Stanford vs Notre Dame Picks and Prediction for Saturday October 10, 2026
The Stanford Cardinal will be on the road Saturday afternoon for a matchup against the Notre Dame Fighting Irish in South Bend, Indiana. Kickoff is scheduled for 3:30 PM with coverage on NBC and Peacock. Stanford will face one of its toughest opponents of the season as the Cardinal attempt to pick up a major road victory. Stanford will need a strong performance on both sides of the football to compete with a nationally ranked Notre Dame team. The Fighting Irish enter the weekend ranked No. 3 in the country and will look to continue their push toward the College Football Playoff. Notre Dame will have a significant home-field advantage and will attempt to take control of the game early. The Fighting Irish are favored by 38.5 points, with the total set at 54.5 points. Notre Dame is a massive money-line favorite, while Stanford is listed at +8000. Stay in the loop with our College Football Picks.
Stanford hunts the road win
Davis Warren leads the Stanford offense this season with 1,207 passing yards and five touchdowns on 102 completions, along with one interception. Micah Ford leads the Cardinal rushing attack with 302 yards and four touchdowns on 82 carries. Sedrick Irvin has added 145 yards on 35 carries, while Caleb Hampton has chipped in 27 yards on six carries. Caden High leads all Stanford receivers with 266 yards and three touchdowns on 17 catches. Benji Blackburn has added 159 yards on 20 receptions, while Zion Robinson has contributed 155 yards on seven catches.
Defensively, Stanford was obliterated a week ago, giving up 57 points as Wake Forest compiled 519 total yards. Offensively, Stanford was equally as bad, scoring just three points on 197 total yards. Davis Warren led the way for the Stanford offense last week, completing 19 passes for 136 yards. Micah Ford led the way on the ground with 45 yards on 16 carries. Nico Brown led all Stanford receivers with 42 yards on 4 receptions.
Notre Dame looks to defend its ranking
CJ Carr leads the Notre Dame offense this season with 1,197 passing yards and 13 touchdowns on 88 completions, along with 28 rushing yards and three scores on 12 carries. Aneyas Williams leads the Fighting Irish rushing attack with 266 yards and four touchdowns on 60 carries. Nolan James Jr. has added 262 yards and three touchdowns on 55 carries, while Jonaz Walton has chipped in 228 yards on 39 carries. Jordan Faison leads all Notre Dame receivers with 371 yards and four touchdowns on 25 catches. Malachi Gilbert has added 368 yards and two touchdowns on 18 receptions, while Jaden Greathouse has contributed 108 yards and one score on eight catches.
The Notre Dame offense scored 37 points on 475 total yards last week. Defensively, Notre Dame did the work as well, allowing 26 points on 286 yards after forcing 2 turnovers. CJ Carr led the way for the Notre Dame offense a week ago, completing 21 passes for 234 yards and four scores, and ran the ball four times for 15 yards and one touchdown. Jonaz Walton added a team-high 120 yards on 23 carries. Jordan Faison Chipped in a team-leading 132 yards and two touchdowns on 8 grabs.
Stanford vs Notre Dame Picks and Prediction
Pick: Notre Dame Fighting Irish -38.5 (-108)
Notre Dame should have a clear advantage Saturday afternoon when Stanford visits South Bend. The Fighting Irish have established themselves as one of the best teams in the country and will look to continue their strong season against an overmatched Stanford team. The Cardinal will need to find ways to protect the football and sustain drives to keep Notre Dame from controlling the game. The Fighting Irish should be able to establish their offense early and put pressure on Stanford throughout the afternoon. Notre Dame also has the defensive personnel to make things difficult for the Cardinal and force mistakes. The Fighting Irish have a significant talent advantage and should have little trouble picking up another victory at home.
Pick: Under 54.5 (-110)
Stanford could have a difficult afternoon offensively when the Cardinal take on a talented Notre Dame defense. The Fighting Irish should be able to limit Stanford's ability to move the football and create opportunities for their own offense. Notre Dame has enough firepower to put together several scoring drives, but the Fighting Irish may not need to keep pushing offensively if they build a comfortable lead. Stanford will need to find ways to avoid turnovers and prevent Notre Dame from getting short fields. The Cardinal may struggle to contribute much to the scoring, which could make it difficult for the combined total to climb. Look for Notre Dame to control the game while the final score stays below the number.