Stanford vs Louisville Picks and Prediction for Saturday October 31, 2026
The Stanford Cardinal will be on the road Saturday afternoon for an ACC matchup against the Louisville Cardinals inside L&N Federal Credit Union Stadium in Louisville, Kentucky. The game is scheduled to begin at 3:15 PM ET, with coverage available on ACC Network. Stanford comes into Saturday 4-4 overall after picking up a 31-28 victory against NC State. Louisville is 4-3 on the year following a 34-26 victory over Syracuse in its last outing. Louisville comes into Saturday a huge -22.5 favorite and a -2100 on the money line. Stanford is a +1100, and the total is set at 60.5. Stay in the action with our College Football Picks.
Stanford looks for 3 in a row
Davis Warren is leading the Stanford offense this season with 1,933 yards and 11 touchdowns on 163 completions. Micah Ford is the top ball carrier on the team with 679 yards and eight touchdowns on 136 carries. Sedrick Irvin is second on the roster with 168 yards on 44 carries. Caden High leads the team with 440 yards and four touchdowns on 30 receptions.
The Stanford offense did just enough a week ago, scoring 31 points on 477 total yards. Defensively, Stanford gave up 28 points, including fourteen in the fourth quarter, on 381 yards. Davis Warren was phenomenal last week, completing 22 passes for 303 yards and four touchdowns. Micah Ford led the way on the ground with 150 yards on 22 carries. Caden High posted a team-high 103 yards and one touchdown on 9 receptions. Nico Brown chipped in four catches for 43 yards and two scores, and Sedrick Irvin added one catch for 17 yards and one touchdown.
Louisville tries to defend home field
Lincoln Kienholz is leading Louisville this season with 1,844 yards and 10 touchdowns on 121 completions, along with 251 yards and 10 scores on 71 carries. Isaac Brown is the top ball carrier on the team with 568 yards and four touchdowns on 83 carries. Keyjuan Brown has added 51 carries for 417 yards and five scores. Lawayne McCoy leads the team with 25 catches for 513 yards and four touchdowns.
The Louisville offense rolled a week ago, scoring 34 points, including 28 in the first half, on 425 total yards. Defensively, Louisville had their issues, giving up 26 points on 462 yards, but they forced 3 turnovers to seal the victory. Lincoln Kienholz led Louisville last week, completing 14 passes for 310 yards and one score, and ran the ball 10 times for 53 yards and two touchdowns. Keyjuan Brown added 50 yards and two touchdowns on 13 carries out of the Louisville backfield. Lawayne McCoy was the top target on the roster with five catches for 93 yards.
Stanford vs Louisville Picks and Prediction
Pick: Stanford +22.5
Louisville has the offensive advantage in this matchup, particularly with its ability to move the football both on the ground and through the air. The Cardinals have been productive offensively this season and should find plenty of opportunities against a Stanford defense that has consistently struggled to get opponents off the field. However, Louisville has also been vulnerable defensively, which gives Stanford a chance to remain competitive. The Cardinal showed improvement offensively against NC State, and their passing attack should find openings against a Louisville secondary that has surrendered significant yardage. Louisville should win comfortably, but Stanford will do enough down the stretch to cover.
Pick: Over 56.5
Neither defense has been particularly reliable, and both teams should find opportunities to put points on the scoreboard. Louisville has the more balanced offense and should be able to create explosive plays against Stanford's struggling defensive front. On the other side, Stanford quarterback Davis Warren is coming off a four-touchdown performance and should have chances to move the ball against a Louisville defense that has allowed opponents to sustain drives. If Stanford can contribute three touchdowns, Louisville's offensive production should be enough to carry this game over the total.