Arizona Diamondbacks vs St. Louis Cardinals Picks and Prediction for Wednesday June 24 2026

The Arizona Diamondbacks and St. Louis Cardinals continue their series on Wednesday, June 24, 2026, at Busch Stadium in St. Louis, Missouri. First pitch is scheduled for 7:45 PM ET, with coverage available on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Starting Pitchers Featured at Busch Stadium

Arizona has not yet announced a starting pitcher for this matchup. St. Louis is expected to send Matthew Liberatore to the mound. Liberatore enters with a 3-4 record, a 5.23 ERA, and a 1.56 WHIP across 72.1 innings. He has allowed 86 hits, struck out 67 batters, walked 27, and surrendered 15 home runs.

Arizona Searching for a Turnaround

The Diamondbacks enter this contest with a 39-39 overall record and a 15-22 road record. Arizona has gone 2-3 over its last five games. The Diamondbacks recently defeated Minnesota and the Angels while suffering losses to St. Louis and Minnesota twice.

Arizona is batting .239 as a team with 333 runs scored, 617 hits, and 69 home runs. The Diamondbacks own a .309 on-base percentage and a .384 slugging percentage. Their pitching staff has posted a 4.29 ERA and a 1.30 WHIP while recording 540 strikeouts. Opponents are batting .251 against Arizona. The Diamondbacks are also 22-23 in night games.

The biggest challenge for Arizona has been offensive consistency. The Diamondbacks have scored fewer runs and hit fewer home runs than St. Louis. While their pitching staff owns a slightly higher ERA than the Cardinals, Arizona has done a better job limiting opposing hitters, as shown by its lower opponent batting average.

Cardinals Looking to Build Momentum

The Cardinals come into this game with a 42-34 overall record and a 22-17 home record. St. Louis has gone 2-3 over its last five games. The Cardinals recently defeated Arizona and Kansas City while suffering losses to Kansas City twice and San Diego.

St. Louis is hitting .249 as a team with 352 runs scored, 639 hits, and 87 home runs. The Cardinals have produced a .328 on-base percentage and a .400 slugging percentage. On the mound, they own a 4.26 ERA and a 1.34 WHIP while recording 577 strikeouts. Opponents are batting .256 against St. Louis. The Cardinals are 28-16 in night games.

The strength of St. Louis is its balanced offensive production. The Cardinals hold advantages in batting average, runs scored, hits, home runs, on-base percentage, and slugging percentage. Those offensive edges have helped them maintain a winning record and a strong mark in night games throughout the season.

Arizona Diamondbacks vs St. Louis Cardinals Picks and Prediction

Arizona Diamondbacks vs St. Louis Cardinals Pick

• Pick: St. Louis Cardinals Moneyline

The Cardinals enter this matchup with the better overall record, the stronger home record, and advantages across most offensive categories. St. Louis also owns a slight edge in the matchup predictor and already picked up a 3-2 victory over Arizona earlier in the series. With the Diamondbacks still listing their starter as undecided, the Cardinals are the preferred side.

Arizona Diamondbacks vs St. Louis Cardinals Total Pick

• Take the over if the total is set at 8.5.

I would lean toward the over if the number is set at 8.5. St. Louis has scored 352 runs and hit 87 home runs this season, while Arizona's pitching staff owns a 4.29 ERA. The Cardinals' projected starter also enters with a 5.23 ERA and has allowed 15 home runs. Those numbers suggest scoring opportunities for both teams.

Final Score Prediction: St. Louis Cardinals 6 – Arizona Diamondbacks 4

This prediction was written before the completion of game play on Tuesday.