Arizona Diamondbacks vs St. Louis Cardinals Picks and Prediction for Tuesday June 23 2026
Use Code SSWC The Arizona Diamondbacks and St. Louis Cardinals meet on Tuesday, June 23, 2026, at Busch Stadium in St. Louis, Missouri. First pitch is scheduled for 7:45 PM, and the game will be televised on MLB.TV. At the time of this writing the odds were not released. Arizona enters the matchup with a 39-38 record, while St. Louis comes in at 41-34. ESPN's Matchup Predictor gives the Cardinals a 54.0 percent chance to win compared to 46.0 percent for the Diamondbacks. Be sure to check out our free MLB picks.
Starting Pitchers Shape the Matchup
Arizona is expected to start Eduardo Rodriguez in this matchup. The left-hander enters with a 6-2 record, a 2.45 ERA, and a 1.23 WHIP across 88.1 innings. He has allowed 74 hits while recording 65 strikeouts, issuing 35 walks, and giving up nine home runs. St. Louis is expected to counter with Kyle Leahy. The right-hander owns a 5-4 record with a 4.63 ERA and a 1.57 WHIP over 70.0 innings. He has allowed 84 hits while striking out 59 batters, walking 26, and surrendering nine home runs.
Arizona Tries to Steady Things on the Road
The Diamondbacks enter Tuesday's contest with a 39-38 overall record and a 15-21 mark away from home. Arizona has gone 2-3 over its last five games. The Diamondbacks recently won over Minnesota and Los Angeles, but they also recently lost to Minnesota twice and Los Angeles once. Their most recent game was a 4-2 loss against Minnesota.
Arizona has posted a .238 batting average with 331 runs scored, 608 hits, and 68 home runs. The Diamondbacks own a .309 on-base percentage and a .384 slugging percentage. On the mound, Arizona carries a 4.30 ERA and a 1.30 WHIP while allowing opponents to hit .251. The pitching staff has recorded 536 strikeouts and issued 230 walks.
Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Subscribe Now
The biggest strength for Arizona in this matchup comes from the starting pitching edge. The Diamondbacks have a probable starter with a much lower ERA and WHIP than the St. Louis starter. That gives Arizona a clear path to compete, especially if the game stays tight early and the offense can provide enough support.
St. Louis Looks to Use Its Home Edge
The Cardinals enter this game with a 41-34 overall record and a 21-17 mark at home. St. Louis has gone 2-3 over its last five games. The Cardinals recently won over Kansas City and San Diego, but they also recently lost to Kansas City twice and San Diego once. Their most recent game was a high-scoring 12-10 victory over Kansas City.
St. Louis has produced a .249 batting average with 349 runs scored, 632 hits, and 87 home runs. The Cardinals own a .328 on-base percentage and a .402 slugging percentage. Their pitching staff has posted a 4.29 ERA and a 1.35 WHIP while allowing opponents to hit .256. St. Louis pitchers have accumulated 575 strikeouts and issued 248 walks.
The key strength for St. Louis is the offensive advantage. The Cardinals lead Arizona in batting average, runs scored, hits, home runs, on-base percentage, and slugging percentage. While the team pitching numbers are close, St. Louis has shown more overall offensive production, and that matters in a matchup where the predictor also leans toward the home side.
Arizona Diamondbacks vs St. Louis Cardinals Picks and Prediction
Arizona Diamondbacks vs St. Louis Cardinals Pick
- Pick: St. Louis Cardinals Moneyline
St. Louis enters with the better overall record, the better home record, and the edge in ESPN's Matchup Predictor. Arizona has the advantage in the starting pitching matchup based on ERA and WHIP, but the Cardinals hold broader offensive advantages across the team stats. With St. Louis leading in runs, hits, home runs, batting average, on-base percentage, and slugging percentage, I would side with the Cardinals at home.
Arizona Diamondbacks vs St. Louis Cardinals Total Pick
- Pick: Take the over if the total is set at 8.5
I would lean toward the over in this matchup. St. Louis has scored 349 runs and hit 87 home runs, while Arizona has scored 331 runs. The Cardinals also enter with a stronger offensive profile, and both teams have recently been involved in games with notable scoring. Even with Arizona having the stronger starting pitching numbers, the offensive data points toward enough run potential to look at the over.
Final Score Prediction: St. Louis Cardinals 5 – Arizona Diamondbacks 4
This prediction was written before the completion of game play on Monday.
Never Tried Picks and Parlays? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code BUCK
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
