Troy vs. Clemson Picks and Prediction, Saturday, September 6, 2025
The #8 Clemson Tigers (0-1) dropped their home opener last weekend against LSU, but they’ll try to bounce back when they host the Troy Trojans (1-0) on Saturday. We’ve got you covered with our Troy vs. Clemson prediction. Kickoff is scheduled for 3:30 ET from Memorial Stadium in Clemson, SC. If you are struggling to pick winners, you've come to the right place. We have the strongest NCAAF Predictions.
Trojans Cruise in Week 1
Coach Gerad Parker is back for his second season with the Troy Trojans football program, and he’s looking to build on an underwhelming 4-8 (3-5 SB) mark from a season ago. He returns both coordinators, as Sean Reagan and Dontae Wright will run the offense and defense, respectively. Troy got its season started with a win last weekend, taking down Nicholls in a 38-20 affair. From the team level, the Trojans out-gained their opponent 416-249, while going an impressive 9-15 on third-down conversions. They won the turnover battle (0-1) as well.
In terms of personnel, Goose Crowder will lead the way under center this season. He logged 144 passing yards and three touchdowns in week one. Crowder also went for 43 yards and a score on the ground, but RB Tae Meadows led the way with 186 yards and a touchdown on 23 totes. Out wide, Crowder will be distributing the ball to WRs Roman Mothershed (32 yards, 1 TD) and Peyton Higgins (21 yards).
- Following week one, Troy is priced at +1600 to win the Sun Belt title.
- The Trojans finished last season ranked 76th in scoring (25.3 PPG), while coming in at 87th in yards per game (356.7).
- Defensively, they were 91st in points given up per game (29.9) and 47th in yards conceded per contest (369.1).
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#8 Tigers Lose as Home Favorites
Meanwhile, Coach Dabo Swinney and his Clemson Tigers didn’t get the season started on the right foot, as they lost outright at home as 4.5-point favorites to #9 LSU (17-10). The Tigers slid from fourth to eighth in the latest AP poll. Clemson’s defense was gashed for 356 total yards in the loss, and on the offensive side they went just 3-13 on third-down conversions. The expectations are high for the Tigers this year, as they’re the favorites to win the ACC title.
Mainly, that’s due to having a veteran quarterback in Cade Klubnik under center. The senior didn’t look overpowering in week one, posting a 50% completion rating (19-38) and adding 230 yards and an interception. Adam Randall led the rushing attack with only 16 yards, as the Tigers were limited to only 31 yards in the home loss. Out wide, WRs Bryant Wesco Jr. (66 yards) and T.J. Moore (55 yards) were Klubnik’s top targets.
- Clemson’s win total currently sits at 9.5 (-110/-110), and the program is priced at +150 to win the conference title.
- Touching on last year’s metrics, the Tigers were 19th in points per game (33.5) and 12th in yards per week (443.8).
- They were 47th in defensive scoring (24.2 PAPG) and 62nd in yards conceded per game (373.2).
Troy vs. Clemson pick
Spread Pick for Troy vs. Clemson
- Clemson Tigers -33.5 (-110) (5 units)
Clemson’s offense didn’t look very good last weekend, but it should be able to bounce back against a much inferior opponent in Troy. Personally, I’m not a huge Cade Klubnik truther, but he does tend to take care of business when facing lesser opposition. This will be a prime breakout spot for Klubnik and the Tigers, as they take on a Trojans side that ranked 91st in points allowed per game (29.9) last season.
On the flip side, I am expecting Clemon’s defense to hold up well on Saturday. They limited LSU to only 17 points and 108 rushing yards in week one. I’ll dive into more of the specifics below, but they should stonewall Troy’s offense and limit them to fewer than 10 points. I like Clemson to roll and win by 5+ touchdowns.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,502.00 |
| 2 |  Pro Sports Picks | +1,421.00 |
| 3 |  Brick Haus Sports | +634.00 |
| 4 |  David Delano | +492.00 |
| 5 |  Michael Briggs | +355.00 |
Over/Under Pick for Troy vs. Clemson
- Under 51.5 (-105) (5 units)
Troy is a run-heavy team. Last season, they were 49th in rushing play percentage, running the ball on 54.55% of their plays. That appears to have carried over to 2025, as their run-pass play splits were 44-24 in week one against Nicholls. Well, good luck establishing the run on Saturday against a Clemson defensive line that was ranked first in the country coming into the year (per PFF). Clemson games are 5-1 to the under when they’ve been favored the last six times. I like this game to land in the 42-3 range. I think we’re in for a blowout from this angry Clemson side.
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