Arizona Diamondbacks vs. San Diego Padres Picks and Prediction for Saturday, September 27, 2025

The Arizona Diamondbacks (80-79, 77-72-10 O/U) will be taking on the San Diego Padres (94-65, 68-86-5 O/U) on Saturday night in the middle game of a pivotal three-game National League West series for our Diamondbacks vs. Padres prediction. This is being written ahead of the opening game of the series on Friday. Veteran left-hander Eduardo Rodriguez (9-8, 4.91 ERA) is going to be pitching in this game for the D-Backs while the Padres are sending righty Michael King (5-3, 3.57 ERA) to the hill. First pitch focus — MLB picks for Arizona Diamondbacks vs. San Diego Padres that cut through the noise.

Diamondbacks Looking to Capture Final NL Wild Card Spot

The Arizona Diamondbacks are looking to continue winning games and try to get the final NL Wild Card spot in as they are third in the NL West with an 80-79 record up to this point. The offense is on fire as they are fifth in baseball with a .251/.324/.433 team slash line while averaging 4.89 runs per game.

The Arizona Diamondbacks are coming off a brutal 8-0 home loss on Thursday against the Los Angeles Dodgers and the team only had one extra-base hits. Jalen Beeks recorded the loss as an opener, as he gave up a run in his one inning of work.

Second baseman Ketel Marte (27 HR, .892 OPS) has been one of the best at his position and is a reason why the team is still alive right now. Veteran southpaw Eduardo Rodriguez (9-8, 4.91 ERA) is going to be on the mound and is coming off a win over the Philadelphia Phillies, where he allowed zero runs on six hits with three walks and five strikeouts in six innings.

Injury Report for Arizona

• First baseman Tyler Locklear: Elbow (OUT)
• First baseman Pavin Smith: Quadriceps (OUT)
• Left fielder Lourdes Gurriel Jr: Knee (OUT)
• Pitcher Kevin Ginkel: Shoulder (OUT)
• Pitcher Tommy Henry: Elbow (OUT)
• Pitcher Christian Montes De Oca: Elbow (OUT)
• Pitcher Justin Martinez: Elbow (OUT)
• Pitcher Cristian Mena: Shoulder (OUT)
• Pitcher Corbin Burnes: Elbow (OUT)
• Pitcher AJ Puk: Elbow (OUT)
• Pitcher Blake Walston: Elbow (OUT)

Padres Looking to Heat Up

The San Diego Padres are looking to enter the playoffs strong as they are locked in the second NL Wild Card spot with an 87-72 record up to this point. The Padres are hitting at a respectable level as they are tied with the Minnesota Twins for 17th in the bigs with a .708 team OPS while averaging 4.24 runs per game.

The San Diego Padres are coming off Wednesday’s 3-1 home loss against the Milwaukee Brewers and Jackson Merrill homered in the game. Dylan Cease pitched well without factoring into the decision as he allowed a run over five innings.

Third baseman Manny Machado (26 HR, .786 OPS) has been quietly putting up a productive season and continues to flash the leather at the hot corner. Right-hander Michael King (5-3, 3.57 ERA) will be taking the mound and is coming off a victory over the Chicago White Sox, where he threw 5.0 shutout innings and gave up four hits with one hit by pitch, four walks, and four strikeouts.

Injury Report for San Diego

• Right fielder Ramon Laureano: Finger (Questionable)
• Pitcher Nestor Cortes: Elbow (OUT)
• Pitcher Jason Adam: Quad (OUT)
• Pitcher Jhony Brito: Forearm (OUT)
• Pitcher Joe Musgrove: Elbow (OUT)

Arizona Diamondbacks vs. San Diego Padres Pick

Spread Pick for Diamondbacks vs. Padres

• San Diego Padres ML (5 units)

The road/home splits for these starting pitchers shows a gap as Eduardo Rodriguez is 6-6 with a 4.74 ERA and a .294 batting average against in 76.0 innings (15 road starts) while Michael King is 3-2 with a 2.58 ERA and a 1.01 WHIP in 45.1 innings (nine home starts) thus far. These bullpens are on opposite sides of the stat page in giving up runs as San Diego leads MLB with a 3.05 bullpen ERA, while Arizona is 27th with an inflated 4.82 reliever ERA right now. The Padres are 3-1 in their last four games against the Diamondbacks, so take the San Diego Padres to win here.

Over/Under Pick for Diamondbacks vs. Padres

• Under (5 units)

Neither team is hitting too well with runners in scoring position this season as the D-Backs are tied with the Atlanta Braves for 13th with a .753 team OPS, while the Padres are 26th with a .696 team OPS in those chances. Neither team is putting up too many runs lately as Arizona is averaging four runs in their last six games, while San Diego is scoring 3.83 runs in that same stretch of action. The under is 3-1 in their last four games as well, so go with the under to hit in this penultimate game of the regular season.