Southeastern Louisiana vs South Alabama Picks and Prediction for Saturday September 5 2026

By: Kim Smith Published 09/02/2026, 06:25 AM ET

Southeastern Louisiana travels to Mobile to face South Alabama on Saturday, September 5. Kickoff is scheduled for 7:00 PM ET. South Alabama is currently favored by 13.5 points, while the total is 52.5. Southeastern Louisiana already has a game under its belt, while the Jaguars will be making their 2026 debut. Get into the action with our free college football picks.

Southeastern Louisiana Has Already Played

Southeastern Louisiana has the situational benefit of live game experience.

The Lions have already dealt with substitutions, communication and real-game execution while South Alabama will be experiencing those issues for the first time this season.

They are also receiving nearly two touchdowns.

That combination makes Southeastern Louisiana interesting against the spread.

South Alabama Gets Home Field

South Alabama should have the overall depth advantage and gets the matchup at home.

The Jaguars are appropriately favored and should have the better chance to win outright.

However, South Alabama was only 5-7 ATS last season and went 3-4 in games in which it was favored on the moneyline.

Those numbers don't determine this matchup, but they don't encourage laying nearly two touchdowns either.

Southeastern Louisiana vs South Alabama Picks and Prediction

Pick: Southeastern Louisiana +13.5

I'm taking Southeastern Louisiana +13.5. The Lions have already played, they're receiving nearly two touchdowns, and South Alabama is making its season debut. The Jaguars can win the game without creating enough separation to cash. Something around South Alabama 30, Southeastern Louisiana 21 gives the home team a nine-point victory while comfortably rewarding the underdog. Take Southeastern Louisiana +13.5.

Pick: Under 52.5

I'll take Under 52.5. Southeastern Louisiana staying within the spread doesn't necessarily require a shootout. South Alabama can control the game while keeping the scoring in the upper 40s. A 30-20 or 30-21 result remains below the current total.

Final Picks: Southeastern Louisiana +13.5 and Under 52.5

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