South Carolina vs. LSU Prediction and Picks for Saturday, October 11th, 2025
Use Code SSWC There’s a marquee SEC showdown on Saturday night’s schedule, and this game pits the South Carolina Gamecocks (3-2, 1-2 SEC) against the #11 LSU Tigers (4-1, 1-1 SEC). We’ve got you covered with our South Carolina vs. LSU prediction. Kickoff is scheduled for 7:45 ET from Tiger Stadium in Baton Rouge, LA. Looking to win big this football season? We have the best College Football Picks to help you out!
Gamecocks Bounce Back, Hammer Wildcats
The expectations were high entering the season for the South Carolina Gamecocks, but they’ve fallen flat on their faces come conference play. South Carolina is 3-2 out of the gate, with their losses coming against Vanderbilt (31-7) and #23 Missouri (29-20). Following this two-game slide, they did bounce back with a resounding 35-13 home win over Kentucky. South Carolina also has a season-opening non-conference Power Four win against Virginia Tech (24-11). From a sports betting perspective, the Gamecocks are 3-2 ATS, and they’ve gone 3-2 to the under.
QB LaNorris Sellers has dealt with some injury issues this season, but he has played in all five games. He was a Heisman favorite coming into the year, but hasn’t really lived up to the billing. Sellers has 886 passing yards on a 66.7% completion rate to go along with four touchdowns and one interception. RB Rahsul Faison has spearheaded the rushing attack, and he only has 163 yards and three touchdowns on 41 carries (4.0 YPC). Out wide, WRs Vandrevius Jacobs (323 yards, 2 TD) and Nyck Harbor (220 yards, 1 TD) have emerged as the top targets.
- Offensively, the Gamecocks are scoring 21.5 points per game (93rd), while averaging 322.5 yards per week (110th).
- Defensively, they are 33rd in the country this year, conceding 21.0 points per game. They’re allowing 336.8 yards per contest, which is 36th.
#11 Tigers Drop To 4-1
Meanwhile, Coach Brian Kelly and his LSU Tigers are always under the media spotlight, and the program had high expectations coming into 2025. They got out to an impressive 4-0 start, notching notable wins over #4 Clemson (17-10) and Florida (20-10). However, their 4-0 record was snapped on the road against #13 Ole Miss (24-19) last time out. That defeat came on September 27th, so the Tigers will be coming off of a bye on Saturday. LSU is priced at +175 to make the CFP and +1800 to win the SEC. From a game-by-game perspective, they’re 2-3 ATS and 4-1 to the under.
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Like the above-mentioned Sellers, QB Garrett Nussmeier was one of the Heisman frontrunners entering the season. He has been serviceable this season, but not overpowering. Nussmeier has 1,159 passing yards on a 67.3% completion rate, adding seven touchdowns and three picks. WR Aaron Anderson is his favorite receiver, and he has 305 yards on 23 receptions. Anderson’s listed as questionable (hip/knee). As for the rushing attack, RB Caden Durham, who’s probable (ankle), has led the way with 213 yards and two touchdowns on 52 totes (4.1 YPC).
- LSU’s offense has been underwhelming this season, ranking 103rd in scoring (19.8 PPG), while putting up 324.8 yards per game (108th).
- On the defensive side, the Tigers are eighth this season, allowing 12.8 points per game. In terms of yardage, they’re 23rd, conceding 316.3 yards per contest.
South Carolina vs. LSU Pick
Spread Pick for South Carolina vs. LSU
- South Carolina Gamecocks +9.5 (-115) (5 units)
I’m taking the points with South Carolina in this one. They’re 3-2 SU this season, but the 31-7 loss to Vanderbilt saw star QB LaNorris Sellers exit early. I don’t really hold the 29-20 road loss to Missouri against them, as we’re seeing that Mizzou is shaping up to be a powerhouse. If the Gamecocks can keep it inside of 10 points against Mizzou, then they should have no issues hanging around with an LSU offense that has yet to score more than 20 points against a Power Four opponent this season.
Circling back to Sellers, it’s his big-play ability that is the final factor for me. He has dual-threat capabilities, which can always be a nightmare to gameplan for – even on an extra week of rest like LSU has. The Gamecocks are 12-5 ATS in their last 17 games, and I think that’s a trend that continues on Saturday night.
Over/Under Pick for South Carolina vs. LSU
- Under 44.5 (-112) (5 units)
I’ll play the under in this game. I really haven’t been impressed with LSU’s offense this season. Against FBS competition, the Tigers are scoring only 19.8 points per game (103rd). They also have some injury concerns with RB Caden Durham (ankle) and WR Aaron Anderson (hip/knee) listed on the injury report. South Carolina just held Kentucky to 13 points last time out, and this is the third time in five games that they’ve limited an opponent to less than 14 points.
On the flip side, this will be a tall task for South Carolina’s offense. They’re taking on an LSU defense in a hostile environment, and the Tigers have had an extra week of preparation with the bye week. The under is 5-2 in their last seven games, while going 4-1 in LSU’s last five outings. I’m taking the under.
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