Wyoming Cowboys vs. Colorado Buffaloes Prediction and Picks - September 20, 2025
The Colorado Buffaloes will host the Wyoming Cowboys at Folsom Field on Saturday, with the kickoff slated for 10:15 PM Eastern. Both of these teams enter this contest coming off a loss. Read on for the Cowboys vs the Buffaloes prediction and more free NCAAF picks.
Wyoming Stonewalled At Home
Wyoming was unable to hang with Utah as they fell in a 31-6 final. The Cowboys were led by Kaden Anderson, who tossed for 108 yards on 12/23 passing and an interception. Samual Harris provided a few jolts of energy out of the backfield. Wyoming finished 3-12 on 3rd down for 229 total yards of offense and turned the ball over twice. The defense allowed 541 yards of offense, but came away with a turnover and a sack.
Wyoming enters the season riding defensive strength under head coach Jay Sawvel, while Kaden Anderson has taken over as the starting quarterback. Offensively, the Cowboys are averaging just 15.7 points per game, placing them in the bottom 100 in the country. They generate 327.7 total yards per game, ranking right inside the top 100. The passing game is performing better than expected—but Anderson is still completing fewer than 55% of his throws. On the plus side, the offensive line has done a solid job in protecting him. The ground attack is generating just under four yards per carry and nearly 150 ground yards per game. The inability to put points on the board stems from the offense turning it over 1.5 times per game, on average.
Wyoming Key Team Stats:
- Total Yards Per Game: 327.7
- 3rd-Down Conversion Rate: 38.10%
- Anderson TD/INT Ratio: 3:2
On defense, Wyoming has been stout, allowing just 15.5 points per game, ranking them at 27th in America. Opponents are generating roughly 385.0 yards per game, and they have been able to regularly move the sticks on 3rd down. The run defense has been paltry, with the Cowboys allowing over 5.5 per carry and over 200 yards per game. Through the air, the Cowboys are holding opposing QBs to a completion rate under 55% and their average completion depth of 4.7 yards is good for 10th in the country.
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Buffs Lose First Road Game
Colorado found themselves playing catch-up early on, and ultimately fell at Houston in a 20-36 final. The Buffaloes were led by Ryan Staub, who completed 19/35 passes for 204 yards and one touchdown with two interceptions. Simeon Price averaged over 10 yards per carry on five carries and scored a touchdown. Staub also fumbled twice, but Colorado was able to retain possession. The defense logged two sacks, but allowed the Cougars to put up over 430 yards of offense. Colorado finished 4-14 on 3rd down and put up 300 yards. Turnovers were the difference maker as Colorado finished -13.5 minutes in Time of Possession.
Colorado enters the week with Kaidon Salter named the starter at QB, bringing in experience from Liberty. Stalter has been battling Ryan Staub for the starting job. Offensive production has been mixed—Colorado is averaging 23.7 points per game, which ranks 76th nationally, while total offense is around generating 334.1 yards per game. The ground attack has allowed Colorado to try and stretch the ball downfield. On the ground, Colorado is generating over four yards per carry. However, the offense has struggled both on 3rd down and inside the red zone. On 3rd downs, the Buffaloes are moving the chains just over a third of the time. In the red zone, they sit right outside the top 50. Staub has shown he can stretch the field, and it remains to be seen how well Salter will do the same, though he comes from a high-octane offense at Liberty. QB protection has been a problem, and we saw Salter utilize his legs in week one. We should expect him to do so again here.
Colorado Key Team Stats:
- Total Yards Per Game: 334.1
- 3rd-Down Conversion Rate: 41.4%
- Salter TD/INT Ratio: 1:0
On defense, Colorado is allowing about 23.3 points per game, which lands them at 58th in the nation. The defense has been somewhat middling on third downs as they are allowing about 38.6% conversion, but it has been especially strong in the red zone, limiting opponents to scoring touchdowns on just 71.1% of their red zone trips, which is among the top 25 in the country. Getting into the backfield has been a strength, but Colorado is still allowing nearly five yards per carry and an average completion depth of over eight yards. They'll look to get right against a struggling Wyoming offense.
Wyoming vs. Colorado Pick
Spread Pick and Prediction for Wyoming vs Colorado
- Colorado -13.5 (4 Units)
While we saw the Wyoming offense perform well against Northern Iowa, turnovers continue to be a problem for this offense. As does any sort of ground-based threat. Colorado threw the ball 35 times against Houston and 36 times in their trouncing over Delaware, indicating they will throw the ball in any scenario. Salter can use his legs to extend drives, and even with the Cowboys' ability to march down the field, Colorado has one of the best red zone defenses in the country.
Colorado -13.5
Total Prediction for Wyoming vs Colorado
- Over 44.5 (4 Units)
We know Colorado will hang points on the board given the opportunity, and Wyoming may allow just that, as they allowed Utah to put up nearly 550 yards of offense. The Buffs have struggled in terms of giving up big plays downfield,d and Wyoming had three plays of 20 or more yards in their win over Northern Iowa. Look for both offenses to find a way to get down the field here and push this number over the total.
Over 44.5
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