Utah Utes vs Wyoming Cowboys Picks and Prediction for Saturday, September 13, 2025
Get ready for an exhilarating Week 3 clash as the 20th-ranked Utah Utes battle it out with the Wyoming Cowboys in our Utes vs. Cowboys prediction. Set to unfold at War Memorial Coliseum on September 13th at 8:00 PM ET, this game, airing on CBSSN, promises an exciting matchup with two teams entering with a perfect 2-0 record. With these teams looking to step up in this matchup, let's dive into the stats, injuries, and key insights to preview what's in store. Find the edge fast with our NCAAF picks for Utah Utes vs Wyoming Cowboys.
Utes Looking to Roll
The 20th-ranked Utah Utes are getting ready to continue dominating on the offensive side of the ball as they are coming off a 63-9 home win over the Cal Poly Mustangs. Utah’s offense is led by quarterback Devon Dampier, who has been able to complete 38-of-48 passes for 398 yards with five passing touchdowns to begin the season. Their total offense stands at 505.0 yards per game (26th in NCAA), with rushing accounting for an amazing 279.5 yards (10th). The passing game has been middle of the pack compared to the rest of the country with an average of 225.5 yards per game (74th).
Defensively, Utah has excelled as they are allowing 221.5 total yards per game (19th), with their pass defense standing out as they are allowing a 50.0 completion percentage through the first two games. All signs are showing the Utah Utes are able to continue dominating at this level as the nonconference portion of their schedule continues.
Injury Report for Utah
- Safety Rabbit Evans: Undisclosed (Questionable)
- Defensive lineman Dallas Vakalahi: Undisclosed (Questionable)
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The Wyoming Cowboys are looking to get off to a hot start this season and they are coming off a 31-7 home win over the Northern Iowa Panthers. Quarterback Kaden Anderson has held his own this year as he completed 36-of-59 passes for 427 yards with three touchdown passes to one interception. As a team, they are ranked 73rd nationally in passing yards, averaging 225.0 per game. Wyoming’s total offense, which averages 402.5 yards per game, will need to find new ways to maintain its efficiency. The rushing game, contributing 177.5 yards per game (59th nationally), might see an increased emphasis on handing the ball off.
The Cowboys’ defense, allowing an average of 199.0 total yards per game, has been their strength this season. Their pass defense, in particular, has been impressive, conceding only 125.0 yards per game. Their rush defense, allowing 74.0 yards per game, remains a strong point and will be a critical force for the result of this game.
Injury Report for Wyoming
- Running back Nico Hamilton: Arm (Questionable)
- Running back Patrick Broadway II: Knee (OUT)
- Defensive lineman Dante Drake: Achilles (OUT)
- Defensive lineman Caleb Robinson: Achilles (OUT)
Utah Utes vs. Wyoming Cowboys Pick
Spread Pick for Utah Utes vs. Wyoming Cowboys
- Wyoming Cowboys +23.5 (4 units)
This is a lot of points to lay for this game, especially with a defense that is clicking on all cylinders like Wyoming has through its first two games. These teams have looked different, but this is easily the best defense that Utah has faced this season thus far. Kaden Anderson has looked sharp under center and just a few stops by the Wyoming defense makes things tough to reach the spread. Go with the Wyoming Cowboys getting more than three full touchdowns at home to cove the spread when facing a tough opponent.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,502.00 |
| 2 |  Pro Sports Picks | +1,421.00 |
| 3 |  Brick Haus Sports | +634.00 |
| 4 |  David Delano | +492.00 |
| 5 |  Michael Briggs | +355.00 |
Over/Under Pick for Utah Utes vs. Wyoming Cowboys
- Under 48.5 (4 units)
These offenses are looking sharp to begin the season, but this Wyoming Cowboys team has allowed just seven total points while the Utah Utes have given up 19 points through their first two games. Both teams are within the top 35 in yards per play allowed as the Utes are 31st with 4.1 yards per play allowed while the Cowboys are sitting in fifth place nationally only giving up 3.5 yards per play thus far. With two of the best defenses in the country, take under 48.5 total points to score here.
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