in red zone offense (100%), with an impressive 14 touchdowns in 16 opportunities. Ole Miss ranks last in the conference in total defense and is giving up 30.8 points per game.
Vanderbilt Continues To Impress
The Vanderbilt Commodores have made major strides as a football program, but entered the year having to replace Heisman Trophy finalist QB Diego Pavia. The Commodores (3-2) started the season with three straight victories, which included a gift-wrapped 35-31 home victory versus NC State. Last week, Vanderbilt was outclassed during a 38-14 road victory against second-ranked Georgia.
Vanderbilt evened the score late in the first quarter on a 60-yard touchdown pass from Blaze Berlowitz to Junior Sherrill. Senior RB Sedrick Alexander carried eight times for 35 yards and a score. Sherrill finished with a game-high 107 receiving yards for the Commodores, who were outgained by a 471-293 margin.
Vanderbilt has scored just 29 points total in losing their first two SEC Conference contests. The Commodores rank near the bottom of the conference in total offense and are averaging 25.4 points per game. Vanderbilt is better on the defensive side of the ball and has limited teams to 25 points on average.
Ole Miss vs Vanderbilt Picks and Prediction
Pick: Vanderbilt +9.5
Ole Miss head coach Pete Golden was promoted from defensive coordinator during the College Football Playoff, but his team’s defense is lacking. The Rebels rank near the bottom of the nation in tackling and that could prove costly against a unique Vanderbilt run game. With this number hovering around ten, take the points with the home underdog.
Pick: Under 54.5
This total opened at 57.5 and was quickly bet down. With heavy rain predicted and wind gusts of up to 30 mph, conditions are not favorable for scoring. Ole Miss plays at a fast tempo, but will struggle to generate their normal amount of pass explosives. Vanderbilt is built for these conditions and will try to grind clock and keep Chambliss on the sidelines.