South Carolina Gamecocks at Missouri Tigers Picks and Prediction for Saturday, September 20, 2025
Get ready for an exhilarating Week 4 SEC clash as the South Carolina Gamecocks battle it out with the 23rd-ranked Missouri Tigers in our Gamecocks vs. Tigers prediction. Set to unfold at Memorial Coliseum on September 20th at 7:00 PM ET, this game, airing on ESPN, promises an exciting matchup with two teams looking to be legitimate threats for the College Football Playoff. With these teams looking to step up in this matchup, let's dive into the stats, injuries, and key insights to preview what's in store. Your Saturday scout: NCAAF predictions for the South Carolina Gamecocks at the Missouri Tigers you can trust.
Gamecocks Looking to Get Ranked
The South Carolina Gamecocks (2-1, 0-1 SEC) are coming off a 31-7 home loss to the Vanderbilt Commodores in their first SEC game last Saturday. South Carolina’s offense is led by quarterback LaNorris Sellers, who has been able to complete 29-of-45 passes for 431 yards with two passing touchdowns and one interception to begin the season. He is also dealing with an injury that has him questionable for this game. He sustained an upper-body injury late in the second quarter against the Commodores. If he can't go, Luke Dota will likely start against Missouri. He completed 18-of-27 for 147 yards and an interception against the Commodores, but South Carolina produced no points when he was on the field.
The Gamecocks' total offense stands at 303.0 yards per game (118th in NCAA), with rushing accounting for a lesser 110.0 yards (118th). The passing game has been underwhelming compared to the rest of the country, with an average of 193.0 yards per game (95th).
Defensively, South Carolina has controlled things as they are allowing 309.7 total yards per game (47th), with their pass defense standing out as they are allowing a 57.3 completion percentage through the first few games of the season. The defense for the Gamecocks has been putting the offense in a position to continue winning games.
Injury Report for South Carolina
- Wide receiver Mazeo Bennett Jr: Undisclosed (Questionable)
- Quarterback LaNorris Sellers: Undisclosed (Questionable)
- Tight end Michael Smith: Undisclosed (Doubtful)
- Cornerback Judge Collier: Knee (Doubtful)
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Tigers Looking for Answers
The 23rd-ranked Missouri Tigers are looking to get off to remain undefeated as they start SEC play after their 52-10 home win over the Louisiana Ragin' Cajuns last week. Quarterback Beau Pribula has been impressive this year as he completed 68-of-89 passes for 791 yards with seven touchdown passes to one interception. The former Penn State backup is completing 76.4% of his passes and also has three rushing scores.
As a team, they are ranked fourth nationally in total yards, averaging 587.0 yards per game. Missouri’s passing offense, which averages 284.7 yards per game (29th), has been the “weaker” part of the offense thus far. The rushing game, contributing 302.3 yards per game (sixth nationally), has been able to completely overwhelm the opposing defense. The Tigers also rank eighth in the nation in scoring with 51.7 points per game.
The Tigers’ defense, allowing an average of 192.3 total yards per game (fifth), has been their strength this season. Their pass defense, in particular, has been impressive, conceding only 100.0 yards per game (fifth). Their rush defense, allowing 92.3 yards per game (27th), remains a strong point and will be a critical force for the result of this game.
Injury Report for Missouri
- Offensive guard Logan Reichert: Undisclosed (OUT)
- Quarterback Sam Horn: Leg (OUT)
- Kicker Blake Craig: Undisclosed (OUT)
South Carolina Gamecocks vs Missouri Tigers Pick
Spread Pick for South Carolina vs. Missouri
- Missouri Tigers -9.5 (4 units)
These teams have been able to step up this season, but the questionable status on LaNorris Sellers makes this one a bit more difficult to navigate. Even if he is officially able to play, Sellers has not been as good as advertised, while the Tigers have a strong pass defense that can bottle up his connection to wide receiver Nyck Harbor. Missouri just appears to be a big step above where South Carolina is, specifically offensively, so take the Missouri Tigers to cover the spread and move up the AP Poll.
Over/Under Pick for South Carolina Gamecocks at Missouri Tigers
- Under 48.5 (5 units)
This game screams SEC hard-nosed football. Yes, LaNorris Sellers and Beay Pribula can have some big games, but this feels like some ground-and-pound offense with strong defenses. South Carolina limits the opposing quarterback’s ability to complete passes, while Missouri can silence the opposing offense in a hurry. With guys like Josiah Trotter and DQ Smith on the field, finding ways to be involved all the time defensively, go with under 48.5 total points here.
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