Athletics vs Arizona Diamondbacks Picks and Prediction for Wednesday, July 22, 2026
The Athletics visit the Arizona Diamondbacks at Chase Field in Phoenix, Arizona, on Wednesday, July 22, 2026. The game is scheduled for 3:40 p.m. ET, with television coverage available on ESPN Unlimited and MLB.TV. The Athletics enter the matchup with a 43-57 record, while Arizona stands at 51-49. ESPN Analytics gives the Diamondbacks a 57.0% chance of winning and the Athletics a 43.0% probability. At the time of this writing the odds were not released. Before making any wagers on Wednesday’s matchup, be sure to check out our free MLB picks.
Starting Pitchers Meet at Chase Field
Gage Jump is scheduled to start for the Athletics and enters with a 3-5 record, a 3.78 ERA, and a 1.32 WHIP. The left-hander has worked 52.1 innings, allowing 52 hits, 17 walks, and four home runs while recording 56 strikeouts. Merrill Kelly gets the start for Arizona. The right-hander is 7-8 with a 5.20 ERA and a 1.49 WHIP across 98.2 innings. He has surrendered 107 hits, 40 walks, and 21 home runs while collecting 62 strikeouts.
Athletics Seek Another Productive Road Performance
The Athletics enter Wednesday with a 43-57 overall record and a 23-27 mark on the road. They are 2-3 over their last five games after recently winning over Arizona 5-2. The Athletics also recently defeated Washington 15-1 but lost the other two meetings against Washington by scores of 5-2 and 23-4. Their remaining loss was a 9-1 result against Chicago. The Athletics have experienced sharply contrasting offensive performances during this stretch, scoring at least five runs twice but being held to two runs or fewer in three contests.
The Athletics are batting .247 with 843 hits, 448 runs, and 124 home runs. They have produced a .324 on-base percentage and a .406 slugging percentage. Their pitching staff owns a 5.29 ERA and a 1.48 WHIP while issuing 389 walks and recording 854 strikeouts. Opposing hitters are batting .267 against the Athletics. The club has also gone 12-21 in day games.
The greatest advantage for the Athletics is their offensive production compared with Arizona. The visitors have the higher batting average, on-base percentage, and slugging percentage. They have accumulated 54 more hits, scored 13 more runs, and hit 30 more home runs than the Diamondbacks. The major concern is a pitching staff that carries the higher ERA, WHIP, walk total, and opposing batting average. However, the scheduled starter’s 3.78 ERA provides the Athletics with an opportunity to limit Arizona and build upon their recent 5-2 victory in this matchup.
Arizona Looks to Rebound Behind Its Home Record
Arizona enters this contest with a 51-49 overall record and a 29-22 record at Chase Field. The Diamondbacks have won three of their last five games despite recently losing to the Athletics 5-2. Arizona recently won over St. Louis twice, earning an 8-7 victory in 10 innings and a 5-3 win. The Diamondbacks also defeated Los Angeles 5-3, while their other loss against St. Louis came by a 5-4 score. Four of Arizona’s last five games have been decided by three runs or fewer.
The Diamondbacks are batting .237 with 789 hits, 435 runs, and 94 home runs. Arizona owns a .308 on-base percentage and a .387 slugging percentage. Its pitching staff has registered a 4.22 ERA and a 1.29 WHIP while issuing 289 walks and collecting 681 strikeouts. Opposing hitters have produced a .251 batting average against the Diamondbacks. Arizona is 20-18 in day games this season.
Arizona’s clearest strength is its overall pitching advantage. The Diamondbacks have a team ERA that is 1.07 runs lower than that of the Athletics, along with a WHIP that is lower by 0.19. Arizona has issued 100 fewer walks and holds opponents to a batting average that is 16 points lower. The concern comes with Wednesday’s starting matchup, where the Diamondbacks’ scheduled starter has the higher ERA and WHIP. Arizona will need its stronger overall pitching staff to help overcome that difference and a lineup that trails the Athletics in each of the supplied offensive categories.
Athletics vs Arizona Diamondbacks Picks and Prediction
Athletics vs Arizona Diamondbacks Pick
- Pick: Athletics Moneyline
I am backing the Athletics to win Wednesday’s game. Arizona has the better overall record, stronger home mark, and superior team pitching statistics, but the starting-pitcher comparison favors the visitors. The Athletics’ scheduled starter owns a 3.78 ERA and has allowed only four home runs in 52.1 innings, while Arizona’s scheduled starter carries a 5.20 ERA and has surrendered 21 home runs. The Athletics also hold advantages in batting average, runs, hits, home runs, on-base percentage, and slugging percentage. After winning the recent matchup 5-2, the Athletics offer the more appealing side despite Arizona’s 57.0% matchup probability.
Athletics vs Arizona Diamondbacks Total Pick
- Take the over if the total is set at 9.0.
I would play the over at 9.0. The Athletics have a 5.29 team ERA and a 1.48 WHIP, while Arizona’s scheduled starter enters with a 5.20 ERA and a 1.49 WHIP. The Athletics have hit 124 home runs and own a .406 slugging percentage, giving them an opportunity to generate another productive offensive performance. Arizona has scored at least five runs in three of its last five games, while the Athletics recently scored 15 runs in one victory and allowed 23 runs in one loss. Those numbers create enough scoring potential for this matchup to reach double digits.
Final Score Prediction: Athletics 6 – Arizona Diamondbacks 5
This prediction was written before the completion of game play on Tuesday.