Tulane vs. Ole Miss Prediction, Picks, Odds, and Line Movement for CFP December 20 2025
Tulane vs Mississippi picks headline this First Round College Football Playoff matchup, and I am breaking down the betting angles as part of my college football picks with Tulane facing Ole Miss in a rematch.
TLDR - Picks and Prediction
- Spread: Ole Miss -17.5
- Total: Under 56.5
- Projected Final Score: Ole Miss 31, Tulane 13
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Stats to Know for Tulane vs Ole Miss
- Ole Miss has won and covered each of the last four meetings against Tulane.
- The last two meetings between these teams have stayed under the total.
- Tulane has seen the under cash in each of its last four games.
- Tulane won its final five games by an average of 16.2 points per game.
Odds and Line Movement
Current Odds
| Team | Spread | Total |
|---|---|---|
| Tulane | +17.5 (-118) | Over 56.5 (-112) |
| Ole Miss | -17.5 (-104) | Under 56.5 (-108) |
Line Movement - Spread
| Date | Tulane | Mississippi |
|---|---|---|
| 12/15 | +17.5 (-118) | -17.5 (-104) |
| 12/10 | +17.5 (-110) | -17.5 (-110) |
| 12/08 | +16.5 (+100) | -16.5 (-122) |
Line Movement - Total
| Date | Over | Under |
|---|---|---|
| 12/16 | 56.5 (-112) | 56.5 (-108) |
| 12/15 | 55.5 (-114) | 55.5 (-106) |
| 12/09 | 56.5 (-114) | 56.5 (-106) |
Tulane vs Mississippi Game Preview and Analysis
This College Football Playoff matchup is a rematch that many would have preferred to avoid, as Ole Miss has completely controlled the recent history of this series. The Rebels have won and covered each of the last four meetings, including a dominant 45-10 win earlier this season in Oxford where they held a significant yards-per-play edge and forced Tulane to punt repeatedly.
Ole Miss was only forced to punt one time in that September meeting, while the defense held Tulane quarterback Jake Retzlaff to just 56 passing yards. The Rebels dictated both the pace and physicality of that game, and the matchup profile has not changed enough to suggest a drastically different outcome.
Tulane does enter this game on a strong run, having won its final five games by an average of 16.2 points per game. However, those games have leaned under the total, and the Green Wave’s passing offense has been a concern. Retzlaff threw only 14 touchdown passes this season and his rushing production declined noticeably down the stretch.
Coaching continuity is another major factor. Tulane head coach Jon Sumrall will remain with the team for this game, while former Ole Miss head coach Lane Kiffin has already departed. Defensive coordinator Pete Golding has taken over as head coach, and offensive coordinator Charlie Weis Jr. is also staying through the playoff run. With Golding in charge, I expect Ole Miss to maintain its defensive identity, which further supports an under-heavy game script.
Betting Trends (Tulane and Ole Miss)
- Ole Miss has won and covered four straight games against Tulane.
- The under has cashed in the last two head-to-head meetings.
- Tulane’s last four games have stayed under the total.
Key Injuries and Notes
- Ole Miss running back Kewan Lacy and quarterback Trinidad Chambliss have expressed uncertainty about their future plans.
- Both teams are navigating coaching transitions, with Ole Miss maintaining coordinator continuity.
Final Score Prediction
Mississippi 31, Tulane 13
ATS and Total Picks
- Spread: Mississippi -17.5
- Total: Under 56.5
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