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Tulane vs South Alabama Picks and Prediction for Saturday, September 6, 2025

By: Robert Antuann Updated 09/05/2025, 11:54 AM ET
Tulane Green Wave vs South Alabama Jaguars Picks and Prediction for Saturday, September 6, 2025

We have a battle of the undefeated programs taking place in nonconference action for Week 2 of the college football season as the Tulane Green Wave will be heading to Hancock Whitney Stadium on Saturday evening to take on the South Alabama Jaguars for our Green Wave vs. Jaguars prediction. With the game airing on ESPN+, this game is going to be exciting. The Green Wave (1-0) are coming off a 23-3 home win on Saturday against the Northwestern Wildcats while the Jaguars (1-0) are coming off a 38-21 home win over the Morgan State Bears on Saturday. Rivalries, tempo, trenches — NCAAF picks for Tulane Green Wave vs South Alabama Jaguars.

Wildcats Looking Sharp Early On

The Tulane Green Wave’s season has gotten off to a great level as they are coming off a 23-3 home victory over the Northwestern Wildcats in their most recent game. Quarterback Jake Retzlaff, completing 18-of-31 passes for 152 passing yards with one touchdown pass as well as 10 rushes for 113 yards (11.3 yards per attempt) and a rushing touchdown on the ground, has been a bright spot in the offense. The Green Wave was able to do a lot better running the football as the team ran 42 times for 269 yards (6.4 yards per carry) with a rushing touchdown in this game.

The Green Wave were able to do well to continue drives as they were able to go 6-for-15 on third down attempts. Defensively, Tulane dominated as they allowed three total points on 237 total yards. Tulane stepped up with five takeaways (four interceptions, one fumble recovery).

 

Injury Report for Tulane

  • Tight end Ty Thompson: Knee (Questionable)

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Jaguars Looking to Step Up

The South Alabama Jaguars were able to step up in their most recent game as they took down the Morgan State Bears 38-21. Quarterback Bishop Davenport had a great game as he completed 12-of-14 passes for 166 yards with a pair of touchdowns.

While the running game was able to get going, the passing game took over. Wide receiver Devin Voisin led the way for South Alabama as he recorded seven receptions for 69 yards (9.9 yards per catch) and a touchdown. He was a significant reason as to why the Jags were able to step up early.

South Alabama’s defense did a good job as they were able to hold Morgan State to 5-for-13 on third downs throughout the 60 minutes. They are in a good position to continue stepping up on this side of the field.

Injury Report for South Alabama

No injuries to report

Tulane vs. South Alabama Pick

Spread Pick for Tulane vs. USA

  •  Tulane Green Wave -10.5 (4 units)

The Tulane Green Wave are clearly the overall better team and should be able to continue stepping up. Jake Retzlaff looks comfortable with the program after just one game while South Alabama beat up on a cupcake in their schedule. Tulane has shown the ability to move the football well and creates a more balanced offense with their running mentality. All in all, go with the Tulane Green Wave to cover the spread.

 

Over/Under Pick for Tulane vs. South Alabama.

  • Under 50.5 (4 units)

These teams are going to run the football, which means the clock is consistently running as the Mean Green had 42 rushing attempts while the Jaguars recorded 41 rushes of their own. Both teams are going to be keeping the ball on the ground and that will reduce the number of total snaps for this game. Go with under 50.5 total points to hit as the better bet for this game here.

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