UTSA Roadrunners vs. Colorado State Rams Picks and Prediction for Saturday, September 20, 2025
The UTSA Roadrunners (1-2) were able to get their first win of the season as they are coming off a 48-20 home win over the Incarnate Word Cardinals on Saturday. Junior quarterback Owen McCown had a great game as he completed 30-of-36 passes for 243 yards with four passing touchdowns and a pair of rushing attempts for 10 yards (5.0 yards per carry).
The Colorado State Rams (1-1) are also playing well as they are coming off Sept. 6’s 21-17 home win over the Northern Colorado Bears. Junior quarterback Brayden Fowler-Nicolosi struggled in the game as he completed 13-of-25 passes for 132 yards with an interception while also running five times for 22 yards (4.4 yards per carry) with a rushing touchdown.
College gridiron clarity — NCAAF picks for UTSA Roadrunners at Colorado State Rams with key matchups.
Roadrunners Looking to Continue Passing Well
The UTSA Roadrunners are coming off a 48-20 win at home against the Incarnate Word Cardinals last week. UTSA was able to score 48 points on 442 total yards (243 passing, 199 rushing). The offense was able to move the football as they were 8-for-16 on third downs and recorded 25 first downs as a team. They were also able to run the ball at an incredible rate, averaging 6.8 yards per rushing attempt.
The defense stepped up as they gave up 20 points on 357 total yards (324 passing, 33 rushing) in the game. The defense was able to force four turnovers (two interceptions, two fumbles) in the game and really slowed down the Cardinals’ running game as they only averaged 1.2 yards per rush.
UTSA’s offense has stepped up as they are tied for 50th in college football with 36.0 points per game. Their defense is abysmal to begin the season on as their 35.0 points per game allowed ranks 121st in the nation.
Injury Report for UTSA
- Wide receiver David Amador II: Undisclosed (Questionable)
- Linebacker Camron Cooper: Undisclosed (Questionable)
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Rams Looking to Get Going
The Colorado State Rams are looking to continue building momentum from their last game as they won at home against the Northern Colorado Bears 21-17. The offense finished with 21 points on 371 total yards (141 passing, 230 rushing). The team was abysmal with keeping care of the football, committing five turnovers (four fumbles, one interception). However, the Rams were able to run the football at a solid rate as they averaged 5.0 yards per rushing attempt.
The defense looked sharp as they held Northern Colorado to 17 points on 223 total yards of offense (160 passing, 63 rushing). The team was able to get stops on the money downs as the Bears were limited to 3-for-14 on third down. The Rams did force a pair of turnovers (one fumble, one interception) as well.
The Colorado State Rams have been unable to score points consistently as they are tied for 107th in the nation with 21.0 points per game. Their defense has been struggling as they are giving up 27.5 points per game, which is 100th in college football.
Injury Report for Colorado State
- Wide receiver Kojo Antwi: Achilles (Questionable)
- Defensive lineman Gabe Jones: Undisclosed (OUT)
UTSA Roadrunners at Colorado State Rams Pick
Spread Pick for UTSA vs. Colorado State
- UTSA Roadrunners -4.5 (4 units)
The UTSA Roadrunners have looked like the better overall team as the stats indicate. Owen McCown has shown the ability to completely control things when he is on the field. When looking at Colorado State’s offense, there is a major concern is the ability to maintain possession as they have a -3 turnover ratio so far. The Rams are not doing too well and they need to step up, which won’t be this week. All in all, go with the UTSA Roadrunners to cover the spread here.
Over/Under Pick for UTSA vs. Colorado State
- OVER 59.5 (4 units)
These offenses have been able to move the ball down the field at a good level as the Roadrunners are averaging 6.0 yards per play while the Rams are averaging 4.8 yards per play throughout the season so far. The weather is going to be no precipitation, meaning McCown and Fowler-Nicolosi should be able to throw the football well. With the game being played in Colorado, the Roadrunners' defense specifically is going to be tired as the game continues on. Go with the over as the better bet.
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