West Virginia vs. Ohio Picks and Prediction, Saturday, September 6, 2025
On Saturday afternoon, Ohio (0-1) looks to get in the win column in their home opener, playing host to West Virginia (1-0). Ohio took a tough loss in its opener, while West Virginia opened their season with a blowout win. If you are looking for the full score info for this non-conference clash as well as other free NCAAF picks, then look no further than this in-depth West Virginia vs. Ohio prediction.
West Virginia comes into this game as a slight road favorite posted at -3.5 with a total of 60.5.
West Virginia Takes it to the Minnows
In their season opener, West Virginia had no problems in a 45-3 blowout win over FCS Robert Morris. The Mountaineers overcame a sluggish first half to score 35 points in the second half and for the game, they outgained the Colonials 625 yards to 123 yards. However, they were sloppy in the win with four turnovers. Nicco Marchiol was 17/20 for 224 yards with a TD and no INT, Jahiem White led four players with 50+ rushing yards with 93 yards, and Cam Vaughn had 127 receiving yards. WVU covered as a 40-point favorite and the total went Under.
- Rich Rodriguez is back as the head coach after 17 years away from Morgantown. He inherits a good team that went 6-7 last season and has a legit RB in Jaheim White, who has rushed for over 840 yards in his first two college seasons.
- Marchiol takes over under center after being the backup QB last season, and while facing an FCS team, he was impressive in the opener.
- The WR corps is solid and Vaughn may be a star in the making. Last season as a freshman at Jacksonville State, he had 803 receiving yards.
- The Mountaineers used the portal to help their defense and last season, ranking in the middle of the pack in run defense they only ranked 120th in the nation in pass defense and that is a concern.
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Ohio Can’t Come Through in the Clutch
In their opening game of the season, Ohio was on the road in a tough 34-31 loss to Rutgers, where they played great defense in the second half, only allowing three points, but were shut out in the fourth quarter. They outgained the Scarlet Knights 440 yards to 399 yards and had a balanced attack but took the loss. Parker Navarro was 21/31 for 239 yards with three TD and no INT and led the team rushing for 93 yards. Sieh Bangura chimed in for 86 rushing yards and Chase Hendricks had 115 receiving yards. The Bobcats easily covered as a 15.5-point underdog and the total went Over.
- Bryan Smith takes over an Ohio team that was 11-3 and won a bowl game.
- Navarro is back as the starting QB and last season passed for 2,423 yards with 13 TD and 11 INT and also rushed for over 1,000 yards.
- Bangura rushed for nearly 2,000 yards in two seasons and is back with Ohio after a non-productive season at Minnesota.
- The defense is the main question mark, as while the Bobcats’ D ranked 13th in the nation last season in scoring defense, but they lost many of their key players.
West Virginia vs. Ohio pick
Spread Pick for West Virginia vs. Ohio
- West Virginia -3.5 (+4 Units)
West Virginia had not problems in their opener in a blowout win, albeit against an FCS team. Ohio had a narrow loss where they put up 31 points but gave up 34 points and they were shut out in the fourth quarter. Each team has new head coaches but each also has some solid position players. Ohio is at home and narrowly beat a team from a major conference in this game, but can they turn that around in this one to get their first win of the season? Regarding the West Virginia vs. Ohio prediction, the Bobcats simply lost too many key players on the defensive side of the ball and while they will score points in this game, WVU will score more and the Mountaineers will win and cover.
Over/Under Pick for West Virginia vs. Ohio
- Over 60.5 (+4 Units)
The total is set pretty high in this game, but I am still leaning towards the Under. Ok, so West Virginia only gave up three points in their last game, but they were playing an FCS team. They struggled on defense last season and will give up a pretty high total facing an Ohio team that has weapons and scored 31 points in their first game. The Bobcats were solid on D last season but were gutted losing many key players and they gave up 34 points in their opener. West Virginia will take advantage of that and put up a high total and in what will be a less-than-defensive battle the total will go Over for this non-conference affair.
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