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Pinstripe Bowl Predictions, Picks, Odds, and Line Movement for Penn State vs. Clemson December 27

By: Kyle Kargel Published 12/25/2025, 10:49 AM ET

Penn State vs Clemson picks headline this postseason matchup at Yankee Stadium, and this Pinstripe Bowl sets up as a fascinating handicap shaped by history, opt-outs, and bowl preparation. For bettors searching for sharp college football picks, this game offers several data-driven angles worth isolating before kickoff.

TLDR - Picks and Prediction

  • Spread: Clemson -3.5
  • Total: Over 48
  • Projected Final Score: Clemson 27, Penn State 23

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  • Penn State is 1-5 in non-playoff and non-New Year’s Six bowl games since 2010.
  • Penn State’s lone win in that span came in the Pinstripe Bowl.
  • The over has gone 4-1-1 in Penn State’s last six games.
  • Clemson has won at least one postseason game every season since 2011.
  • Clemson closed the regular season with four straight wins.
  • The Pinstripe Bowl has averaged 53.1 points per game over its 14-year history.

Odds and Line Movement

Team Spread Odds
Penn State +3.5 -120
Clemson -3.5 -102
Total Over Under
48 -110 -110

Line Movement - Spread

Date Penn State Clemson
12/07 +1.5 -1.5
12/09 +3.5 -3.5
12/23 +3.5 (-120) -3.5 (-102)

Line Movement - Total

Date Over Under
12/07 48 (-105) 48 (-115)
12/08 48 (-110) 48 (-110)

Penn State vs Clemson Game Preview and Analysis

Penn State enters this bowl with a complicated postseason profile. While the Nittany Lions enjoyed success in New Year’s Six games under James Franklin, their performances in mid-tier bowls have often fallen flat. Since 2010, Penn State has managed just one win in these spots, and fittingly that victory came in this very bowl during Franklin’s first season, making Yankee Stadium a symbolic bookend for the era.

Clemson approaches bowl season from a very different angle. Dabo Swinney has built a reputation for getting his team ready when the calendar flips to December, and the Tigers’ streak of postseason success dating back to 2011 speaks for itself. Clemson ended the regular season on a four-game winning streak, showing improved consistency on both sides of the ball heading into this matchup.

Both teams are dealing with significant roster absences, but the impact appears heavier on the defensive side. Clemson will be missing a large group of contributors, while Penn State also enters shorthanded. With both starting quarterbacks expected to play, offensive continuity should be stronger than defensive cohesion, especially in a bowl setting where preparation time is split between football and roster management.

Weather is always a variable at Yankee Stadium in late December, but even with cold conditions, the Pinstripe Bowl has historically produced points. With defensive opt-outs and injury absences on both sides, I see more paths to scoring than the opening total suggests.

Key Injuries and Notes (PSU vs CLEM)

  • Clemson will be without 26 players: 17 due to injuries, five transfers, and four early NFL Draft departures.
  • Both starting quarterbacks are expected to play.
  • Penn State enters the game under interim head coach Terry Smith.
  • Weather conditions at Yankee Stadium could be a factor but have not suppressed scoring historically.

Final Score Prediction

Clemson’s bowl preparation track record combined with Penn State’s struggles in this tier of postseason games give the Tigers a narrow edge. Defensive absences should open the door for enough scoring to push this game past the total.

Final Score: Clemson 27, Penn State 23

ATS and Total Picks

  • Against the Spread: Clemson -3.5
  • Total: Over 48
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