L.A. Angels vs. Milwaukee Brewers Picks and Prediction, Tuesday, September 16, 2025
In the opener of an interleague series as the regular season draws to a close, the Milwaukee Brewers (91-59) play host to the L.A. Angels (69-81). The Brew Crew have qualified for the playoffs for the second straight season while the Angels have the longest playoff drought in the Majors not making the post-season since 2014. This L.A. Angels vs. Milwaukee Brewers prediction has the full score info, pitching matchup, and other free MLB picks.
The Brewers are a huge favorite in Game 1 posted at -255 with the Angels at +235 and a total of 7.5 runs.
Angels Get the Broom on the Road
In their last series, the Angels were on the road and were swept in a four-game set against the Seattle Mariners. In the series finale they were smoked losing 11-2 where they only had four hits and Oswald Peraza and Christian Moore each had a solo HR. The Halos are 4-6 in their last 10 games, are in the basement of the AL West, and have officially been eliminated from the playoffs.
- L.A. ranks 21st in the Majors in runs scored and only 28th in team ERA.
- Taylor Ward (.223 31 HR 98 RBI) leads the team in at bats and RBI and has two in the last five games.
- Mike Trout (.231 21 HR 58 RBI) has had a tough season and after ending a career-long drought in HR he only has one hit in the last three games.
- On the season, L.A. is 32-43 on the road.
Caden Dana (0-1 6.32 ERA 1.60 WHIP) gets the start in this series opener and in his last start was not sharp giving up five runs on five hits in 4 2/3 innings in a 12-3 loss to the Minnesota Twins. He has made two starts after his first two appearances were out of the bullpen and in them gave up seven runs in 9 2/3 innings.
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Lineup Quiets Down in Loss
After scoring a total of 17 runs in winning the first two games of their last series, the Brewers’ lineup quieted down in the last game in a 3-2 home loss to the St. Louis Cardinals. In the loss, Caleb Durbin and Danny Jansen each had a solo HR. Milwaukee is 5-5 in their last 10 games, has a five-game lead over the Chicago Cubs in the NL Central, and have the most wins in the Majors.
- On the season, the Brewers have had great balance, ranking tied for second in runs scored and second in team ERA.
- Christian Yelich (.264 28 HR 96 RBI) leads the team in HR and RBI and has a HR and three RBI over the last five games.
- Jackson Chourio (.280 20 HR 75 RBI) ranks second on the club in HR and RBI and has a HR and four RBI in the last four games.
- On the season, the Brewers are 48-27 at home.
Freddy Peralta (16-6 2.69 ERA 1.09 WHIP) takes the hill for Game 1 and was tagged for five runs in his last start, giving up six hits in five innings in a 6-3 loss to the Texas Rangers. The Brewers have lost three of their last four starts but in the five starts before the last one, he did not give up any runs in any of them.
L.A. Angels vs. Milwaukee Brewers Pick
L.A. Angels vs. Milwaukee Brewers
- Brewers - Run line -1.5 runs -125 (+4 Units)
The Brewers are gunning for the top seed in the playoffs while the Angels are out of the playoff race for the 11th straight season. Milwaukee had won two in a row before a loss in their last game and the Halos were swept in their last season, losing four games to the Mariners. Peralta was tagged up in his last outing, giving up five runs, but he did not give up any runs in the five starts before that. He is a Cy Young candidate, ranking tied for second in the Majors in wins and seventh in ERA and will get back to pitching well in this game. Dana will be making only his second start and in his last one, he gave up five runs. He and the Angels’ bullpen, which ranks 27th in bullpen ERA, will be hit hard by the Brewers' lineup. In terms of the L.A. Angels vs. Milwaukee Brewers prediction, the Brew Crew will be the much better team on the mound and at the dish and will take Game 1. The Brewers will also win by at least two runs, so take the run line to get better odds.
Over/Under Pick for L.A. Angels vs. Milwaukee Brewers
- Over 7.5 runs (+4 Units)
The total is set pretty low in this game at 7.5 runs and I am leaning towards the Over even though both teams only scored two runs in their last games. The Brewers had scored a total of 17 runs in their previous two games and they will score a lot of runs in this game, facing Dana, who gave up five runs in his last start, and the Halos’ bullpen, which ranks 27th in bullpen ERA. Peralta is Cy Young candidate but did not look like it in the last start, giving up five runs. However, he will bounce back and pitch well and in the five starts before the last one he did not give up any runs. The Angels will struggle to score, but that will not be the case for the Brewers, who will put up a high total, which is why the Over is the pick.
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